Term
| Whole Blood (WB) preparation |
|
Definition
| hematocrit must be 40% and one unit contains 570 mL, made into components: red cells, platelets, plasma and cryoprecipitate, or can be irradiated to inhibit T cell proliferation. |
|
|
Term
|
Definition
| 21 (ACD) or 35 (CPD) days depending on anticoagulant |
|
|
Term
|
Definition
|
|
Term
|
Definition
| replace lost RBC and plasma volume, one unit raises Hct 3-5% or Hgb 1-1.5 g/dL, effects not seen until 48-72 hours post transfusion |
|
|
Term
| • Packed Red Blood Cells (pRBCs) preparation |
|
Definition
| centrifuged to remove plasma |
|
|
Term
|
Definition
| 21(ACD),35 (CPD) or 42 days depending on anticoagulant |
|
|
Term
| • pRBCs storage temperature |
|
Definition
|
|
Term
| • pRBCs indications for use |
|
Definition
| increase RBC mass in patient that require increased oxygen carrying capacity, one unit raises Hct 3-5% or Hgb 1-1.5 g/dL. |
|
|
Term
| • Platelets (PLTs) preparation: |
|
Definition
| continuous agitation, sometime irradiated |
|
|
Term
|
Definition
|
|
Term
| • PLTs storage temperature |
|
Definition
|
|
Term
| • PLTs indications for use |
|
Definition
| : patients with severe thrombocytopenia or abnormal platelet function |
|
|
Term
|
Definition
| F-VII prepared from pasteurization, solvent/detergent treatment and nanofiltration of plasma or recombinant DNA, F- IX prepared from pooled plasma using methods of separation and viral inactivation or recombinant DNA |
|
|
Term
|
Definition
|
|
Term
| • Factors storage temperaturat -18°C for 1 year (at -65°C for 7 years), when thawed 24 hours e |
|
Definition
| : <-30 °C, thawed at 37°C |
|
|
Term
| • Factors indications for use |
|
Definition
| F-VII for patients with hemophilia A, F-IX for patients with hemophilia B |
|
|
Term
| • Fresh Frozen Plasma (FFP) preparation |
|
Definition
| frozen within 6-8 hours after collection, thawed to room temperature and then held for 24 hours, |
|
|
Term
|
Definition
| at -18°C for 1 year (at -65°C for 7 years), when thawed 24 hours |
|
|
Term
| • FFP storage temperature |
|
Definition
| frozen within 8 hours of collection and stored at -18 °C , -65°C for 7 years, when thawed 1-6°C |
|
|
Term
| • FFP indications for use |
|
Definition
| treatment of liver failure, DIC, vitamin K deficiency, warfarin overdose or massive transfusion protocol |
|
|
Term
| • Cryoprecipitate (CRYO) preparations |
|
Definition
|
|
Term
|
Definition
| 12 months when frozen, 6 hours when thawed |
|
|
Term
| • CRYO storage temperature |
|
Definition
| frozen at -18°C and thawed at 20°C |
|
|
Term
| • CRYO indications for use |
|
Definition
| fibrinogen replacement (liver failure, DIC, massive transfusion, congenital fibrinogen deficiency) also as glue. |
|
|
Term
| • List which components can be prepared by apheresis |
|
Definition
| Components that can be prepared by apheresis are platelets, plasma, white cells, red cells and stem cells. |
|
|
Term
| • Evaluate clinical situations where apheresis can be used as a therapeutic tool. |
|
Definition
| The clinical situations where apheresis can be used therapeutically are in patients with Waldenstrom’s macroblobulinemia, Myasthenia gravis, Guillain-Barre syndrome, hyper viscosity syndrome, paraproteinemia, cryoglobulinemia, goodpasture’s syndrome, and myeloproliferative disorder with thrombocytosis, leukemia with leukocytosis and in stem cell harvesting. |
|
|
