Term
| Which therapeutic drug has an OD that leads to severe liver necrosis due to accumulation of free radicals? |
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Definition
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Term
| Treatment for Acetaminophen OD is effective in the first how many hours? |
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Definition
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Term
| Acetaminophen - _____ can predict liver toxicity based on serum levels |
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Definition
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Term
True or False:
Alcohol ingestion increases toxic effects of Acetaminophen |
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Definition
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Term
| Acetaminophen OD - Samples should be drawn how many hours post ingestion and monitored over a 24 period? |
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Definition
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Term
| What else should be monitored when an Acetaminophen OD occurs? |
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Definition
| Liver enzymes, bilirubin and PT |
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Term
| What are the side effects of Salicylate (Aspirin)? |
|
Definition
| GI irritation, disturbed platelet aggregation, tinnitus |
|
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Term
| What are 2 Other OTC NSAIDs? |
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Definition
|
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Term
| ____ is a possibility for any patient who is unconscious for unexplained reasons |
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Definition
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Term
True or False:
Because most drugs clear quickly, screening tests can only detect recent abuse |
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Definition
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Term
| Name 7 Drugs with a High Potential for Abuse |
|
Definition
Tranquilizers
Amphetamine/Methamphetamine
Cannabinoids
Cocaine
Opiates
Hallucinogens
Anabolic Steroids |
|
|
Term
What are the following consistent with:
CNS depressants/ anti-anxiety drugs
Barbiturates (Pentobarb, phenobarb)
Benzodiazepines (Valium, Librium, Ativan, Prozac) |
|
Definition
| Tranquilizers (Sedative-Hypnotics) |
|
|
Term
| What does OD of Tranquilizers (Sedative-Hypnotics) cause? |
|
Definition
| lethargy, slurred speech, stupor, respiratory arrest, coma |
|
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Term
What are the following consistent with:
CNS stimulants (bennies, uppers, speed)
Used to treat narcolepsy and ADD
Causes talkativeness, restlessness, tremors, psychosis |
|
Definition
| Amphetamine/Methamphetamine |
|
|
Term
What are the following consistent with:
Psychoactive compounds (primarily THC) in marijuana and hashish
Lipophilic = accumulation in brain/fat cells; slower elimination
Detected up to 5 days after single use; one month+ in chronic use
Alters mood, perception, psychomotor skills, short-term memory; paranoia |
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Definition
|
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Term
What are the following consistent with:
Local anesthetic
CNS stimulator: elicits a sense of excitement and euphoria |
|
Definition
|
|
Term
What are the following consistent with:
Used as analgesics, sedatives and anesthesia
Derived from opium poppy |
|
Definition
|
|
Term
Amphetamine/Methamphetamine - A
llergy meds contained the chemically related _____ & _______ |
|
Definition
| ephedrine & pseudoephedrine |
|
|
Term
| ___________ - amphetamine designer derivative |
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Definition
|
|
Term
| Cannabinoids - what does the current method distinguish between? |
|
Definition
| Direct Use and Passive Exposure |
|
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Term
| Marinol and medical marijuana are used to treat what? |
|
Definition
| anorexia, glaucoma, pain, and nausea associated with chemo |
|
|
Term
| OD of Cocaine is associated with what? |
|
Definition
| Seizures and heart attacks |
|
|
Term
What are the following consistent with:
LSD, PCP (Phencyclidine), Mescaline
May cause both stimulant and depressant effects
Hostility, paranoia, flashbacks |
|
Definition
|
|
Term
What are the following consistent with:
Related to testosterone; originally developed to treat male hypogonadism
Increases muscle mass and athletic performance
Hepatitis, atherosclerosis, stroke, MI, sterility, impotence
Potency of black market drugs is variable |
|
Definition
|
|
Term
|
Definition
|
|
Term
| List 3-4 Natural Modified Opiates |
|
Definition
| Heroin, Oxycodone/Dilaudid, Percodan |
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|
Term
|
Definition
|
|
Term
| What is an OD of Opiates tied to? |
|
Definition
| Respiratory acidosis and heart failure (myoglobin, CKMB and TnI) |
|
|
Term
| Which Drug with a high potential for abuse was originally developed to treat male hypogonadism? |
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Definition
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Term
Which Metal is consistent with the following:
Naturally occurring and man
-
made:
insecticides, herbicides, and treated lumber
Disrupts many proteins
GI bleeding, shock and convulsions |
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Definition
|
|
Term
Which Metal is consistent with the following:
Commercial and art paints; in pipes and on highways from car emissions
Most toxicity is from ingestion of contaminated foods
Inhibits heme and Vit D synthesis
Causes anemia (hypoxia), liver and kidney injury, bone disorders,brain dysfunction, birth defects, porphyria |
|
Definition
|
|
Term
Which Metal is consistent with the following:
Most toxicity is from contaminated foods (fish/seafood) or industrial
Binds / alters proteins
Bloody diarrhea, behavioral changes, loss of balance
If patient survives initial poisoning, renal failure often follows |
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Definition
|
|
Term
Tests to determine adulteration. General rules for urine sample validity:
Temperature |
|
Definition
|
|
Term
Tests to determine adulteration. General rules for urine sample validity:
Creatinine |
|
Definition
|
|
Term
Tests to determine adulteration. General rules for urine sample validity:
SG |
|
Definition
|
|
Term
Tests to determine adulteration. General rules for urine sample validity:
pH |
|
Definition
|
|
Term
Tests to determine adulteration. General rules for urine sample validity:
Nitrite |
|
Definition
|
|
Term
Tests to determine adulteration. General rules for urine sample validity:
Glutaraldehyde |
|
Definition
|
|
Term
|
Definition
| Heme and Vitamin D Synthesis |
|
|
Term
| What does Lead Poisoning cause? |
|
Definition
| Anemia (hypoxia), liver and kidney injury, bone disorders,brain dysfunction, birth defects, porphyria |
|
|
Term
| Most Mercury Toxicity is from where? |
|
Definition
| Contaminated foods (fish/seafood) or industrial |
|
|
Term
|
Definition
|
|
Term
| If patient survives initial Mercury Poisoning, what often follows? |
|
Definition
|
|
Term
Which Misc. Toxic Agent is associated with the following:
Incomplete combustions of fuels
Binds to hemoglobin (replaces O2) to form carboxyhemoglobin
Severe hypoxia, primarily affecting heart and brain (lactic acidosis) |
|
Definition
|
|
Term
Which Misc. Toxic Agent is associated with the following:
Gas or solid: insecticides, rat poison, burning insulation
Binds to heme iron and disrupts production of cellular ATP
Respiratory arrest, seizures, coma, death |
|
Definition
|
|
Term
Which Misc. Toxic Agent is associated with the following:
Pesticides (contaminated food/ industrial exposure)
Affects nerve synapses, causing salivation, involuntary urination and
defecation, muscle cramps, respiratory failure |
|
Definition
|
|
Term
| What does Carbon Monoxide bind to? |
|
Definition
|
|
Term
| When Carbon Monoxide binds to hemoglobin what does it replace? |
|
Definition
|
|
Term
| When Carbon Monoxide binds to hemoglobin what does it form? |
|
Definition
|
|
Term
| What does Cyanide bind to? |
|
Definition
|
|
Term
| When Cyanide binds to Heme Iron, what does it disrupt? |
|
Definition
| Production of cellular ATP |
|
|
Term
| What do Organophosphates affect? |
|
Definition
|
|
Term
| When Organophosphates affect nerve synapses, what does this cause? |
|
Definition
Salivation, involuntary urination and
defecation, muscle cramps, respiratory failure |
|
|
Term
| Hair can detect alcohol and drugs for how long after exposure? |
|
Definition
|
|
Term
True or False:
Hair AND Saliva are Impossible to adulterate |
|
Definition
|
|
Term
| What is considered the best specimen for alcohol testing? |
|
Definition
|
|
Term
| Other than alcohol, what else can Saliva detect? |
|
Definition
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