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191
Biochemistry
Undergraduate 3
04/30/2014

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Term
Which one of the following is a subclass of structural isomers?
Definition
Functional group isomers
Term
A graduate student worked for his doctorate project and managed to isolate 64 different steroisomers of a very important biochemical compound. How many chiral centers will his compound have?
Definition
6
Term
How many chiral centers are in the molecule of glucose (Fisher projection)?
Definition
4
Term
An important class of geometrical isomers are?
Definition
Cis-Trans isomers
Term
The optical activity of enantionmers can be measured by?
Definition
specific rotation
Term
A racemic mixture will have the following percentage of the L stereoisomer
Definition
50%
Term
Ribose a very importatn monosacchardie in RNA is a:
Definition
Aldopentose
Term
How many molecules of glucose could be found in an oligosaccharide?
Definition
6
Term
Glucose and galactose have a similar chemical structure but they differ in the orientation of the hydroxyl group at
Definition
C4
Term
How many hydroxyl groups are in the molecule of galactose (Fisher projection)
Definition
5
Term
How many ketone groups are in the molecule of galactose (Fisher projection)
Definition
0
Term
A good source of fructose is
Definition
honey
Term
A glycosidic bond is formed from the reaction between
Definition
two hydroxyl groups
Term
The glycosidic bond in sucrose is
Definition
Alpha-Beta-1,2
Term
What type of glycosidic bond cannot be hydrolyzed in lactose intolerant individuals?
Definition
Beta-1,4
Term
Sugars in our diet are converted by enzymes in our body to
Definition
glucose
Term
Which one of the following carbohydrates is branched?
Definition
glycogen
Term
ALpha and beta glucose differ in the orientation of the hydroxyl group linked to
Definition
C1
Term
How many chiral centers are in the Haworth projection of glucose?
Definition
5
Term
How many oxygen atoms do you expect to find in a typical tetrose?
Definition
4
Term
How many hydrogen atoms do you expect to find in a typical hexase
Definition
12
Term
What carbohydrate units form the molecule of glycogen?
Definition
glucose
Term
What glycosidic bond is located at the branching point in amylopectin?
Definition
Alpha-1,6
Term
Which one of the following carbohydrates usually has a structural role in plants?
Definition
Cellulose
Term
The only difference between ribose and deoxyribose can be found at
Definition
C2
Term
The Benedict Test for monosaccharides is based on the following property
Definition
monosaccharides are reducing sugars
Term
How many molecules of glucose do you expect to find between to adjacent branches in the molecule of glycogen?
Definition
Around 10
Term
What sugar do you expect to be accumulated in the body of a patient suffering from galactosemia?
Definition
Galactose
Term
What pollysaccharide adopts a linear helical-three-dimensional configuration?
Definition
Amylose
Term
Which one of the following is an example of a complex liquid?
Definition
Lipoproteins
Term
Sucrose hydrolysis will generate
Definition
glucose and fructose
Term
Which one of the following C18 fatty acids has the highest melting point?
Definition
C18 Saturated
Term
What chemical group is always present in the molecule of a fatty acid?
Definition
Carboxyl
Term
What reaction can increase the melting point of a fatty acid?
Definition
hydrogenation
Term
Eicosanoids are derivatives of the following fatty acid
Definition
arachidonic acid
Term
Which one of the following is NOT obtained from the hydrolysis of a phophoglyceride?
Definition
sphingosine
Term
How many hydroxyl groups are in the molecule of glycerol?
Definition
3
Term
The main reactants of teh saponification reaction are
Definition
a base and fatty acid ester
Term
How many molecules of fatty acid can be obtained from the hydrolysis of a molecule of lecithin?
Definition
2
Term
Which one of the following CANNOT be classified as a subclass of Eiconsanoids?
Definition
Steriods
Term
Which one of the following is NOT part of the structure of a galactocerebroside?
Definition
Glycerol
Term
The pharmacological effect of aspirin is caused by its ability to inhibit the synthesis of
Definition
prostaglandins
Term
How many molecules of carbohydrate are in a typical cerebroside?
Definition
1
Term
Which one of the following is an example of phosphoglyceride?
Definition
Cephalin
Term
Which one of the following vitamins is not considered a Lipid?
Definition
C
Term
Fats and oils belong to the follwoing class of lipids?
Definition
triglycerides
Term
What lipids form the nerve cell membranes?
Definition
Sphingomyelins
Term
Which ones of teh following are nonglyceride lipids?
Definition
glycosphingolipids
Term
The difference between fats and oils is determined by
Definition
the type of fatty acids in the structure
Term
How many fatty acids are in the structure of a monoglyceride?
Definition
1
Term
How many free hydroxyl groups are in the structure of a monoglyceride?
Definition
2
Term
Whihch one of the following is a neutral lipid?
Definition
tryglyceride
Term
Cyclooxygenase is an important enzyme involved in the synthesis of the following lipids?
Definition
tromboxanes and prostaglandins
Term
The acid hydrolysis of a fatty acid ester will generate
Definition
A fatty acid and an alcohol
Term
Which one of the following lipids does not have a phosphate group in the structure?
Definition
cerebroside
Term
How many carbon atoms are in the molecule of arachidonic acid?
Definition
20
Term
How many molecules of glycerol are necessary for the synthesis of a molecule of lecithin?
Definition
1
Term
What biological process is NOT regulated by eicosanoids?
Definition
Linoleic acid synthesis
Term
What saturated fatty acid has the highest melting point?
Definition
C24
Term
Which one of the following CANNOT be part of the hydrophillic head of a phosphoglyceride?
Definition
Sphinogsine
Term
The chemical structure of testosterone is based on the follwoing structural unit
Definition
isoprene
Term
How many hydrocarbon rings can be found in the cholesterol molecule?
Definition
4
Term
Which one of the following is NOT a cellular function for cholesterol?
Definition
precursor of insulin
Term
What class of hormones regulate carbohydrate metabolism in the body?
Definition
glucocorticosteriods
Term
What steriod has an anti-inflammation effect?
Definition
Cortisol
Term
A wax is formed in the reaction between the following chemical groups
Definition
hydroxyl and carboxyl
Term
What are the products obtained from the hydrolysis of a wax molecule?
Definition
a fatty acid and an alcohol
Term
What type of lipid is most likely to be found on the surface of lipoprotein particles?
Definition
Phospholipid
Term
Which one of the following is a critical part of cellular membranes?
Definition
cholesterol
Term
Cholesterol is transported from liver to cells as part of
Definition
LDL
Term
Which one of the following is a steriod?
Definition
bile salt
Term
A pharmaceutical company discovered a new cholesterol-lowering drug. When testing this drug on patients, what class of lipoproteins do you expect to be significantly decreased in pateints that tested this drug?
Definition
LDL
Term
The lipid bilayer of cellular membranes is based on?
Definition
phosphoglycerides
Term
The fluidity of teh cell membranes is based on the following component in its structure
Definition
unsaturated fatty acids
Term
What classes of lipoproteins have the lowest protein content?
Definition
chylomicrons and VLDL
Term
What class of lipoproteins transports cholesterol from tissues to the liver?
Definition
HDL
Term
Which one of the following is NOT a component of cellular membranes?
Definition
chylomicrons
Term
What cellular mechanism is used for cholesterol delivery to the cells?
Definition
endocystosis
Term
VLDL is synthesized in the
Definition
Liver
Term
Bile salts are synthesized from
Definition
cholesterol
Term
Proteins are polymers of
Definition
amino acids
Term
Which one of the following does not have a chiral center?
Definition
glycine
Term
Which one of the following is a basic amino acid?
Definition
lysine
Term
Which one of the following has a hydroxyl (OH) group?
Definition
threonine
Term
What amino acid has an aromatic ring in its side chain?
Definition
phenylalanine
Term
Which one of the following is NOT part of the side chain in polar amino acids?
Definition
carboxyl group
Term
A biochemistry student was able to isolate an amino acid from a human protein. Studying the amino acid, he determined that it belongs to the polar neutral amino acids class. However, he was not able to identify any hydroxyl or amide groups on the side chain. What amino acid was located?
Definition
Cysteine
Term
Amino acids are classified based on
Definition
polarity of the side chain
Term
How many polypetide chains can be found in the typical quaternary structure of collagen?
Definition
3
Term
Which ones are not proteins?
Definition
waxes
Term
How many iron ions can be found in the quaternary structure of hemoglobin?
Definition
4
Term
What type of chemical interaction stabilizes protein secondary structures?
Definition
hydrogen bonds
Term
The overall charge of a zwitterion at the isoelectric point is
Definition
0
Term
Please consider the following peptide: Lys-Arg-Gly-Arg-Gly-Asp-Glu-Glu. How many peptide bonds are in this peptide?
Definition
7
Term
Please consider the following peptide: Lys-Arg-Gly-Arg-Gly-Asp-Glu-Glu. What is the amino terminus amino acid in this peptide?
Definition
Lysine
Term
Please consider teh following peptide: Lys-Arg-Gly-Arg-Gly-Asp-Glu-Glu. What is the carboxy terminus amino acid in the peptide?
Definition
Glutamic acid
Term
Please consider the following peptide: Lys-Arg-Gly-Arg-Gly-Asp-Glu-Glu. If the peptide is hydrolyzed into two equal haves, which one will have acidic properties?
Definition
The C-terminus half
Term
Please consider the following peptide: Lys-Arg-Gly-Arg-Gly-Asp-Glu-Glu. How many disulfide bonds can this peptide form?
Definition
0
Term
Please consider the following peptide: Lys-Arg-Gly-Arg-Gly-Asp-Glu-Glu. How many nonpolar amino acids will generate the complete hydrolysis of this polypeptide?
Definition
2
Term
What level of protein structure is altered during protein hydrolysis?
Definition
primary structure
Term
Which one is NOT true about enzymes?
Definition
They can only work in the presence of coenzymes
Term
Which one of the following enzymes is a transferase?
Definition
kinase
Term
Mutases belong to the following class of enzymes
Definition
Isomerases
Term
What reaction is catalyzed by the enzyme phosphatase?
Definition
Hydrolysis
Term
A newly discovered enzyme is able to catalyze teh addition of a phosphate group to any peptide made of eight amino acids. This is a typical example of a
Definition
apoenzyme
Term
THe oxidized form of the coenzyme nicotinamide adenine dinucleotide is
Definition
NAD+
Term
Which one of the following could be a cofactor for an enzyme
Definition
a vitamin
Term
The reduced form of the coenzyme flavin adenine dinucleotide is
Definition
FADH2
Term
Which one of teh following is a cofactor but NOT a coenzyme?
Definition
Cu2+
Term
What is the reason for the inactivity of most enzymes at pH 2?
Definition
enzyme denaturation
Term
THe conversion of galactose into glucose in the small intestine is catalyzed by a
Definition
isomerase
Term
Triglyceride digestion in the small intestine is catalyzed by a
Definition
hydrolase
Term
A researcher was able to identify the three dimensional conformation of an enzyme using X RAy crystallography. He was surprised to see that the shape of the enzyme is different when the substrate is bound. This is a clear proof that
Definition
the induced fit model is valid
Term
During the formation of the transition state
Definition
the enzyme might put stress on a bond, bring thee substrates into close proximity, might modify the pH of the microenvironment
Term
The following enzyme belongs to the class of isomerases
Definition
phosphoglycerate mutase
Term
What enzymes do not belong to the class of hydrolases
Definition
ligases
Term
It is most likely that urease has
Definition
absolute specificity
Term
The most important part of any enzyme is
Definition
the catalytic active site
Term
The optimal pH of the enzyme pepsin is
Definition
acidic
Term
An aldohexose is in the L conformation if
Definition
the hydroxyl group linked to C5 is on the left side
Term
How many chiral centers are in the structure of a typical triose?
Definition
1
Term
Which one of the following is NOT true when talking about enantiomers?
Definition
They are determined by the rigidity of the C=C double bond
Term
An example of a geometrical isomer is
Definition
cis trans isomers
Term
What chemical group is always present in the structure of monsaccharides?
Definition
hydroxyl
Term
How many carbon atoms are found in a molecule of deoxyribose
Definition
5
Term
What is the maximum number of enantiomers a biomolecule with 4 chiral centers could have have?
Definition
16
Term
Which one of the following monosaccharides is a pentose?
Definition
ribose
Term
Which one of the following monosaccharides is a ketose?
Definition
fructose
Term
D-Ribose, a sugar found in nucelic acids, rotates polarized left in a counterclockwise direction. It is considered to be
Definition
levorotatory
Term
A chemist can obtain glucose from fructose using the following chemical reaction in the lab
Definition
isomerization
Term
Lactose intolerant individuals have genetic mutations affecting the enzyme repsonsible for the digestion of the following glycosidic bond
Definition
Betea-1,4
Term
What glyosidic bond is found in both amylopectin and amylose?
Definition
Alpha-1,4
Term
An enzyme that is able to hydrolyze the following bond is necessary for cellulose digestion
Definition
Beta-1,4
Term
Which one of the following is a non-reducing sugar?
Definition
Sucrose
Term
Which one of the following is NOT a polysaccharide?
Definition
Lactose
Term
What glycosidic bond is found in glycogen but not amylose?
Definition
Alpha-1,6
Term
Which one of the following is NOT a characteristic of saturated fatty acids?
Definition
They are liquid at room temperature
Term
Which one is true for an unsaturated fatty acid?
Definition
It is most likely to contain cis double bonds
Term
Which one of the following is a class of nonglyceride lipids
Definition
Steroids
Term
Which one of the following is a class of nonglyceride lipids
Definition
Steroids
Term
Which one of the following is a class of nonglyceride lipids
Definition
Steroids
Term
Which one of the following is a class of nonglyceride lipids
Definition
Steroids
Term
Which one of the following is not part of cellular membranes?
Definition
cortisol
Term
Cholesterol is delivered to the cells through the process of
Definition
endocytosis
Term
WHich of the following is NOT a steroid?
Definition
Cholin
Term
LDL is synthesized in the
Definition
liver
Term
The only amino acid with a free thiol (SH) group is
Definition
cysteine
Term
Which one of the following amino acids is NOT non-polar
Definition
Lysine
Term
Which one of the following is a basic amino acid?
Definition
Histidine
Term
Which one of the following is NOT a polar amino acid?
Definition
Methionine
Term
Which one of the following amino acids has a free hydroxyl group?
Definition
serine
Term
Which one of the following amino acids has more than one carboxyl group?
Definition
aspartic acid
Term
What type of chemical interaction stablizes the protein primary structure?
Definition
peptide bond
Term
THe most common type of protein secondary structure is
Definition
alpha helix
Term
What pair of amino acids could form a salt bridge in the tertiary structure of a protein?
Definition
Lysine-Aspartic acid
Term
Which one of the following proteins has quaternary structure?
Definition
collagen
Term
What protein has the strongest affinity (attraction) for oxygen?
Definition
myoglobin
Term
A peptide bond is formed in the reaction between the following chemical groups
Definition
carboxyl and amino
Term
In glycoproteins, the carbohydrate part is a
Definition
prosthetic group
Term
how many heme groups can be found in the molecule of myogolbin
Definition
one
Term
Which one of the following is an essential amino acid?
Definition
lysine
Term
What level of protein structure is not altered during protein denaturation?
Definition
primary structure
Term
A newly discovered fatty acid dehydrogenase is capable to convert any saturated fatty acid in an unsaturated fatty acid. WHat type of specificity does this enzyme have?
Definition
linkage
Term
What enzymes do NOT belong to the class of hydrolases?
Definition
Reductases
Term
A newly discovered enzyme is able to catalyze the removal of a methyl group from any nucleotide in the structure of DNA. We can consider this enzyme to have
Definition
group specificity
Term
Which one is NOT true about the enzyme catalytic active site?
Definition
it binds the substrate with strong covalent bonds
Term
Which one is NOT true about enzymes
Definition
They incresase the energy of activation for metabolic reactions
Term
Epimerases belong to the following class of enzymes
Definition
isomerases
Term
What reaction is catalyzed by the enzyme lipase
Definition
hydrolysis
Term
Which one of the following is not a class of enzyme specificity
Definition
transient
Term
The enzyme lactate dehydrogenase is a good example of
Definition
oxidoreductase
Term
What is the typical characteristic of the induced fit model of enzyme activity
Definition
flexibility of the catalytic active site
Term
The nucleoid is characteristic for
Definition
prokaryotic cells
Term
The covalent bond that links the nucleotides in the DNA structure is
Definition
phosphodiester bond
Term
The sugar component of DNA is
Definition
deoxyribose
Term
Which one of the following is an important component of DNA
Definition
cytosine
Term
Which one of the following is a purine nitrogen base?
Definition
Guanine
Term
FOr the DNA sequence GTGACACA how many hydrogen bonds are formed when paired with the complementary sequence?
Definition
20
Term
For the DNA sequence 5'-GAATTCACTA-3' which one of the following is the complementary strand?
Definition
5'-TAGTGAATTC-3'
Term
Which one of the following sequences could be part of the pepsin gene?
Definition
AAATGCTA
Term
The "backbone" of the DNA primary structure is formed from
Definition
sugars and phosphate groups
Term
Please consider the following sequence of mRNA: 5'-C-C-C-A-A-A-G-A-U-G-C-G-A-C-U-C-C-G-G-G-C-C-U-A-G-C-C-A-3' What are the start and stop codons on this sequence?
Definition
AUG, UAG
Term
Please consider the following sequence of mRNA: 5'-C-C-C-A-A-A-G-A-U-G-C-G-A-C-U-C-C-G-G-G-C-C-U-A-G-C-C-A-3'How many amino acids will have the polypeptide synthesized based on this mRNA?
Definition
5
Term
Please consider the following sequence of mRNA: 5'-C-C-C-A-A-A-G-A-U-G-C-G-A-C-U-C-C-G-G-G-C-C-U-A-G-C-C-A-3' When this mRNA will be translated, the first codon that will occupy the P site on the ribosme will be
Definition
AUG
Term
Please consider the following sequence of mRNA: 5'-C-C-C-A-A-A-G-A-U-G-C-G-A-C-U-C-C-G-G-G-C-C-U-A-G-C-C-A-3' When this mRNA will be translated, the first codon that will occupy the A site on the ribosome will be
Definition
CGA
Term
Please consider the following sequence of mRNA: 5'-C-C-C-A-A-A-G-A-U-G-C-G-A-C-U-C-C-G-G-G-C-C-U-A-G-C-C-A-3' The first amino acid in the polypeptide synthesized based on the above mRNA sequence will be
Definition
methionine
Term
Please consider the following sequence of mRNA: 5'-C-C-C-A-A-A-G-A-U-G-C-G-A-C-U-C-C-G-G-G-C-C-U-A-G-C-C-A-3' The tRNA that will bring the fourth amino to the ribosome will have the following anticodon
Definition
5'-CCG-3'
Term
The main enzyme involved in the transcription is
Definition
RNA polymersae
Term
Which one of the following is NOT a STOP codon
Definition
AUG
Term
Intrachain A=U hydrogen bonding are only characteristic of
Definition
tRNA
Term
The termination of protein translation involves the presence of
Definition
release factors
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