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- a branch of biological science concerned with the function of organisms and their parts |
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- a branch of physiology that deals with the functioning of the body in response to exercise (acute and chronic adaptations). These responses to exercise are dependent on the intensity, duration, frequency and type of exercise and the environmental circumstances, diet and physiological status of the individual |
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received the Nobel Prize for work related to muscle or muscular exercise A.V. Hill |
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Heat production during muscle contraction and recovery |
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Relationship of O2 consumption and lactic acid in muscle |
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Function of the capillary circulation |
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Harvard Fatigue Laboratory |
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D.B. Dill Directed the lab from 1927–1947 Conducted research in numerous areas Exercise, clinical, and environmental physiology - Basis of much of what we know today Made careful and precise measurements Using “new” instruments and techniques |
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Active Research Areas in the Harvard Fatigue Laboratory Metabolism |
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Maximal oxygen uptake Oxygen debt Carbohydrate and fat metabolism during long-term work |
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Active Research Areas in the Harvard Fatigue Laboratory Environmental physiology |
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Altitude Dry and moist heat Cold |
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Active Research Areas in the Harvard Fatigue Laboratory Clinical physiology |
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Gout Schizophrenia Diabetes |
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Active Research Areas in the Harvard Fatigue Laboratory Aging |
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Basal metabolic rate Maximal oxygen uptake Maximal heart |
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Active Research Areas in the Harvard Fatigue Laboratory Blood |
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Acid-base balance O2 saturation: role of PO2, PCO2, and carbon monoxide Nutrition Nutritional assessment techniques Vitamins Foods |
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Active Research Areas in the Harvard Fatigue Laboratory Physical fitness |
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On x-axis (horizontal) Manipulated by researcher ex. percentage |
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On y-axis (vertical) Changes as a function of independent variable ex. heart rate, oxygen consumption,Blood pressure, hormone |
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Maintenance of a constant and “normal” internal environment |
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Physiological variable is unchanging, but not necessarily “normal” Balance between demands placed on body and the body’s response to those demands Ex exercise for 3 minute under normal environment the heart rate reaches it. the max heart rate is 200 |
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Control Systems of the Body
Intracellular control systems |
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Protein breakdown and synthesis Energy production Maintenance of stored nutrients |
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Control Systems of the Body
Organ systems |
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Pulmonary and circulatory systems Replenish oxygen and remove carbon dioxide |
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Biological Control System |
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Series of interconnected components that maintain a physical or chemical parameter at a near normal (constant ) value |
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Biological Control System Components Sensor or receptor |
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Detects changes in variable detects the chemical changing, our vessels contain lots of receptor. also send message to the control center. |
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Biological Control System Components Control center |
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Assesses input and initiates response |
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Biological Control System Components Effector: |
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Changes internal environment back to normal |
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Response reverses the initial disturbance in homeostasis |
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Increase in extracellular CO2 triggers a receptor Sends information to respiratory control center Respiratory muscles are activated to increase breathing CO2 concentration returns to normal Most control systems work via |
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Example of Homeostatic Control:Regulation of Blood Pressure Stimulus |
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Example of Homeostatic Control:Regulation of Blood Pressure Receptors |
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Baroreceptors in carotid arteries and aorta |
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Example of Homeostatic Control:Regulation of Blood Pressure Integrating center |
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Example of Homeostatic Control:Regulation of Blood Pressure Effector |
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Example of Homeostatic Control:Regulation of Blood Pressure Response |
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Decreased blood pumped from heart |
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can be seen in the respiratory systems regulation of the co2 concentration in the extracellular fluids. It also serve to restore normal value of a variable to maintain homeostasis. |
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Example of Homeostatic Control:Regulation of Blood Pressure |
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(1) heart action causes increasing blood pressure in blood vessels (2) the baroreceptors in carotid artery relay information to brain that blood pressure has increased (3) brain signals heart to contract more slowly and with less force. (4) blood pressure decreases |
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Example of Homeostatic Control:Regulation of Blood Glucose Illustration of the regulation of blood glucose concentration
negative feedback |
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Eating, increase blood glucose, pancreas, insulin,cellular uptake of glucose, blood glucose. before meal we have high level of insulin not high level of glucose. after meal high level of glucose activation pancreas to release insulin which bind to insulin receptor than glucose take to the cell migrate to liver and muscle glycogen. |
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figure 2.7 blood glucose concentration |
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the rise in blood glucose signals the pancrease to release insulin, which then lowers blood glucose by increase cellular uptake. failure of the blood glucose control result in (diabetes.) |
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Failure of a Biological Control System Results in Disease |
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Failure of any component of a control system results in a disturbance of homeostasis Example: Type 1 diabetes Damage to beta cells in pancreas Insulin is no longer released into blood Hyperglycemia results This represents failure of “effector |
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Example of Homeostatic Control: Cellular Stress Response figure 2.8 |
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the process starts with a stressor that promotes protein damage. stresses associated with exercise that are known to produce protein damage which include high temperature. reduced cellular oxygen, low PH, and the production of free radicals. damaged proteins become signals for the cell to produce stress protein. after synthesis these stress protein work to repair damaged protein and restore homeostasis. |
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oxytocin release by the hypothalamus when the head of the baby moves into the birth canal, the increase pressure on the cervix stimulates sensory receptor. the excited sensor then send a neural message to the brain which reponds by trggering the release of the hormone oxytocin from the pituitr gland. the oxytocin then travels via the blood to the uterus and promotes increased contractions. the cervix becomes more stimulated and uterine contractions become stronger until birth occurs the oxytocin release stops and shuts off. |
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Test of Homeostatic Control Submaximal exercise in a cool environment |
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- The body’s control systems can maintain steady state |
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Test of Homeostatic Control Intense exercise or prolonged exercise in a hot/humid environment |
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May not be able to maintain steady state Severe disturbances in homeostasis can occur |
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