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Definition
- microbial infection of the blood - bacteremia or toxemia - septic shock= low blood pressure resulting from dilation of blood vessels, decrease in body temp, no urine, rapid breathing,anxiety, increased heart rate cause: different bacteria classic sign: low blood pressure, leads to shock, petechiae indicates toxin present, lymphangitis indicates infection of lymphatic system other: GI tract symptoms, fever, chills, nausea, vomiting, shortness of breath, confusion, anxiety, impending doom feeling *opportunistic and often gram negative 2 types |
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toxins in blood (septicemia) |
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septic shock= low blood pressure resulting from dilation of blood vessels, decrease in body temp, no urine, rapid breathing,anxiety, increased heart rate cause: different bacteria classic sign: low blood pressure, leads to shock, petechiae indicates toxin present, lymphangitis indicates infection of lymphatic system other: GI tract symptoms, fever, chills, nausea, vomiting, shortness of breath, confusion, anxiety, impending doom feeling *opportunistic and often gram negative 2 types |
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indicates infection of lymphatic system, red streaks |
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indicate toxin present in septicemia |
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inflammation of endocardium acute- not chronic (normal microbiota) chronic/ subacute- severe (streptococcus) cause: differs signs: splinter hemorrhages in nails, heart murmur, extreme fatigue, fever, malaise, heart murmurs, difficulty breathing, destruction of heart valves pathogens: 1. low virulence streptococci (chronic/ rheumatic fever) enters from previous heart valve damage 2. staphylococcus aureus, s epidermidis (acute)- people otherwise healthy, enters from infected tooth, skin lesion, catheter, or drug use 3 others: happens with trauma, surgery, infection, or drug users *vegetations= damage to valves
Normally, blood flows smoothly past these valves. If they have been damaged (from rheumatic fever, for example) the risk of bacteria attachment is increased.[2] |
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found in patients with endocarditis on nails |
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progressive disease leading to severe arthritis (not fatal) transmitted by a tick, bulls eye rash and severe fatigue
cause: borrelia burgdorfei (bacteria)
stage 1: expanding red rash (bulls eye) in 80%, malaise, headache, dizziness, stiff neck, fatigue, fever, chills stage 2: neurological symptoms and cardiac dysfunction (10%) stage 3: severe arthritis (80%)
- antibiotics to treat |
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caused by EBV (epstein barr virus), extreme fatigue, enlarged nodes and spleen, "THE KISSING DISEASE"
signs: severe sore throat, fever, enlarged spleen and lymph nodes, extreme fatigue, nausea, loss of appetite, rash.
transmitted: direct/indirect contact and droplets
*B cells are infected !!! so Tc cells target and killthem - supportive treatment, no contact sports due to danger of enlarged spleen - nearly impossible to prevent
pathogen: epstein barr virus (EBV or HHV-4) |
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african viral hemorrhagic fevers |
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Definition
- ebola virus -marburgvirus
signs: FEVER, fatigue, dizziness, muscle pain, exhaustion, minor petechiae, severe INTERNAL HEMORRHAGING AND BLEEDING, death from shock, seizures, kidney failure
cause: infected macrophages trigger localized blood clotting depleting serum of blood clotting proteins
ebola virus: 90% fatal, marbugvirus= 25% fatal
transmitted by bodily fluid contact, supportive treatment |
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Definition
plasmodium PROTOZOAN, caused by different species, transmitted through infected mosquito, SEVER AND RECURRENT FEVER AND CHILLS, JAUNDACE 1. liver cells infected, grow and rupture letting organisms in to blood stream 2. RBCs infected next through stages and eventually are ruptured and released again. RING SHAPED RBC TO DIAGNOSE 3. more RBCs infected after rupture
symptoms: plasmodium in blood stream, HIGH FEVER, chills, shaking IN CYCLES (every 48-72 hrs)
CAN BE FATAL
cellular debris and RBC protein in blodo impacts how liver and kidneys function * jaundace and dark urine seen *strokes, heart attacks |
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Definition
second stage of malaria in which rbis that are infected are ruptured (seen as ring shape) |
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Definition
cause: toxoplasma gondii (PROTOZOAN) sign: BLINDNESS, 80% asymptomatic, with poor immunity however fever, malaise, inflammation of lungs, headache, confusion, blindness, myocarditis, encephalitis and death casued by:eating contaminated meats PORK AND BEEF or also from KITTY LITTER (pathogen of rodents) transplacental transfer may cause epilepsy, mental retardation, microcephaly , eye infection, still birth,jaundice, miscarriage
ANTIPROTOZOAN TREATMENT avoid contact |
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Definition
WORM/ helminthic (shistosoma) classic sign: dermatitis where they have burrowed in skin cause: con tam water, spiny eggs seen in feces, known as swimmers itch or snail fever *antihelmithic treatment
1. larvae burrow into tissue and gain access to blood stream 2. spots of dermatitis seen (itching) 1st indication 3. leaves human in feces and urine where it is picked up by snail and formed there and is then re released |
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gram positive cause strep throughout |
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an african viral hemorrhagic fever |
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an african viral hemorrhagic fever |
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causes malaria (PROTOZOAN) |
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Definition
causes toxoplasmosis (PROTOZOAN) |
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Definition
causes shistosomiasis (PARASITIC WORM) |
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streptococcal pharyngitis |
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Definition
-strep throat -bacterial upper disease cause: streptococcus pyrogenes (bacteria)(gram positive cocci) virulence factors: m protein, capsule, streptokinases, c4a peptidase, erthrogenic toxin, streptolysins
transmitted: droplets
classic sign: tonsil abscesses also: swollen lymph nodes, laryngitis, bronchitis, scarlet fever if erythrogenic toxin is made, rheumatic fever if untreated, |
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Definition
cause: streptococcus pyrogenes (bacteria) classic sign: systemic rash other: follows strep throat, erythrogenic toxin, lysogenized |
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Definition
develops with pain in heart and joints from untreated step causing heart valve damage predisposes you to subacute endocarditis causes chronic endocarditis - predisposed - damages heart valve |
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Definition
toxin released by streptococcus pyrogenes during strep throat causing scarlet fever |
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Definition
irritation of larynx due to bacteria from strep spreading from pharynx to larynx |
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Definition
inflammation of bronchiole tubes |
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Definition
pathogen: corynebacterium diptheriae, *THE DIPTHERIA TOXIN RELEASED MUST BE LYSOGENIZED
signs: sore throat, PSEUDOMEMBRANE, localized pain and fever, pahryngitis, oozing fluid leading to pseudomembrane
transmisison: droplet tratment: antitoxin and antibiotics prevention: VACCINE!!! Dtap |
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Definition
large pus patch on throat from diphtheria |
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Definition
bacterial upper disease, toxin that is released (corynebacterium diphtheria, must be lysogenized) causing sore throat, pain ,fever, oozing pseudomembranes |
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Definition
bacterial upper disease sinus infection signs: pain, pressure in sinus area usually caused by normal microbiota of throat
pathogenesis: pharynx to sinuses through connections with the throat canal
antibiotics |
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Definition
ear infection signs: severe pain in ears usually caused by normal microbiota of throat pathogenesis: pharynx to ears through connections bacterial upper disease with the ear canal
antibiotics |
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Definition
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Definition
>200 viruses upper viral disease dry cough**** sneeze, runny nose, congestion, sore throat, dry cough, maybe no caught, USUALLY NO FEVER kils nasal mucosal cells |
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Definition
- bacterial lower disease - inflammation of the lungs, alveoli, and bronchioles become filled with fluid - caused by streptococcus pneumonia (OPPORTUNISTIC!!! member of normal microbiota
signs: fever, chills, congestion, PRODUCTIVE COUGH, chest pain, rapid breathing
virulence: capsule, with pneumolysin
pathogenesis: inhaled from pharynx to lungs, opportunistic
antibiotics, vaccine against pneumococcus |
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Definition
pneumonia caused by bacteria streptococcus pneumoniae |
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Definition
KILLS CILIATED EPITHELIAL CELLS Pneumolysin is a putative virulence factor of the gram-positive bacteria Streptococcus pneumoniae. It is a pore-forming toxin of 53 kDa composed of 471 amino acids. It has a range of biological activity, including the ability to lyse and interfere with the function of cells and soluble molecules of the immune system. |
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Definition
cause: mycobacterium tuberculosis asymptomatic!!!!!!!
*macrophages infected, tubercule formation, dif stages primary-no signs, macrophages infected, tubercle formed, primary ends once its formed secondary- tuburcle ruptures possibly becomes disseminated, productive cough and blood and weight loss begin diseminated- (has left lungs causing infection and disease, macrophages left lungs)
skin test: if the skin is red/swollen this means the immune system has memory cells and has been exposed before (so either you have been exposed OR have had the vaccine which is not usually given in US) - doctor will take chest X-ray to look for tubercle which will always be present in the case of tb |
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Term
primary/secondary/disseminated tuburculosis |
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Definition
primary- no signs, ends when tubercle formes secondary- tubercule is there and ruptures, cough with blood and production and chest pain diseminated- macrophages leave lungs |
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Term
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Definition
whooping coug, reemerging disease (children under 5 may be a fatal disease)
cuase: bordetella pertusis bacteria, produced pertusis toxin (cytotoxin) creating excessive mucous production
signs: prolonged cough followed by inhalation, begins with runny nose, mild fever, after 1-2 weeks vomitting, diarrhea, choking, cyanosis
SUPPORTIVE treatment because antibiotics will release toxins possibly making it worse |
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Definition
also called cytotoxin, creates excessive mucous production in pertusis/whooping cough |
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Term
influenza virus HA and NA spikes |
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Definition
- viral lower disease -dry cough, sudden high fever, myalgia - influenza virus A and B most common -8 RNA molecules make up the genome- genetic material tell it how to make spikes on surface called HA and NA spikes - hemagglutinin (HA) and neuraminidase(NA) spikes- on surface and important for virus attachment and is what immune system responds to
GENETIC VARIABILITY antigenic drift- respiratory cells become infected by virus, as virus is going through synthesis there are mutations and changes to the genes, so what exits the cell is a slightly different virus (genetically different and spikes are different) (small change, minor) (account for minor outbreaks winter to winter) *BOTH A and B undergo shift
antigenic shift- a major change to a very severe influenza, when pigs, birds, and people are living very closely together it creates a melting pot of influenza viruses. A cell becomes infected by virus 1 and virus 2, a third virus comes out of the respiratory cell (so they viruses are basically mixed) * 2 viruses enter>>> a 3rd is formed **ONLY INFLUENZA A UNDERGOES THE SHIFT (viruses are renames when they shift, named by their spikes changing) (more severe in under 2, over 65, or pregnant women (dangerous to pregnant lady, not baby) ) 1918-1919: 20-40% of people became ill, 40 million died ( we heard the bells) (young and healthy people died 20-50)
CHEMICALS RELEASED FROM IMMUNE SYSTEM CAUSE SYMPTOMS RESPIRATORY EPITHELIAL CELLS ARE KKILLED
VACCINE AVAILABLE |
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Term
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Definition
antigenic drift- respiratory cells become infected by virus, as virus is going through synthesis there are mutations and changes to the genes, so what exits the cell is a slightly different virus (genetically different and spikes are different) (small change, minor) (account for minor outbreaks winter to winter) *BOTH A and B undergo shift |
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Term
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Definition
antigenic shift- a major change to a very severe influenza, when pigs, birds, and people are living very closely together it creates a melting pot of influenza viruses. A cell becomes infected by virus 1 and virus 2, a third virus comes out of the respiratory cell (so they viruses are basically mixed) * 2 viruses enter>>> a 3rd is formed **ONLY INFLUENZA A UNDERGOES THE SHIFT (viruses are renames when they shift, named by their spikes changing) (more severe in under 2, over 65, or pregnant women (dangerous to pregnant lady, not baby) ) 1918-1919: 20-40% of people became ill, 40 million died ( we heard the bells) (young and healthy people died 20-50) |
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Term
RSV and tracheobronchtis (croup) |
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Definition
respiratory synctial virus - most common childhood respiratory disease in newborns and young children - fever, runny nose, CYANOSIS, coughing, wheezing - most common cause of bronchiolitis or pneumonia and may cause CROUP- fever and distinct cough and wheezing only in children - pathogenesis: - causes giant, multinucleate cells to form (SYNCTIAL) - immune responses also damage the lungs
treat: - antibodies would be given from treatment whichh neutralize the virus present - proper ascetic technique by HCW |
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Definition
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Term
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Definition
bacteria that causes strep throat, scarlet fever, and rheumatic fever |
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Term
corynebacterium diphtheria |
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Definition
bacteria causes diphtheria |
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Term
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Definition
bacteria causes pneumonia |
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Term
mycobacterium tuberculosis |
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Definition
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Definition
bacteria causes whooping cough |
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Definition
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Definition
(tracheobronchitis)- RSV virus causes this barking coug, wheezing, labored breathing in children--- leads to CROUP in newborns/young, cyanosis
ANTIBODIES GIVEN |
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Term
histoplasma capsulatum (MYCOSES) |
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Definition
fungal infection/mycoses - sever cough, blood tinged sputum - bird/bat droppings/vehicle transmission cause: histoplasmosis, a fingu that is dimorphic (found as yeast as well s mold depending on conditions MORE LIKELY YEST) - 95% asymptomatic
infected macrophages carry pathogen outside of lungs |
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Term
normal microbiota are present where |
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Definition
tongue, colon, teeth, jejenum, ileum, rectum
NOT MANY in esophagus, stomach, duodenum (due to peristalsis and stomach acid) |
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Term
how do normal microbiota help |
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Definition
- compete with pathogens for space and nutrients - help ward off IBS, Crohns disease - alleviate symptoms of gastroenteritis - may shorten the duration of colds by 36 hours - mediates whether a person is obese or lean |
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Term
Why does use of antibacterial drugs over an extended time increase the likelihood of oral candidiasis (thrush) and so-called C. diff diarrhea? |
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Definition
- because it kills off normal microbiota allowing yeast to flourish |
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Term
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Definition
Caries – holes or pits in teeth; initially painless but teeth become increasingly sensitive * biofilm formation and fermentation |
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Term
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Definition
swollen and/or bleeding gums, tender and bright red gums *progresses from gingivitis |
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Term
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Definition
Streptococcus mutans and Lactobacillus- both normally present in mouth, but our lifestyle allows them to cause these diseases **** they use sucrose as a nutrient source… dextran is made as a byproduct allowing organisms to stick to teeth allowing microbes to form biofilm and then plaque |
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Term
strep mutans and lactobacillus are |
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Definition
microbiota in mouth that use sucrose as nutrient source and make dextran which allows them to stick to teeth |
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Term
______ and adhesion factors allow for biofilm formation; fermentation produces acid that destroys enamel |
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Definition
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Term
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Definition
dental calculus [calcified plaque] at gum line triggers gingivitis; if not corrected, further tissue destruction occurs along with bone loss |
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Term
Bacterial Gastroenteritis |
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Definition
- inflammation of stomach or intestines caused by bacteria
shigella- causes shigellosis- type of gastroenteritis ( transmitted by food or water that has fecal contamination) often opportunistic infection signs: fever, abdominal cramps, diarrhea, BLOODY STOOL!!!!
-clostridum difficile- normal microbiota, severe diarrhea or PSEUDOMEMBRANES IN COLON (pseudomembrane colitis)
* often noscomial infection due to antibiotics due to clostridium making endospores in poop, so cleaning rooms is important
*fecal microbiota transplant *fluid and electrolyte replacement treatment *prevent by proper handling of food |
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Term
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Definition
(type of bacterial gastroenteritis) shigella- causes shigellosis- type of gastroenteritis ( transmitted by food or water that has fecal contamination) often opportunistic infection
BLOODY STOOL! dysentery, cramps, fever |
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Term
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Definition
type of bacterial gastroenteritis -clostridum difficile- normal microbiota, severe diarrhea or PSEUDOMEMBRANES IN COLON (pseudomembrane colitis) ENDOSPORE FORMER, oportunistic !!!! * often noscomial infection due to antibiotics due to clostridium making endospores in poop, so cleaning rooms is important
*fecal microbiota transplant *fluid and electrolyte replacement treatment *prevent by proper handling of food |
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Term
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Definition
type of bacterial gastroenteritis - not normal microbiota, ingested from fecal matter from some animal chicken eggs, reptiles *fever, cramps, WATERY DIAREHEA |
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Term
bacterial food intoxications |
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Definition
-food poisoning caused by toxins, microbe is either present or not present (ingesting toxin like food borne botulism) - signs: nausea VOMITING, diarreha, cramping, bloating, fever, FLUID LOSS AND DEHYDRATION
pathogen= staphlococcus aureus that must produce enterotoxin
processed meats, custard pies, potatoe salad, ice cream, higher sugar foods - contamination when it is at room temp or higher for several hours
fluid and electrolyte replacement |
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Term
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Definition
-generally less severe than bacterial gastroenteritis
symptoms: abdominal pain, cramping, diarrhea, nausea, vomiting, fver, chills clammy skin, weight loss
noroviruses (a calicivirus)- in adults mostly (most common form)
rotaviruses- much more severe and common in young children less than 5 (vaccine now)
pathogenesis: infects cells lining the intestinal tract, as those cells die the normal function of intestinal tract is lost
FLUID AND ELECTROLYTE REPLACEMENT |
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Term
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Definition
- inflammation of liver by autoimmune disease, alcohol or drug abuse, genetic disorders, or microbial infections liver stops functioning from virus as well as immune response
symptoms: jaundice, light colored stools, nausea, vommiting, fatigue, fever, weight loss
typs: HAV- fecal/oral (food preperation) doesn't become chronic and doesn't lead to cancer *if exposed vaccine given because 15-45 day incubation
HBV- needles, sex, blood, fluids * chronic and may cause hepatic cancer *NEWBORNS and children under 5 most likely to become chronic AGE RELATED!!! *vaccine
HCV- needles, sex *chronic, hepatic cancer *NOT AGE RELATED, 80% chance of it being chronic and leading to liver cancer because the virus undergoes a lot of genetic mutations and defenses can't keep up. NO CURE
treatment: antibodies, interferon, NO CURE
vaccine fror HAV and HBV |
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Term
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Definition
hep a- fecal/oral transmission, not chronic, no cancer, vaccine may be given because incubation is 15-45 days treat: antibodies, interferon |
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Term
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Definition
hep b- needles, sex, blood, fluids *chronic and may cause hepatic cancer *newborns and children less than 5 most likely to become chronic , AGE RELATED, VACCINE AVAILABLE
treat: antibodies, interferon, |
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Term
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Definition
hep c- needles, sex *chronic, hepatic cancer, NOT AGE RELATED, no cure, genetic changes and defenses can't keep up 80% chance of being chronic
treat: antibodies,interferon, no cure |
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Term
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Definition
cause: giardia (protozoan)
severe frothy, fatty diarrhea with rotten egg smell
FROM backpacking, camping, contaminated fresh water, pets |
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Term
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Definition
parasitic worm -taenia helminthic worm - usually asymptomatic, maybe cramps, nausea, weight loss, diarrhea BEEF AND PORK
antihelminthic treatments
COOK THOROUGHLY - beef and pork, ingest eggs or proglottids
has hooks, suckers, necks, and segments called proglottid with eggs!!! |
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Definition
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Term
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Definition
enterobius (parasitic wormm) intense perianal itching, sleep disturbance, school aged children, dislodge eggs from scratching, female moves to anus (from colon) at night depositing eggs personally |
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Term
what is a dental calculus |
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Definition
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Term
contrast gastroenteritis and food intoxication |
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Definition
gastroenteritis is an infection of the GI tract while food intoxication is from ingesting a toxin on food. incubation for gastro may be a few days while food intoxication can be as quick as 30 mins |
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Term
HBV and HCV and role of immune |
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Definition
when hbv infection occurs at a young age, the immune system is not developed enough to clear the virus. HCV undergoes genetic changes, changing the antigens which confuses the immune system and stops it from clearing |
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Term
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Definition
escherichia coli - frequent urgent need to urinate and painful - urethritis(ut inflammation), cystitis (bladder inflammation), pyelonephritis(bacteria in kidney), common HAI |
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Term
streptococcal acute glomerulonephritis |
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Definition
-streptococcus pyrogenes -inflammation of the glomeruli and nephrons of kidneys -antigen- antibody complexes accumulate leading to inflammation SIGNS: high blood pressure, low urine output, blood and proteins in urine |
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Term
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Definition
-staphylococcus aureus causes! - toxic shock syndrome toxins (TSSTS) - sudden onset of fever, chills, vommiting, diarrhea, low BP, mental confusion, Severe rash 50% fatality rate if untreated -TSSTS cause activation of T cells resulting in an over abundance of cytokines -prolonged use of tampons, or surgery packing
MEDICAL EMERGENY- remove, antibiotics, anti TSST IG |
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Term
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Definition
- gardnerella, mycoplasma - vaginal itching, white discharge with fishy odor - vaginal pH >4.5 (due to lactobacilli decreasing) - sometimes asymptomatic - oral or vaginal antibiotics |
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Term
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Definition
- candida fungus -white curd like discharge, sever itching and burning(worse on urination) -occurs when norm or microbiota are altered or ph>4.5 -topical or oral antifungal treatments - oportunistic |
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Term
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Definition
neusseria gonorrhoeae (fimbriae, capsule, endotoxin, protease enzyme (destroys IgA)
- infects cervix, can attach to sperm cells that carry Ng to uterine tubes
ANTIBIOTICS- resistance is a problem - no long term immunity - sexual abstinance, monogamy, and use of condoms prevent
men- painful urination, discharge women- painful urination, bloody discharge , but often asymptomatic
*CAN LEAD TO PID |
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Term
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Definition
treponema pallidum 1. chancre- painless hard lesion 2. rash, palms/soles- doesn't itch or hurt (may have sore throat or mild fever) 3. dementia, blindness, paralysis, heart failure, or syphilitic gummas (rubbery swollen lesions in bones, nervous tissue, or skin) LATENT- may have no symptoms
PENICILLIN G
progression, especially in absence of treatment |
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Term
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Definition
signs/symptoms: numerous small blisters that break out and become painful ulcers -pathogens: HHV (85% caused by HHV-2) latent virus - blisters from when viral replication kills epithelial cells -latent viruses may trigger recurrent lesions - asymptomatic periods will still result in transmission of virus
TREATMENT - acycovir, can relieve and lessen blister formation but no cure - C section necessary if blisters at birth |
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Term
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Definition
various strains of HPV cause it - generally harmless growths of epithelial cells -small or large - may be itchy, bleed or increase vaginal discharge
TreatmentL Tc cells eventually recognize and destroy infected cells, or surrey, freezing, burning, laser, or chemicals
PREVENT -pap smear (linked to cervical cancer) - vaccine- protects from HPV |
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Term
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Definition
trichomonas vaginalis (protozoan) - women have malodorous yellow- green discharge, dysuria - men: urethritis BOTH MUST BE TREATED with ANTIPROTOZOAN |
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Term
what diseases have toxins |
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Definition
- septicemia (if petichiae are present) -streptococcus pyrogenes releses erythrogenic toxin -diptheria (toxin must be lysogenizeD) |
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Term
endocarditis causes and whether they are acute or chronic |
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Definition
streptococcus= chronic staphylococcus aureus, s epidermidis = acute |
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Term
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Definition
1. red bulls eye, malaise, stick neck, headache,dizziness,fever,chills 80% 2. neurological symptoms and cardiac disfunction 10% 3. severe arthritis 80% |
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Term
EBV causes what/ epstein barr virus |
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Definition
infectious mononucleosis (kissing disease)
signs: severe sore throat, fever, enlarged spleen and lymph nodes, extreme fatigue, nausea, loss of appetite, rash. |
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Term
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Definition
plasmodium protozoan causes malaria
fever chills and shaking in CYCLES, jaundice, liver cells affected and ruptured, red blood cells affected and rupture to a RING SHAPE!!!!!,
cellular debris and RBC protein in blodo impacts how liver and kidneys function * jaundace and dark urine seen *strokes, heart attacks |
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Term
which diseases are protozoans |
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Definition
plasmodium, toxoplasmosis(kitty litter/pork n beef), giardia |
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Term
which disease is a parasitic worm |
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Definition
shistosomiasis- dermatitis, spiny eggs in feces and urine |
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Term
what hurts when u get rheumatic fever |
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Definition
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Term
histoplasma capsulatum (MYCOSES) |
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Definition
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Term
which hepatitis is most common in kids |
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Definition
hep B.... there is a vaccine thoo |
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