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Exercise Physiology
Final exam
179
Physiology
Undergraduate 1
11/20/2013

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Term
homeotherms
Definition
Maintain constant body core temperature

Heat loss must match heat gain
Term
Normal core temperature
Definition
37°C
Term
Thermal gradient from body core to skin surface
Definition
Ideal gradient is ~4°C
Term
Voluntary Heat Production
Definition
Exercise
70–80% energy expenditure appears as heat
Term
Involuntary Heat Production
Definition
Shivering
-Increases heat production by ~5x
Action of hormones
Term
Heat Loss
Definition
Radiation
Conduction
Convection
Evaporation
Term
Radiation
Definition
Transfer of heat via infrared rays
60% heat loss at rest
Can be a method of heat gain
Term
Conduction
Definition
Heat loss due to contact with another surfac
Term
Convection
Definition
Heat transferred to air or water
Example: a fan pushing air past skin
Term
Evaporation
Definition
Heat from skin converts water (sweat) to water vapor
Requires vapor pressure gradient between skin and air

Most important means of heat loss during exercise
Term
Evaporation rate
Definition
Depends on:
Temperature and relative humidity
Convective currents around the body
Amount of skin surface exposed
Term
Heat required to raise body temp 1°C
Definition
= specific heat x body mass
Term
What percent of the body's energy expended during exercise is released as heat?
Definition
70% to 80%
Term
Body heat storage
Definition
difference between heat
production and heat loss

heat production - heat loss
Term
What is the Body’s Thermostat?
Definition
Hypothalamus
Term
Posterior Hypothalmus
Definition
promoting physiological changes that increase body heat
production (shivering) and reduce heat loss (cutaneous
vasoconstriction).
Term
Anterior Hypothalmus
Definition
initiates a series of physiological actions
aimed at increasing heat loss. These actions include the
commencement of sweating and an increase in skin blood
flow.
Term
Fever
Definition
ncreased body temperature above normal
–Due to pyrogens

Change in set point of hypothalamus
Term
Pyrogens
Definition
Proteins or toxins from bacteria

CAUSE FEVER
Term
During constant intensity exercise, the increase in body
temperature is directly related to ________?
Definition
to the exercise intensity.
Term
Body heat production increases in proportion to __________?
Definition
exercise
intensity
Term
Heat Index
Definition
Measure of body’s perception of how hot it feels
Relative humidity added to air temperature
Term
High relative humidity reduces __________?
Definition
evaporative heat loss
Term
Exercise in the Heat
Definition
Inability to lose heat

Higher sweat rate
Term
Dehydration of _________ can impair
performance?
Definition
1–2% body weight
Term
Sports drinks are _______ to water for rehydration
Definition
Superior
Term
Heat-related muscle fatigue
Definition
fatigue during prolonged and intermittent exercise
Term
Accelerated glycogen metabolism
Definition
Increased lactate accumulation
Term
Increased free radical production
Definition
Damage to muscle contractile proteins
Term
Heat Acclimation
Definition
Rapid adaptation (days to weeks) to environmental change
Term
Heat Acclimatization
Definition
Adaptation over a long time period (weeks to months)
Term
How long does it take to lose heat acclimation?
Definition
a few days if inactive
Term
Adaptions During Heat Acclimation
Definition
10–12% increased plasma volume

§  Earlier onset of sweating and higher sweat rate

Reduced sodium chloride loss in sweat

Reduced skin blood flow

Increased cellular heat shock proteins
Term
Exercise in a Cold Environment
Definition
Enhanced heat loss

hypothermia

Reduced dexterity in extremities (hands)–Due to reduced blood flow and slower nerve transmission
Term
Cold Acclimation
Definition
lower skin temperature at which shivering
begins
–Increased nonshivering thermogenesis

Maintain higher hand and foot temperature

Improved ability to sleep in the cold
Term
Recommendations for CARB calories
Definition
45–65% calories from carbohydrates
Term
Recommendations for PROTEIN calories
Definition
10–35% from protein
Term
Recommendations for FAT calories
Definition
20–35% calories from fat
Term
Adequate Intakes (AI)
Definition
Recommended daily intake based on apparently healthy people
Term
Tolerable Upper Intake Level (UL)
Definition
The highest intake level that is likely to pose no risk
Term
Estimated Average Requirement (EAR)
Definition
The intake estimated to meet requirements of half of healthy
people
Term
Estimated Energy Requirement (EER
Definition
–  Average dietary energy intake predicted to maintain energy
balance considering age, gender, weight, height, and level of
physical activity
Term
Water loss
Definition
Normally ~2500 ml per day

e can increase water loss to 6–7 liters per day with temp and exercise
Term
Water intake
Definition
2.7 L/day (women), 3.7 L/day (men)
Term
Fat-soluble vitamins
Definition
A, D, E, K
Term
Water-soluble vitamins
Definition
–  B vitamins
–  Vitamin C
Term
Calcium
Definition
–  Important in teeth and bone structure
-Osteoporosis
Term
Iron
Definition
Component of hemoglobin
Term
Sodium
Definition
– Associated with hypertension
Term
Carbohydrates
Definition
Sugars and starches
–  Major energy source
Term
Dietary fiber
Definition
Non-digestible carbohydrates and lignin
Term
Functional fiber
Definition
–  Non-digestible carbohydrates
Term
Glycemic index (GI)
Definition
ycemic index (GI)
–  Blood glucose response (over 2 hours) to carbohydrate food
–  Low GI foods make blood glucose regulation less challenging
Term
Glycemic load (GL)
Definition
–  Takes into account amount of food eaten
Term
Fats
Definition
Important energy source
§  Triglycerides
§  Phospholipids
§  Cholesterol
Term
Low-density lipoproteins (LDLs)
Definition
Low-density lipoproteins (LDLs)
§  Directly related to cardiovascular disease risk
§  Increased by diets high in saturated fat
Term
High-density lipoproteins (HDLs)
Definition
Protect against heart disease
Term
Clustering of risk factors associated with cardiovascular disease risk
Definition
Hyperinsulinemia, hyperlipidemia, hypertension, and obesity
Term
Proteins
Definition
§  Not a major source of energy
–  4 kcals•gram–1
§  High-quality proteins contain the nine essential amino
acids (body cannot produce on its own)
Term
Body mass index (BMI)
Definition
Weight (kg) / height (m2)
Term
Skinfold thickness
Definition
–  Estimate of total body fatness
Term
Air displacement plethysmography
Definition
–  Measurement of body density
–  Bod Pod system
Term
Severe obesity (fat mass >30 kg)
Definition
–  Due to increase in fat cell number (hyperplasia)
Term
Less severe obesity
Definition
Due to increase in fat cell size (hypertrophy)
Term
Hyperplasia
Definition
Associated with greater difficulty losing weight and maintaining
weight loss
Term
Dynamic energy balance
Definition
–  Increase in energy intake results in increased body weight
Term
Basal metabolic rate (BMR)
Definition
Rate of energy expenditure under standardized conditions

Represents 60–75% total energy expenditure
Term
What happens to BMR during fasting?
Definition
–  Reduced in response to reduced caloric intake (dieting or
fasting)
Term
Thermogenesis
Definition
“Heat generation”
Term
Brown adipose tissue
Definition
§  Increases heat production in response to norepinephrine and thyroid
hormones
Term
Weight loss in conjunction with exercise
Definition
–  Less lean body mass is lost
–  More fat mass is los
Term
What do carbohydrates increase in endurance athletes?
Definition
–  Increases muscle glycogen and performance time
Term
Carbohydrate Intake Prior to or During a Performance
Definition
Improves performance by maintaining blood glucose

Does not spare muscle glycogen utilization

§  Allows maintenance of power output and lower RPE
Term
Carbohydrate intake prior to exercise may cause:
Definition
–  Fall in blood glucose during exercise
§  Not dependent on amount of CHO consumed
Term
Carbohydrate Intake Post-Performance
Definition
–  Increased permeability to glucose
–  Increased glycogen synthase activity
–  Increased muscle sensitivity to insulin
Term
Formerly sedentary individuals Appetite Effects with Exercise
Definition
loss of appetite when on an exercise program
Term
Weight loss in conjunction with exercise
Definition
less lean mass is lost

more fat mass is lost
Term
exercise and weight loss
Definition
Exercise contributes a small fraction to weight loss
Term
Exercise to maintain weight and prevent weight gain
Definition
150–250 min per week of moderate-intensity exercise
Term
Exercise to achieve and sustain weight loss
Definition
250+ min per week of moderate-intensity exercise
Term
Fluid replacement during exercise associated with:
Definition
–  Lower HR
–  Lower body temperature
–  Lower RPE
Term
Hyponatremia
Definition
Dangerously low Na+ concentration
Term
Iron Deficiency
Definition
affects VO2 max and endurance
Term
Why are vitamins important?
Definition
Important for energy production
Term
Overload
Definition
–  Training effect occurs when a system is exercised at a level
beyond which it is normally accustomed
Term
4 areas of exercise specificity
Definition
-Muscle fibers involved
§  Energy system involved (aerobic vs. anaerobic)
§  Velocity of contraction
§  Type of contraction (eccentric, concentric, isometric)
Term
Reversibility
Definition
Gains are lost when overload is removed
Term
Training to increase VO2 max
Definition
–  Large muscle groups, dynamic activity
–  20–60 min, 3–5 times/week, 50–85% VO2 max
Term
Genetic predisposition of VO2 max
Definition
-Accounts for about 50% of VO2 max
-Prerequisite for very high VO2 max
Term
Calculation of VO2 max
Definition
VO2 max = HR max x SV max x (a-vO2) max

Product of maximal cardiac output and arteriovenous difference
Term
Differences in VO2 max in different populations
Differences in VO2 max in different populations due to....
Definition
due to differences in Stroke Volume max
Term
Training-induced increase in maximal stroke volume is due to
Definition
both an increase in preload and a decrease in afterload.
Term
Increased preload is primarily due to _______
Definition
an increase in end diastolic ventricular volume and the associated
increase in plasma volume
Term
What happens when stroke volume is increase?
Definition
↑ Preload (EDV)
↓ Afterload (TPR)
↑ Contractility
Term
How quickly does training changes in Stroke Volume occur
Definition
Rapidly

within 6 days of training
Term
The HERITAGE Family Study
Definition
Designed to study the role of genotype in cardiovascular, metabolic, and hormonal responses to exercise and training
Term
↑ Muscle blood flow causes.....
Definition
↓ SNS vasoconstriction

-Improved ability of the muscle to extract oxygen from
the blood

–  ↑ Capillary density
–  ↑ Mitochondrial number
Term
decreased afterload is due to ________
Definition
a decrease in the
arteriolar constriction in the trained muscles, increasing
maximal muscle blood flow with no change in the mean arterial blood pressure.
Term
Endurance Training-Induced Changes in
Fiber Type and Capillarity
Definition
Fast-to-slow shift in muscle fiber type

Increased number of capillaries
Term
What are the benefits of an increased number of capillaries
Definition
–  Enhanced diffusion of oxygen
–  Increased removal of wastes
Term
the Increases of
Mitochondrial Content in Skeletal
Muscle Fibers with endurance training effects:
Definition
Mitochondria in the muscle

Mitochondrial content increases quickly

Results in increased endurance performance
Term
The effects of the amount Mitochondria and Performance
Definition
–  Lower [ADP] needed to increase ATP production and VO2

Oxygen deficit is lower following training with more mitochondira

–  Less lactate and H+ formation
–  Less PC depletion
Term
Mitochondrial oxidation of FFA
Definition
Increased enzymes of β-oxidation
-burns more fat
Term
Endurance Training effects on fat
Definition
Increased utilization of fat and sparing of plasma glucose and muscle glycogen

Transport of FFA into the muscle

Transport of FFA from the cytoplasm to the mitochondria
Term
Endurance training improves the ability of muscle fibers to ________
Definition
maintain homeostasis during prolonged exercise.
Term
Free radicals
Definition
produced by contracting muscles
–Can damage muscle contractile protein
Term
endogenous antioxidants
Definition
Protects against oxidative damage and fatigue

Endurance training increases these
Term
What can increase the
buffering capacity of the exercised muscles?
Definition
High intensity (interval) exercise training c
Term
What effect can endurance training have on muscle buffering capacity?
Definition
disruption of the blood pH during submaximal work
because endurance trained muscles produce less lactate
and H+
Term
Primary signals for muscle adaptation
Definition
- MECHANICAL STRETCH!!! #1
–  Calcium
–  Free radicals
–  Phosphate/muscle energy levels
Term
What do primary signals increase to adapt to stress?
Definition
Protein Synthesis increased
Term
what causes the training-induced
adaptation that occurs in muscle fibers
Definition
an increase in the amount of specific proteins.
Term
What do the primary signals do after activating?
Definition
activate secondary signaling pathways
Term
What are some of the responses after an exercised induced signaling event?
Definition
–  Fast-to-slow fiber type shift
–  Mitochondrial biogenesis
–  Antioxidant enzyme synthesis
Term
Peripheral feedback from working muscles
Definition
Group III and group IV nerve fibers

§  Responsive to tension, temperature, and chemical changes
§  Feed into cardiovascular control center
Term
What structures are the Central control of cardiorespiratory responses
Definition
Motor cortex, cerebellum, basal ganglia
Term
What does the central control of cardiorespiratory center do
Definition
Recruits muscle fibers

Stimulates cardiorespiratory control
Term
What does the reduction in “feedback” from chemoreceptors in the
trained muscle and a decreased need to recruit motor units cause
Definition
Reduced...

Sympathetic
HR
Ventilation
Term
What causes a decrease in VO2 max from not training?
Definition
Decrease in maximal stroke volume

decrease in oxygen extraction

decrease in mitochondria #'s in muscle
Term
How long does it take to get retrained in endurance training?
Definition
3–4 weeks of retraining

Muscle mitochondria double
Term
Muscular strength
Definition
Maximum force a muscle or group of muscles can generate
Term
Muscular Endurance
Definition
Ability to make repeated muscle contractions against a lighter than maximum weight
Term
Strength training for gains in strength
Definition
High resistance (2-10 reps max)
Term
Strength training for gains in endurance
Definition
Low resistance (20+ reps per set)
Term
what causes a decline in strength after age 50
Definition
Loss of muscle mass (sarcopenia)

Loss and reorganization of motor units
Term
Progressive resistance training
Definition
Causes muscle hypertrophy and strength gains
Term
What are the beginning changes in resistance training?
Definition
Neural adaptations
-responsible for early gains in strength
-increased ability to recruit motor neurons
Term
Hyperplasia
Definition
Increase in muscle fiber number
-Only 5-10% responsible for muscle enlargement
Term
Hypertrophy
Definition
Enlargement of both type I and II fibers

Increased cross-sectional area of fibers
Term
What muscle changes occur in hypertrophy
Definition
–  Increase in myofibrillar proteins
–  Increases number of cross-bridges
–  Increased ability to generate force
Term
What effect does resistance training how on toxins in the body?
Definition
improves antioxidant capacity by 100%
Term
What fiber type changes does resistance training create?
Definition
fast-to-slow shift in muscle fiber types
Term
Primary Signal in resistance training
Definition
Increased muscle stretch
Term
What do secondary signals from resistance training do?
Definition
Promote protein synthesis (by up to 50-100%)
Term
What responses does the body produce from resistance training signaling?
Definition
Muscle Hypertrophy
Increased # of myonuclei in each fiber
Term
what do satellite cells in muscles provide after resistance training?
Definition
Provide a source of additional nuclei in muscle fibers, which are required to achive maximal fiber hypertrophy
Term
Detraining effects on Strength and Muscle Size
Definition
- Slow decrease in strength
-small changes in fiber size
Term
Retraining and reduced training effects on Strength and Muscle Size
Definition
Within 6 weeks after resuming training

Can maintain strength with reduced training for up to 12 weeks
Term
resistance training stoppage compared to the rate of detraining following endurance exercise
Definition
rate of detraining from resistance exercise is slower
Term
Endurance vs. strength training
Definition
-Endurance training increases mitochondrial protein

–  Strength training increases contractile protein

-combining strength and
endurance training impairs strength gains


-Both depend on intensity, volume, and frequency of training
Term
What factors explain why strength training coupled with endurance training is not effective?
Definition
neural
factors, low muscle glycogen content, overtraining, and
depressed protein synthesis.
Term
Physical activity
Definition
–Any form of muscular activity
–Can reduce the risk of death from all causes
–Primary risk factor for coronary heart disease
Term
Physical fitness
Definition
Set of attributes that relate to ability to perform physical activity
Term
Exercise
Definition
A subset of physical activity that is planned, with a goal of
improving or maintain fitness
Term
Acute response to Exercise
Definition
Occur with one or several exercise bouts but do not improve
further
Term
Rapid responses
Definition
Benefits occur early and plateau
Term
Linear
Definition
Gains are made continuously over time
Term
Delayed
Definition
Occur only after weeks of training
Term
What is the Risk of cardiac arrest in vigorously active men?
Definition
–  Higher during exercise
–  Lower overall (exercise + rest) risk
Term
Screening
Definition
Risk of cardiovascular complications is related to degree of pre-existing cardiac disease
Term
Guidelines for exercise progression
Definition
Start with moderate-intensity activity, then increase duration and/or intensity
Term
Exercise prescription for Cardiac Risk Factors
Definition
Dynamic, large muscle activities
Term
ACSM recommendations for exercise
Definition
3–5 sessions per week

20–60 min per session

200–300 Cals per session
Term
2 ways to determine THR (Target Heart Rate)
Definition
Direct Method- From maximal GXT

Indirect Method- Heart rate reserve (Karvonen) method (take 70-85% of max HR)
Term
VO2 Reserve
Definition
Difference between VO2 max and resting VO2

Most useful at low fitness levels
Term
Benefits of Resistance Training
Definition
Improves glucose metabolism

Reduces risk of falls
Term
What Environmental conditions can elevate exercise heart
rate?
Definition
Heat and Humidity (more blood circulation to skin)

Altitude (Lower O2 to hemoglobin)
Term
Overload Training Principles
Definition
Increased capacity of a system in response to training above the
level to which it is accustomed
Term
Specificity Training Principles
Definition
–  Specific muscles involved
–  Specific energy systems that are utilized
Term
Reversibility Training Principles
Definition
When training is stopped, the training effect is quickly lost
Term
Who has greater training improvement?
Definition
individuals with lower initial fitness
Term
Benefits of warming up before exercise
Definition
Increases cardiac output and blood flow to skeletal
–  Increases muscle temperature and enzyme activity
–  Opportunity for stretching exercises
Term
Benefits of Cooling-down after exercise
Definition
Return blood “pooled” in muscles to central circulation
Term
Three methods of training to improve Aerobic Power
Definition
–  Interval training
–  Long, slow distance
–  High-intensity, continuous exercise
Term
Long, Slow Distance training
Definition
Based on the idea that training improvements are
based on volume of training
Term
High-Intensity, Continuous Exercise training
Definition
Appears to be the best method of increasing VO2 max
and lactate threshold
Term
Injuries with Training
Definition
result of overtraining

Strength and flexibility imbalance
Term
Training Energy systems to Improve Anaerobic Power
Definition
ATP-PC system

Glycolytic system
Term
ATP-PC system
Definition
Short (5–10 seconds), high-intensity work intervals
Term
Glycolytic system
Definition
Short (20–60 seconds), high-intensity work intervals
Term
Isokinetic Strength-Training
Definition
Exertion of force at constant speed
Term
Increased muscle mass adaptations
Definition
–  Hypertrophy
–  Hyperplasia
Term
Hypertrophy
Definition
Increased muscle fiber diameter
Term
Hyperplasia
Definition
Increased number of muscle fibers
Term
Progressive Resistance Exercise (Progressive Overload)
Definition
–  Periodically increasing resistance (weight lifted) to continue to
overload the muscle
Term
Linear periodization Strength Training
Definition
Shift from high volume/low intensity to low volume/high intensity
training

greater strength gains
Term
Delayed onset muscle soreness (DOMS)
Definition
Appears 24–48 hours after strenuous exercise

Due to microscopic tears in muscle fibers or connective tissue
Term
Steps Leading to DOMS
Definition
Strenuous muscle contraction results in muscle damage

Calcium leaks out of SR and collects in mitochondria

Results in inflammatory process

Edema and histamines stimulate pain receptors
Term
The Repeated Bout Effect
Definition
A bout of unfamiliar exercise results in DOMS
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