Term
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Definition
| carbonic anhydrase inhibitor--inhibits NaHCO3 reabsorption in proximal tubule (glaucoma, altitude sickness, epilepsy, overdoses, metabolic alkalosis) |
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Term
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Definition
| osmotic diuretic in proximal tubule and descending limb (oliguric acute renal failure, glaucoma, overdoses) |
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Term
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Definition
| loop diuretic--inhibits Na-K-2Cl symport in thick ascending limb (CHF, pulmonary edema, hypertension, hypercalcemia, edema of nephrotic syndrome, edema with liver cirrhosis, overdoses, treat hyponatremia when administered with hypertonic saline) |
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Term
| ethacrynic acid (edecrin) |
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Definition
| loop diuretic--inhibits Na-K-2Cl symport in thick ascending limb (CHF, pulmonary edema, hypertension, hypercalcemia, edema of nephrotic syndrome, edema with liver cirrhosis, overdoses, treat hyponatremia when administered with hypertonic saline) |
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Term
| hydrochlorothiazide (microzide) |
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Definition
| thiazide diuretic--inihibits Na-Cl symport in early distal convoluted tubule (edema of heart failure, 1st line for hypertension, prevent Ca nephrolithiasis and osteoporosis, nephrogenic diabetes insipidus, ascites from liver cirrhosis) |
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Term
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Definition
| thiazide diuretic--inihibits Na-Cl symport in early distal convoluted tubule (edema of heart failure, hypertension, prevent Ca nephrolithiasis and osteoporosis, nephrogenic diabetes insipidus, ascites from liver cirrhosis) |
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Term
| chlorthalidone (thalitone) |
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Definition
| thiazide diuretic--inihibits Na-Cl symport in early distal convoluted tubule (edema of heart failure, 1st line for hypertension, prevent Ca nephrolithiasis and osteoporosis, nephrogenic diabetes insipidus, ascites from liver cirrhosis) |
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Term
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Definition
| strongest thiazide diuretic--inihibits Na-Cl symport in early distal convoluted tubule (edema of heart failure, 1st line for hypertension, prevent Ca nephrolithiasis and osteoporosis, nephrogenic diabetes insipidus, ascites from liver cirrhosis) -doesnt increase LDL/cholesterol |
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Term
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Definition
| K sparing diuretic--inhibits Na channels in principal cells of collecting duct (combo with other diuretics for edema from CHF, hepatic cirrhosis, hyperaldosteronism, and hypertension; Liddle's syndrome (pseudohyperaldosteronism)) |
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Term
|
Definition
| K sparing diuretic--inhibits Na channels in principal cells of collecting duct (combo with other diuretics for edema from CHF, hepatic cirrhosis, hyperaldosteronism, and hypertension; Liddle's syndrome (pseudohyperaldosteronism); cystic fibrosis) |
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Term
| spironolacatone (aldactone) |
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Definition
| K sparing diuretic--nonselective aldosterone receptor blocker (combo with other diuretic for edema of CHF and cirrhosis; hypertension; hyperaldosteronism) |
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Term
|
Definition
| K sparing diuretic--selective aldosterone receptor blocker (combo with other diuretic for edema of CHF and cirrhosis; hypertension; hyperaldosteronism) |
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Term
|
Definition
| K sparing diuretic--aldosterone receptor blocker (combo with other diuretic for edema of CHF and cirrhosis; hypertension; hyperaldosteronism; in some birth control pills--yasmin) |
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Term
| desmopressin acetate (arginine vasopressin, DDAVP, stimate) |
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Definition
| synthetic ADH (nocturnal enuresis due to central diabetes insipidus) |
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Term
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Definition
| adrenergic neuron inhibitor--depletes NE in periphery--decreases CO and TPR (hypertension) |
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Term
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Definition
| adrenergic neuron inhibitor--central alpha2 agonist--decrease TPR and renin (hypertension during pregnancy) |
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Term
|
Definition
| adernergic neuron inhibitor--central alpha2 agonist--decrease TPR and renin (patch for primary hypertension) |
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Term
|
Definition
| alpha1 receptor blocker--decrease TPR (short acting for hypertension) |
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Term
|
Definition
| alpha1 receptor blocker--decrease TPR (long acting for hypertension) |
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Term
|
Definition
| alpha1 receptor blocker--decrease TPR (long acting for hypertension) |
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Term
|
Definition
| non-selective beta blocker--decrease contractility and renin--high lipid solubility (hypertension, prevention of angina) |
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Term
|
Definition
| non-selective beta blocker--decrease contractility and renin (hypertension, prevention of angina) |
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Term
|
Definition
| non-selective beta blocker--decrease contractility and renin (hypertension, prevention of angina) |
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Term
|
Definition
| non-selective beta blocker w/ ISA--decrease contractility, renin, and TPR (hypertension) |
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Term
|
Definition
| B1 blocker--decrease contractility and renin (hypertension, prevention of angina) |
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Term
|
Definition
| B1 blocker--decrease contractility and renin (hypertension, prevention of angina) |
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Term
|
Definition
| B1 blocker w/ ISA--decrease contractility, renin, and TPR (hypertension) |
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Term
|
Definition
| alpha1 and non-selective beta blocker w/ ISA--mainly decrease in TPR (severe primary hypertension and hypertensive emergencies) |
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Term
|
Definition
| NO releasing beta1 blocker--decrease TPR and CO (hypertension) |
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Term
|
Definition
| dilates arterioles (hypertension) |
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Term
|
Definition
| dilates arterioles--opens ATP-sensitive K channels (severe hypertension in renal patients) |
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Term
|
Definition
| calcium channel blocker--decrease contractility (hypertension, especially for elderly and AA's, and high Na intake, prevention of all forms of angina) |
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Term
|
Definition
| calcium channel blocker--decrease contractility (hypertension, especially for elderly and AA's, and high Na intake, prevention of all forms of angina) |
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Term
| nifedipine (procardia-XL) |
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Definition
| calcium channel blocker--decrease TPR (hypertension, especially for elderly and AA's, and high Na intake, pulmonary hypertension, prevention and acute treatment of angina) |
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Term
|
Definition
| calcium channel blocker--decrease TPR (hypertension, especially for elderly and AA's, and high Na intake) |
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Term
|
Definition
| calcium channel blocker--decrease TPR (hypertension, especially for elderly and AA's, and high Na intake, prevention and acute treatment of angina) |
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Term
|
Definition
| ACE inhibitor--decrease TPR, aldosterone, increase bradykinin (hypertension, especially those w/ diabetic nephropathy) |
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Term
|
Definition
| ACE inhibitor--decrease TPR, aldosterone, increase bradykinin (hypertension, especially those w/ diabetic nephropathy) |
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Term
| lisinopril (prinivil, zestril) |
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Definition
| ACE inhibitor--decrease TPR, aldosterone, increase bradykinin (hypertension, especially those w/ diabetic nephropathy) |
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Term
|
Definition
| ACE inhibitor--decrease TPR, aldosterone, increase bradykinin (hypertension, especially those w/ diabetic nephropathy or renal insufficiency) |
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Term
|
Definition
| ACE inhibitor--decrease TPR, aldosterone, increase bradykinin (hypertension, especially those w/ diabetic nephropathy) |
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Term
|
Definition
| ACE inhibitor--decrease TPR, aldosterone, increase bradykinin (hypertension, especially those w/ diabetic nephropathy) |
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Term
|
Definition
| Angiotensin receptor blocker--decrease TPR and aldosterone (hypertension, especially those w/ diabetic nephropathy) |
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Term
|
Definition
| Angiotensin receptor blocker--decrease TPR and aldosterone (hypertension, especially those w/ diabetic nephropathy) |
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Term
|
Definition
| Angiotensin receptor blocker--decrease TPR and aldosterone (hypertension, especially those w/ diabetic nephropathy) |
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Term
|
Definition
| renin inhibitor--decrease TPR and aldosterone (hypertension, especially those w/ diabetic nephropathy) |
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Term
|
Definition
| B1 blocker (hypertensive emergency) |
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Term
| nitroglycerin (minitran, nitrostat) |
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Definition
| activate guanylyl cyclase--increase cGMP--smooth muscle relaxation and decreased preload (prevention and acute treatment of all types of angina) |
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Term
| isosorbide dinitrate (isordil) |
|
Definition
| activate guanylyl cyclase--increase cGMP--smooth muscle relaxation and decreased preload (prevention and acute treatment of all types of angina) |
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Term
|
Definition
| fatty acid oxidation inhibitor--inhibits late inward sodium current? (chronic stable angina) |
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Term
|
Definition
| cholesterol absorption inhibitor--inhibits specific protein-mediated transport--decreases LDL (high LDL type hyperlipoproteinemias) |
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Term
| cholestyramine (questran) |
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Definition
| bile acid binding resins--exchange chloride for bile acids--decrease LDL (high LDL type hyperlipoproteinemias) |
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Term
|
Definition
| bile acid binding resins--exchange chloride for bile acids--decrease LDL (high LDL type hyperlipoproteinemias) |
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Term
|
Definition
| bile acid binding resins--exchange chloride for bile acids--decrease LDL (high LDL type hyperlipoproteinemias) |
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Term
|
Definition
| HMG-CoA reductase inhibitor--most effective at lowering LDL, also decreases VLDL and IDL (elevated LDL cholesterol, antiinflammatory) |
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Term
|
Definition
| HMG-CoA reductase inhibitor--most effective at lowering LDL, also decreases VLDL and IDL (elevated LDL cholesterol, antiinflammatory) |
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Term
|
Definition
| HMG-CoA reductase inhibitor--most effective at lowering LDL, also decreases VLDL and IDL (elevated LDL cholesterol, antiinflammatory) |
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Term
|
Definition
| HMG-CoA reductase inhibitor--most effective at lowering LDL, also decreases VLDL and IDL (elevated LDL cholesterol, antiinflammatory) |
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Term
|
Definition
| HMG-CoA reductase inhibitor--most effective at lowering LDL, also decreases VLDL and IDL (elevated LDL cholesterol, antiinflammatory) |
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Term
|
Definition
| fibrate--increased lipoprotein lipase via increased PPAR alpha--decrease VLDL and triglycerides (primary hyperlipidemias w/ high VLDL, hypertriglyceridemia secondary to apolipoprotein E defect) |
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Term
| fenofibrate (tricor, triglide) |
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Definition
| fibrate--increased lipoprotein lipase via increased PPAR alpha--decrease VLDL and triglycerides (primary hyperlipidemias w/ high VLDL, hypertriglyceridemia secondary to apolipoprotein E defect) |
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Term
|
Definition
| inhibits intracellular lipolysis in fat cells (hormone sensitive lipase)--decreases VLDL and lipoprotein, increases HDL (primary type hyperlipidemias and patients w/ HDL deficiency) |
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Term
| omega-3-acid ethyl esters (lovaza) |
|
Definition
| inhibit hepatic synthesis of triglycerides (adjunct to diet in patients w/ high plasma triglycerides, decreases VLDL, antiinflammatory) |
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Term
|
Definition
| oligonucleotide type inhibitor--inhibits apolipoprotein B formation--decreases VLDL and LDL (homozygous familial hypercholesterolemia) |
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Term
|
Definition
| microsomal triglyceride transfer protein type inhibitor--inhibits apolipoprotein B formation--decreases VLDL and LDL (homozygous familial hypercholesterolemia) |
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