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T 15-25x Increased Cardiac Output and Redistribution of Blood Flow |
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Transport O2 Transport nutrients Temp.. regulation |
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Heart - pups blood Arteries - carry oxygenated blood away from the heart to the tissues Arterioles - smaller arteries Capillaries - smallest vessels, where the actual exchange of gas an nutrients takes place |
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Pulmonary vein carries oxygenated blood to the heart from the lungs Pulmonary artery carries deoxygenated blood from the heart to the lungs |
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Right ventricle - Right atria via. the tricuspid valve - pulmonary artery through the pulmonary valve - lungs - pulmonary vein -left ventricle - left atria via bicuspid valve - aorta via aortic valve - arteires - arterolis - capilaries - venules - veins - vina cava - right atria |
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1. epicardium - lubricates outside of heart 2. myocardium - contraction 3. Endocardium - protects inside of heart |
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Ischemia -low blood flow Hypoxia - low O2 Ischemia leads to hypoxia |
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Blockage of Coronary Artery |
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Rater pressure product or Double product RPP = (HR x SBP)/100 |
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Slow twitch Oxidative Aerobic more mitochondria |
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More heat shock proteins Increased ability to remove free radicals |
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Differences: Shorter branched Fibers, involuntary contraction, intercalated disc (fuctional syncytium) Similarities: actin and myosin, require ca++, sliding filament, fiber length impacts force of contraction (Frank Starlings law of the heart) |
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Heart muscle cells connected via intercalated discs (leaky membrane) |
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systoli is the contraction phase, diastoli is the relaxation phase At rest diastoli is about twice as long as systoli During exercise diasolic phase shortens more than systoli |
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Pressure exerted against the walls of the arteries |
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normal = <120/80 HTN = Grater than or equal to 140/90 |
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90% primary 10% secondary (secondary to a disease) |
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PP = SBP-DBP MAP = DBP + 1/3(PP) |
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Map = Flow x TPR a. Pressure is a function of flow x resistance b.the amount of blood forced out of the heart per minute c. HR x SV d. Number of times the heart beats per minute e. Amount of blood forced out of the heart per beat f. HR = 72, SV 70ml, Q = 5l g. MAP increases, Q increases, TPR decreases h. TPR directly proportional MAP and Q, and indirectly related to vessel diamiter |
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ANS, baro receptors located in the corotid artery and the aortic arch, Long term regulation is via the kidneys which contorls blood volume |
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Intercalated discs Syncytium Fibrilation |
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SA AV Atrioventricular bundle Right and left bundle branches Purkinje fibers |
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HR Rest TR lower, max TR higher SV rest TR same, max TR higher Q rest TR same, max TR higher |
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SNS, PNS via vagus nerve SNS NT = NE PNS NT = ACH PNS is the brake causes hyperpolerization, SNS is the excellerator |
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withdrawl of PNS stimulation Increased SNS inervation |
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EDV(preload) ESV (afterload) contractility |
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EDV determined by venous return |
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Muscle pump increased Respiratory pump increased veins constrict increased |
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Circulation epinephrine and norepinephrine Increased sympathetic stimulation |
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liquid, proteins, hormones |
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Eurethrocyes transportation O2 Luckocytes immune response |
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The percent of blood composed of redblood cells males 42% females 38% |
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