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Synthesis & storage of vitamin A |
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Definition
β-carotene is ingested and absorbed in the intestine & converted to Vit. A in the mucosa. 90% is stored in the liver as retinal palmitate & carotenoids are stored in adipose. |
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Liver, milk, alfalfa & green leafy vegetables. |
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0.7mg (expressed in retinol equivalents: 1RE= 1mcg retinol = 6mcg β-carotene = 12mcg other carotenes) |
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+ Part of opsin in rod cells that function for photo reception + Synthesis of some glycoproteins in mucous + Controls cell growth in cell differentiation + Carotenoids are antioxidants |
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+ Night blindness + Xerophthalmia (dry eyes) + Skin disorders + Lack of growth |
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+ Occurs over 200mg in adults (from eating polar bear, seal liver or too many multivitamins) + Causes headache, nausea, vomiting, increased cerebrospinal fluid pressure, blurred vision |
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+ Calcium homeostasis: regulates calcium absorption (bone growth) + Cellular differentiation |
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+ Body can synthesise from 7-OH Cholesterol in skin if there's sufficient sunlight + Also found in oily fish, egg yolk, butter and liver |
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+ In kids: Rickets or osteomalacia (bowed bones) + In adults: Osteoporosis |
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+ Hypervitaminosis D + Toxic dose is only 10x higher than normal dose + Causes hypercalcaemia: Anorexia, nausea, vomiting, renal failure |
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+ Antioxidant (protects cells, lungs and DNA from damage) + Blood clotting: required as cofactor for clotting factors 2, 7, 9 and 10 + Bone formation |
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Food sources of vitamin E |
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+ Green leafy vegetables, plant oils, meat, eggs + Bacteria in large intestine |
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Very rare unless one has difficulty absorbing fats + Haemolytic anaemia/ generalised bleeding + spinocerebellar signs |
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+ Blood coagulation + Bone metabolism |
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