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Final Cumulative-GU
NA
22
Pharmacology
Graduate
04/18/2015

Additional Pharmacology Flashcards

 


 

Cards

Term
ethinyl estradiol
Definition
estrogen in COC's--inhibit LH/FSH secretion (contraceptive) --thromboembolic disorders
Term
levonorgestrel
Definition
progestin in COC's--inhibit LH/FSH secretion (contraceptive) --thromboembolic disorders
Term
desogestrel
Definition
progestin in COC's--inhibit LH/FSH secretion (contraceptive) --thromboembolic disorders
Term
norethindrone
Definition
progestin in COC's--inhibit LH/FSH secretion (contraceptive) --thromboembolic disorders
Term
norethindrone (micronor; nor-Q.D)
Definition
oral progestin only tablets "minipills"--increased viscosity of cervical mucous, inhospitable uterus for implantation (women who want contraceptives but have contraindications for estrogen use or are lactating) --not as effective as COC's
Term
medroxyprogesterone acetate (depo-provera, depo-subQ provera 104)
Definition
IM or subQ injection of progestin every 3mo--inhibits ovulation (contraception) --contraindicated in patients w/ osteoporosis, subQ can be self administered but much more expensive
Term
conjugated equine estrogens (premarin)
Definition
Estrogen replacement therapy (vasomotor symptoms of menopause, vaginal atrophy/dryness) --thromboembolism
Term
conjugated equine estrogens + medroxyprogesterone acetate (prempro)
Definition
Hormone replacement therapy--estrogen+progesterone (vasomotor symptoms of menopause, vaginal atrophy/dryness) --thromboembolism
Term
raloxifene hydrochloride (evista)
Definition
estrogen agonist on bone receptors--inhibits proliferation of osteoclasts, increases transforming growth factor B3, decreases IL-6 (osteoporosis, breast cancer prophylaxis) --vasomotor SE's, thromboembolism
Term
clomiphene (clomid, serophene)
Definition
anti-estrogen--inhibits neg. feedback of estrogen on hypothalamus increasing FSH and LH (female infertility) --hot flashes, multiple pregnancies, ovarian cysts, blurred vision, ovarian cancer
Term
menotropins (pergonal)
Definition
LH and FSH isolated from postmenopausal women--induce ovulation in infertile women, stimulate spermatogenesis in males (hypogonadotropic hypogonadism) --ovarian enlargement, multiple gestations
Term
chorionic gonadotropin (pregnyl)
Definition
hCG from urine of pregnant women (prepubertal cryptochidism, spermatogenesis in hypogonadotropic hypogonadism, induce ovulation) --multiple gestations
Term
AndroGel
Definition
transdermal testosterone (hypogonadism, testosterone deficiency, male senescence/ANDRO-pause, athletic enhancement) --cardiovascular events
Term
androderm
Definition
transdermal testosterone (hypogonadism, testosterone deficiency, male senescence/ANDRO-pause, athletic enhancement) --cardiovascular events
Term
finasteride (proscar, propecia)
Definition
type II 5-alpha reductase inhibitor--decreases conversion of testosterone to dihydrotestosterone (BPH, male pattern baldness) --impotence
Term
dutasteride (avodart)
Definition
type I and II 5-alpha reductase inhibitor--decreases conversion of testosterone to dihydrotestosterone (BPH) --impotence
Term
oxytocin (pitocin, syntocinon)
Definition
--increases Calcium w/i endometrial smooth muscle, increases PGE (induction of labor contractions, reduce postpartum hemorrhage, abortion) --decrease BP, tachy, antidiuretic
Term
dinoprostone (prepidil, cervidil, prostin E2)
Definition
PGE2--increases secretion of collagenase, increase Ca in smooth muscle (stimulate uterine contractions, softening and dilation of cervix, abortion) --N/V
Term
ergonovine maleate (ergotrate)
Definition
ergot alkaloid--alpha agonist (postpartum/postabortion hemorrhage) --hypertension, N/V/D
Term
mifepristone-RU486 (mifeprex)
Definition
antiprogestin--detachment of the products of conception, sensitizes uterus to PGE (abortion) --used before misoprostol
Term
indomethacin (indocin)
Definition
prostaglandin synthetase inhibitor (delay labor) --premature closure of PDA, oligohydramnios
Term
nifedipine (procardia, adalat)
Definition
Ca channel blocker--decreases Ca influx into endometrial smooth muscle (delay labor)
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