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EXSC 240- Chapter 10
Tissue Response to Injury
21
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Undergraduate 3
03/19/2017

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Term
3 phases of healing
Definition
-inflammatory response
-fibroblastic repair
-maturation and remodeling
Term
How long does the inflammatory response phase last?
Definition
2-4 days
Term
How long does the fibroblastic repair phase last?
Definition
From day 4 through week 6.
Term
How long does the maturation-remodeling phase last?
Definition
From about week 4 until 2-3 years+
Term
Signs of a new injury
Definition
-red
-swollen
-warm
-tender
-painful
-limited function
Term
What chemicals does the body release during inflammatory response?
Definition
-histamine
-leukotrienes
-cytokines
Term
What does the release of chemicals do?
Definition
-promotes vasodilation which increases blood flow and cell permeability (swelling)
Term
What is the vascular reaction upon injury?
Definition
-blood vessels constrict for 5-10 minutes, then dilate allowing increase in blood flow
-blood flow gradually slows down
Term
What does RICE stand for?
Definition
-Rest
-Ice packs
-Compress
-Elevate
Term
What are the signs of phase II?
Definition
-less swollen
-less painful
-possible bruising
-slowly regaining function
Term
What is the main purpose of fibroblastic repair phase?
Definition
-scar formation (fibroplasia) and tissue repair
Term
What is granulation tissue?
Definition
-contains fibroblasts, collagern, and capillaries laid out randomly
-fills gaps during healing
Term
Continued breakdown and synthesis of collagen=
Definition
increased strength
Term
Factors that impede healing
Definition
-extend of injury (micro/macrotears)
-muscle spasm- creates pulling o tissue
-atrophy
-infection
-age/health
-poor vascular supply
-edema/hemorrhage
Term
Cartilage healing is limited because?
Definition
-little or no direct blood supply
Term
During muscle healing, what forms in the injured area?
Definition
-myoblasts which lead to regeneration of myofibrils
-tissue aligns according to stress
Term
Why doesn't CNS heal as well as peripheral nerves?
Definition
-lacks connective tissue sheaths that produce Schwann cells
Term
Cutaneous
Definition
sharp, bright, burning, fast or slow onset
Term
deep somatic
Definition
stems from tendons, muscles, joints, periosteal, blood vessels
Term
visceral
Definition
originates from internal organs, diffused at first then may become localized
Term
psychogenic
Definition
individual feels pain but the cause is emotional rather than physical
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