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Exam II
Genetic Model, Heritability, Inbreeding, EBV, and Selection
43
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Undergraduate 3
11/03/2016

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Term
What is the genetic model?
Definition
P=G+E
Term
Define each of the variables P=G+E
Definition
P-phenotype
G-genotype/genetic value
E-environment
Term
What are the categories when discussing environment and how are they different?
Definition
Macro-environment: affects entire group
Micro-environment: affects individuals
Term
What are the two different types of environmental effects?
Definition
Permanent: affects individual remainder of life
Temporary: affects individual single production cycle
Term
What is a contemporary group?
Definition
a group of animals w/an EQUAL OPPORTUNITY to perform. (minimal environmental differences; same season, building, feed)
Term
What are the factors that are considered when determining contemporary groups and why?
Definition
Number of sires: compare for selection; can select from among the best families and individuals for traits.
Sires in multiple groups: increases accuracy from more data on each sire family.
Number of offspring per sire: matter of accuracy
Born w/in short period and tested together: minimizes environmental effects
Term
What are the optimal number of sires to compare at a time and the ideal number of offspring records for each?
Definition
3-4 sires
Approx. 40 offspring.

Both due to MC=MR
Term
If all animals w/in a contemporary group can be tested, how should animals be selected for testing?
Definition
At random to eliminate bias
Term
Why do we use records adjustment factors?
Definition
To compare animals on an equal basis
Expand the contemporary group
Term
What do we adjust records for and what are some examples?
Definition
Known and predictable sources of information
-Age
-Sex (of individual or offspring)
-Age of dam
-Parity of dam
-Lactation (dairy)
Term
When dealing w/performance records, what should be asked about their origin?
Definition
If there was any adjustment and how they were adjusted
Term
As geneticists, why are we interested in environmental effects and their adjustments?
Definition
In order to better remove/reduce the "environmental noise" and have a more accurate interpretation of genetically superior animals
Term
Compare and contrast additive and multiplicative adjustment factors.
Definition
Additive: linear and adds by a constant
Multiplicative: exaggerates extremes; spreads out data
Term
What is heritability?
Definition
a statistic taht estimates how much variation in a phenotypic trait is due to genetic variation among individuals.
Term
What is repeatability?
Definition
the proportion of the phenotype that is repeatable during the next production cycle
Term
What is MPPA and why is it used?
Definition
Most Probable Producing Ability: used to predict repeated performance
Term
What is EBV and why is it used?
Definition
Estimated Breeding Value: used to predict the value of the offspring
Term
What is realized heritability?
Definition
the amount of variation due to TRANSMITTABLE GENETIC EFFECTS
Term
What are the two uses of heritablity?
Definition
to predict the potential response to selection (help choose traits for selection)
Prediction of breeding value to selected individuals
Term
What is EBV and EPD and how are they different?
Definition
EBV: Estimated Breeding Value; the deviation from the average
EPD: Expected Progeny Value; the portion of the parent breeding value passed on to the offspring

EBV=EPD*2
EPD=PTA (Predicted Transmitting Ability)
Term
What is the inbreeding coefficient and what is its use?
Definition
the percent of loci which have both alleles identical by descent.
Useful because animals w/more genes in common will have similar phenotypes (both positive and negative)
Term
What is the relationship coefficient and what is its use?
Definition
the percent of alleles in TWO DIFFERENT INDIVIDUALS which are identical by descent.
Useful in selecting animals to breed across generations to prevent/manage inbreeding
Term
In the Bx equation, what does h^2 mean?
Definition
Heritability
Term
In the Bx equation, what does n mean?
Definition
Number of records
Term
In the Bx equation, what does a mean?
Definition
Number of relatives
Term
In the Bx equation, what does Rxy mean?
Definition
Relationship of the source to the animal calculating
Term
In the Bx equation, what does Rxx mean?
Definition
Relationship between source animals
Term
In the Bx equation, what does C^2 mean?
Definition
Environmental effect
Term
What does P bar mean?
Definition
Mean of (source animal x or i; herd)
Term
How is records adjustment used?
Definition
(gain/day)[adjustment factor days]
Term
Explain selection.
Definition
controlling reproduction of individuals w/in a population
Term
Explain selection intensity.
Definition
how hard a certain trait or performance level is selected for, ruling out less superior animals for breeding
Term
Why is individual record the best single source of information?
Definition
because it has an accuracy of 1 in the accuracy equation
Term
What is BLUP?
Definition
Best Linear Unbiased Prediction: uses all data available to predict EBV
Term
What is MPPA?
Definition
a measure of repeated performance of production.
Term
What is EBV?
Definition
a prediction of the deviation above/below average production
Term
What causes genetic correlation?
Definition
Pleiotrophy: same genes acting on several characters
Linkage: genes closely associated on chromosomes
Term
When dealing w/multiple sources for breeding value information, why can't the breeding values be estimated for each source and then added together?
Definition
relationships between individuals and sources as well as inbreeding coefficients are not taken into account
Term
When would using a correlated source of information be more beneficial than measuring the trait itself?
Definition
When the trait is uneconomical to measure (feed consumption and conversion)
In instances of high correlation (pubertal teste size and maternal traits)
Term
How is accuracy used in deciding breeding?
Definition
Higher accuracy renders a lesser chance for deviation of the parent EBV, but with lower accuracy there is an equal chance to have offspring with a higher or lower EBV than possible with high accuracy
Term
Why is it poor practice to multiply EPD by accuracy?
Definition
Accuracy is already accounted for when determining breeding values
Term
How can accuracy of an EBV be increased?
Definition
by obtaining more offspring data
Term
What are reference sires and what is their purpose?
Definition
Reference sires: serve as benchmarks to connect herds.
More reference sires = more connectivity and more accuracy
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