Term
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Definition
Carbonic Anhydrase Inhibitor -blocks Na and HCO reabsorp in proximal tubule
Action: Slows movement of H ions, mild diuretic
Indication: Not seen often, used for glaucoma
SE: Kidney stones (renal calculi), metabolic acidosis, hypokalemia
Contraindications: Allergies to sulfonamides
Special consideration: Older adults hypotension, rapid water loss, and diurectics may raise blood sugar levels |
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Term
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Definition
Loop diuretic: ascending loop of henle
Action: potent diuretic, blocks chloride pump, fast acting, increase Ca excretion, can produce fluid loss up to 20 lb/day
ADME: fairly well absorbed, peak 1-2 hr, t 1/2 <1 hr
Indication: Acute HF, pulmonary edema, and edema related to HF, renal, or liver disease
SE: Postural hypotension, ototoxicity, nephrotoxicity, neurotoxicity, hypokalemia (watch for muscle tremors), alkalosis, hypocalcemia and tetany
Drug-drug interactions: Lithium, NSAIDs
OD: hypovolemia, and electrolyte imbalance
Education: Positional hypotension, dietary counseling (rich in potassium), avoid sun, hearing loss, and NSAID use |
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Term
hydrochlorothiazide (HydroDIULRIL) |
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Definition
Thiazide diuretic: ascending loop of henle
Acion: blocks chloride pumps, reduces plasma and extracellular fluid
ADME: 1 to 3 hr
Indication: first line drug for HTN, mild diuretic
SE: Fluid and electrolyte imbalance, increase cholesterol and lipid balance, increased risk of digitalis toxicity
Education: supplement K or increase in diet, monitor BP, lipid, K, creatinine clearance, feel fatigue |
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Term
spironolactone (Aldactone) |
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Definition
Potassium Sparing diuretic
Used in conjunction with other diurectic
SE: hyperkalemia, androgen effects like hirsutism, gynecomastia, irregular menses, deepening voice
Drug-drug: loses its effect if used with salicylates, decreases anticoagulant effects
OD: hypovolemia, hypotension |
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Term
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Definition
Osmotic diuretic, a sugar that pulls water into the renal tubule w/out loss of sodium
Indications: increased intracranial pressure, acute renal failure due to shock, drug overdose, acute glaucoma
ADME: IV administration, t1/2 90 minutes, PO agent for glaucoma
SE: hypotension, fluid and electrolyte imbalance, CNS weakness
Contraindication: renal or cardiac dysfunction, intracranial bleeding
Nursing implications: crystillization is common, used indwelling catheter w/ urometer to measure hourly output |
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Term
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Definition
dizziness, confusion, insatiable thirst, salt craving |
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Term
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Definition
thirst, muscle weakness, lethargy, depression
later: muscle cramping, vomiting |
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Term
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Definition
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Term
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Definition
dysuria, hematuria, urgency, frequency, hesitancy, suprapubic pain, cloudy urine |
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Term
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Definition
UTI anti-infective
newer drug, broad spectrum with greater effects on gram-neg bacteria
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Term
sulfamethoxazole/trimethoprim (Bactrim DS) |
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Definition
older drug, sulfa based, BID dosing |
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Term
nitrofurantoin (Furadantin) |
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Definition
older drug, short t1/2, not effective against gram-neg bacteria |
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Term
phenazopyridine (Pyridium) |
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Definition
Urinary tract analgesic
Action: direct topical anesthesia on urinary tract mucosa
ADME: widely used, very rapid
SE: turns urine reddish-orange, potential liver/kidney toxicity so only use for 2 days |
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Term
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Definition
Antispasmodics
Indications: muscle spasms along with urinary tract
Action: relaxes smooth muscle in bladder
SE: urinary hesitancy |
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Term
tolterodine (Detrol, Detrol LA) |
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Definition
Antispasmodic
Indication: overactive bladder
Action: muscarinic receptor antagonist, inhibition of bladder contractions
SE: constipation, dyspepsia |
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Term
pentosan polysulfate sodium |
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Definition
bladder protectanct
indication: relief of bladder pain assiciated with interstitial cystitis
Action: adheres to bladder wall and acts as a buffer
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Term
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Definition
Drug to treat BPH
Indications: relief symptoms of BPH, also used with HTN
Action: Alpha 1 selective blocker
SE: HA, fatigue, postural hypotension, tachycardia, hypotension, GI sx, decreased libido |
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Term
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Definition
Drug to treat BPH
Indication: long term to shrink prostate
Action: inhibits cellular enzyme the prostate is dependent on for development and maintenance
SE: decreased libido, ED |
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Term
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Definition
Drug to treat BPH
Indication: manage outflow obstruction from BPH
Action: decreases smoth muscle cntractions of prostate
ADME: 94-99% protein bound
SE: dizziness, HA, orthostatic hypotension |
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Term
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Definition
inflammation of the prostate, cmmon in older men, thought to be associated with relux of infected urine, STI, most often gram-neg organism
S/S: sudden onset fever, urinary symptoms, bacteriuria
Digital exam: swollen prostate, warm, tender, purulent discharge
Tx: same as UTI |
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Term
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Definition
upper tract infection, kidney
Sx: high-grade fever, severe flank pain in addition to lower tract symptoms
Tx: outpatient for uncomplicated cases, 2wks of abx, inpatient if severe signs, bacterim or fluoroquinolone for gram-neg, amoxicillin for gram-pos, may require combo IV antibiotics |
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Term
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Definition
hematuria, pus, cellular casts |
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Term
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Definition
Proteinuria, edema, hypoproteinemia (esp. albumin), hyperlipidemia, hypercoagulability |
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Term
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Definition
Most common is strep throat, Other immune disorder, HTN, DM, viruses, endocarditis
Sx: tea-colored urine, foamy urine (due to protein), sweling of face and distal extremities, less frequent urination
Tx: mediation of inflammatory process, loop diuretic, ACEI, lipd-lowering agent anticoagulant, dialysis |
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Term
Nephrolithiasis - Kidney stones |
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Definition
Most common type is calcium oxalate crystals, formed in kidney, can later migrate into ureter (natural occurrence or drug induced)
Sx: may be asymptomatic, dull flank pain, excruciating pain, hematuria
Tx: analgesia, strain all urine for stone for lab analysis, lithotripsy |
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Term
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Definition
monitor intake/output - note amount, color, clarity, odor
dietary and fluid management
restrict Na, water, potassium, phosphate, excess protein when appropriate
daily weight
emotional support
dialysis preparation when fluid overload, hyperkalemia, acidosis, GFR<10ml.min
education |
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Term
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Definition
Major endocrine hormones: ADH, oxytocin, FSH, LH, TSH, ACTH |
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Term
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Definition
Major endocrine hormones:T3, T4, calcitonin |
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Term
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Definition
Major endocrine hormones: insulin, glucagon |
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Term
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Definition
Major endocrine hormones: Gluco- and mineral corticoids, androgen |
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Term
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Definition
Action: stimulates steroid release from adrenals
Indications: antiinflammatory properties, test the functioning of adrenal
SE: water and sodium retention, hypokalemia, myalgia |
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Term
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Definition
Action: stimulates anabolic processes
Indication: children with growth failure
SE: antibodies to GH, insulin resistance, joint pain, HA
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Term
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Definition
Action: dopamine agonist that inhibits GH (acromegaly), opposite effect in normal people
Indication: acromegaly for people >15yrs old
SE: dizziness, HA, N/V, constipation, nasal congestion, diarrhea, fatigue |
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Term
desmopression acetate (DDVAP) |
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Definition
Action: synthetic vasopressin (ADH) analog, enables kidneys to concentrate urine, also stop bleeding in hemophilia A
Indications: diabetes insipidus, nocturnal enuresis
SE: HTN, flushing, water retention, rhinitis, nausea
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Term
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Definition
Enlarged gland due to iodine deficiency, low levels of T3&T4 to increase TSH causing hypertrophy and hyperplasia |
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Term
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Definition
T3 & T4 low, TSH high, severe state is called myxedema |
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Term
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Definition
T3 & T4 high, TSH low, severe state is called thyrotoxicosis |
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Term
levothyroxine (Synthroid, Levoxyl) |
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Definition
Action: replaces T4
ADME: well absorbed, 50-75%
SE: dose related, most common cardiac dysrhythmias
Drug-drug: decreases effect of beta blockers, digoxin, and theophyline, increases effects of warfarin
Education: life long therapy needed, labs to guide |
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Term
iodine products (SSKI or saturated solution of potassium iodide) |
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Definition
Indication: hyperthyroidism
Action: interfers with release of T3 and T4
ADME: slowly absorbed and about a third stored
SE: sore gums, swelling of salivary glands, metalic taste
Caution: harmful with pregnancy, new born goiter
Education: bad taste, evaporates quickly, discolors teeth |
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Term
propylthiouracil (Propyl-Thyracil or PTU) |
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Definition
Action: inhibits incorporation of iodine into tyrosine and conversion of T4 to T3 in tissues
ADME: peak effects 17 weeks
SE: loss of taste, pruritus, fever, smokey-colored urine, muscle and joint ache
Caution: pregnancy D, may cause permanent hypothyroidism in fetus
Education: evenly spaced doses, same time every day with meals, report fever, sore throat, rash, no OC foods containing iodine |
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Term
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Definition
Antihypocalcemic agents
Action: with vit. D regulates absorption of calcium and phosphate
ADME: well absorbed and stored in fat, liver, muscle, skin, bones. Excreted in bile
SE: weakness, muscle and bone pain, metalic taste |
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Term
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Definition
Antihypercalcemic agent
Action: blocks bone reabsorption thus lowering calcium levels, no effects on new bone growth
ADME: slow onset and long duration
SE: bone pain, must stand or sit for atleast 30minutes after dose because it can cause esophageal erosion
Caution: must be taken with a full glass of water before eating |
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Term
calcitonin salmon (Fortical) |
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Definition
Antihypercalcemic agent, postmenopausal osteoporosis
Action: inhibits bone resorption, increases increase excretion of phosphate, calcium, and sodium
SE: flushing, n/v, nasal irritation if spray is used |
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Term
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Definition
ADME: affected by circulation, formulation and route also affect absorption, usually given subcut, but can be given on pump, IV for emergency, intra-abdominal sites prefered, 1 mL syringes and small needles used, dosage given usually based off a sliding scale, look at consistency, not all insulins can be mixed
Drug-drug interactions: beta blockers inhibit insulin release, ETOH increases bg levels, ASA increases baseline insulin levels
Hgb A1C - marker for hyperglycemic serum levels and diabetes control
SE: hypoglycemia (hunger, weakness, diaphoresis, nervousness, tremor, tachycardia, HA, blurred vision, disorientation, coma) |
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Term
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Definition
diet, exercise, weight control, check bg levels, cost of supplies, interaction with ETOH, marijuana, cigarettes, CNS drugs, insulin storage, mixing, administration, emergency treatment |
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Term
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Definition
First generation: tolbutamide (Orinase)
Second generation: glyburide (Micronase)
Action: enhances releance of insulin from beta cells, decreases liver glycogen breakdown, increases cell sensitivity to insulin
ADME: well absorbed, oral, attaches to protien
SE: GI sx, anorexia, muscle cramps, edema of the face, weakness, confusion
Drug-drug: adrenergics, steroids, thiazides, thyroid meds decrease hypoglycemic effects, ETOH has antabuse reaction, oral anticoagulants |
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Term
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Definition
Meglitinides
Action: stimulation of beta cells in pancreas
SE: similar to sulfonylureas |
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Term
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Definition
Biguanides
Action: decreases glucose absorption from intestine, increases insulin sensitivity, does not stimulate beta cells
SE: GI sx, HA |
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Term
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Definition
Alpha-glucosidase inhibitors
Action: delay absorption and digestion of carbohydrates
ADME: poorly absorbed
SE GI sx |
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Term
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Definition
pioglitazone (Actose), and rosiglitazone (Avandia)
Action: resensitizes the body to insulin, activates receptors that control producation, transport and use
SE: HA, edema, myalgia, sinusitis, URIs, wt gain
Caution: monitor LFTs q2mo for a year |
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Term
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Definition
Hyperglycemic agent
Severe hypoglycemia, raises bg, provides 4kcal/gm,
well absorbed and rapid response |
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Term
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Definition
Hyperglycemic agent
when oral glucose can not be used, t1/2 10minutes
Acts on the liver to stimulate glycogen breakdown to glucose to increase blood levels
Parenteral use only |
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Term
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Definition
cortisone (Cortone), prednisone (Deltasone), and dexamethasone (Decadron)
ADME: absorbed well all routes except rectal
SE: increased appetite, insomnia, restlessness, anxiety, low BP, HA, hirsutism, low resistance to infection, increased thirst and urination, Na and water retention, muscle wasting, decreased growth in children
Caution: weight gain, round face (cushings)
drug-drug: antacids, vit k, oral hypoglycemics, dig, diuretics, vaccines |
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Term
Glucocorticoids implications
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Definition
Daily weight, occult blood in stool, monitor blood glucose levels, single dose am with food, Na restrictions and K supplement, weight-bearing exercises to decrease risk of osteoporosis, withdrawal must be gradual (the longer the therapy the more likely to have side effects) |
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Term
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Definition
Aldosterone, stimulates reabsorption of Na and keeps K in balance, use for Addison's disease (hypoaldosteronism), |
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Term
fludrocortisone (Florinef) |
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Definition
Mineralcorticoids
ADME: well absorbed
SE: HA, HTN, dizziness, edema of lower extremities, joint pain, hypokalemia, weakness, paresthesias in legs, CHF
Contraindication: HTN, CHF, renal disease, heart disease
Nursing considerations: weight gain, monitor I&O, BP, Na restrictions, monitor electrolytes (especially K) |
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Term
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Definition
Action: affects the release of FSH and LH, conserves Ca Phos for bone formation, inhibits ovulation
Indication: menopausal sx, prostate cancer, inoperable breast cancer, female hypogonadism |
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Term
conjugated estrogen (Premarin) |
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Definition
Action: increases synthesis of DNA, RNA, and protein in estrogen sensitive tissues, NA and water retention, lowers cholesterol
Indication: estrogen deficiency w/ vasomotor sx, osteoporosis prevention, urinary meatus/vaginal atrophy |
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Term
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Definition
SE: stomach cramps or gas, anorexia, HA, n/v, decreased libido, edema in LE, breast pain and enlargement, changes in menstrual bleeding, wt gain
Caution: risk of endrometrial Ca with prolonged use, not given when pregnant or breast feeding, baseline labs before therapy
Contraindications: breast cancer, abnormal vaginal bleeding
Increased risk of MI, pulmonary embolism, DVT, Thrombophlebitis |
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Term
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Definition
Prepares uterine lining for egg implantation, decreases target organ response to estrogen, stimulates thyroid, blocks aldosterone receptors, binds to GABA receptors, decreases anxiety |
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Term
progestin (various formulations) |
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Definition
Action: diminish endometrial tissue proliferation, thicken vaginal mucosa, neg feedback to release FSH an LH, relax uterine smooth muscle, increase appetite
Indication: uterine bleeding due to hormonal imbalance, fibroids, or uterine cancer, combined with estrogen to lower risk of endometrial Ca, to prevent pregnancy
SE: liver dysfunction, thrombophlebitis, and DVT, breakthrough bleeding/spoting, breast tenderness, GI upset, wt gain, rash and depression
Contrandications: pregnancy, idiopathic vaginal bleeding, breast and genital cancer, hx of thromboembolism, hepatic dysfunction, STI/PID or pelvic surgery |
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Term
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Definition
Hydroxyprogesterone (Hylutin), Medroxyprogesterone (Depo-provera), Progesterone (Progestasert) |
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Term
Low dose oral contraceptives |
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Definition
Lower risk for adverse CV effects, decreased risk for ectopic pregnancy, increased risk for MI, increased risk for cervical, liver, and earlier onset of breast cancer, increased risk for gallbladder disease.
Action: inhibit secretions of FSH and LH, changes in endometrum that impair ova implantation, increased vaginal mucus viscosity to impede passage of sperm
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Term
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Definition
weight gain, stomach cramps, swelling of face and lower extremities, HA, mood alterations, Gall stones, increased clotting, amenorrhea, breakthrough bleeding, menorrhagia, acne, insomnia, breast pain, increased risk of STD, hyperglycemia |
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Term
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Definition
protection against pregnancy, ovarian cyst suppression, iron deficiency anemia resolution, reduced rheumatoid arthritis, higher bone density |
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Term
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Definition
allergy to a specific product, higher risk for thromboembolitic events
Interactions: reduced effect if taken with antibiotics, barbiturates, griseiofluvin, INH. decreased effect of anticonvulsants, beta-blockers, hypoglycemic drugs, anticoagulants, theophylline, TCAs, vitamins |
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Term
types of combined estrogen and progestin |
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Definition
Monophasic - fixed ratio, biphasic - fixed estrogen with various amounts of progestin, triphasic - variable, estrostep - graduated estrophasic dosage |
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Term
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Definition
Fixed combinatin, inserted into vagina and left for 3weeks and removed for 1week |
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Term
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Definition
Fixed combo, worn as a transdermal patch aplied weekly for 3weeks and then removed for 1 week |
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Term
Preogesterone contaceptive |
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Definition
Low dose mini pill (Ovrette) that does not contain any estrogen, good for smokers, older females, breastfeeding women, avoids estrogen SE
Long lasting depo-provera (IM injection), progestasert (IUD)
SE: no menstrual periods, vaginal bleeding, muscle pain, GI distress, wt gain, vaginitis, breast discharge |
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Term
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Definition
higher dose of contraceptives, 2 tablets that can be taken together or taken 12 hours apart, must initiate within 72 hours of having unprotected sex, now available w/o rx but must be 17 yr old to purchase, is NOT abortifacient |
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Term
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Definition
Progesterone antagonist, administered with misoprostol to stimulate uterine contractions, cannot be used in tubal pregnancy, bleeding can be severe and require transfusion |
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Term
clomiphene citrate (Clomid) |
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Definition
Action: unknown, thought to compete in hypothalamus for estrogen receptor sites to stimulate the release of FSH and LH
ADME: given for 5 days starting on day 5 of cycle, can be taken 3-4 times, if ovulation does not occur then increase dosage for another 5 days
SE: hot flashes, HA, breast tenderness, n/v, insomnia, blurred vision, floaters, photophobia, enlargement of ovarian cysts
Monitor ovarian size before the beginning of each dose, HCG if menses does not occur before next tx, urine LH to predicit ovulation, should take at the same time every day, coitus around time of ovulation, possibility of multiple births |
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Term
Uterine relaxants (Tocolytics) |
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Definition
Ritodrine (Yutopar) and Terbutaline (Brethine)
Indication: halt premature labor
Action: beta 2 stimulation relaxes the myometrium, IV produces effects in 5 minutes
SE: Anxiety, n/v, HA, tachycardia, reactive hypoglycemia in newborn |
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Term
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Definition
Indication: induce or augment labor, decrease post partum bleeding via muscle contraction
Action: raises Ca in uterine muscle increasing contraction if labor started
SE: hypotension, uterine rupture, induced stroke during labor, abruption placenta |
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Term
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Definition
Alendronate (Fosamax) and Ibandronate (Boniva)
inhibit bone reabsorption which enhances bone mineral density
SE: HA, GI sx, joint pain, risk of esophageal burn if they become lodged in esophagus
Contraindication: hypocalcemia, esophageal dysfunction, inabilty to sit or stand for 30 minutes after taking |
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Term
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Definition
Stimulates estrogen receptors on bone and increases bone density |
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Term
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Definition
Only drug available that stimulates bone formation
SE: chest pain, dizziness, hypercalcemia, nausea, arthralgia |
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Term
Caution for testosterone therapy |
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Definition
Causes fluid retention and hypercholesterolemia, use carefully in patients with cardiac impairment or renal disease, significant interaction with anticoagulants, may cause prostate enlargement and worsen BPH, worsens hypercalcemia secondary to metastatic breast Ca |
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Term
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Definition
inhibits bone reabsorption
SE: facial flushing, nausea, anorexia |
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Term
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Definition
SE: increased risk of thromboembolism, teratogenic, leukopenia
Contraindication: women who are pregnant or may become pregnant, thromboembolic disorders |
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Term
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Definition
Naturally occuring anabolic steroid
Indication: delayed male puberty, tx of breast cancer and anemia, use for wt gain, muscle building, and strength, androgen deficiency and hypogonadism
SE: abd pain, insomnia, n/v/d, depression, red skin, HA, pruritus, jaundice, change in libido. SE in females: ance, deepening voice, increased hair growth or alopecia, enlarged clitoris, irregular menses. SE in males: urinary urgency, gynecomastia, frequent erection |
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Term
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Definition
Get a baseline ht, wt, and sexual development in children and bone age determination q6mo, monitor serum Ca, cholesterol levels, LFTs, H&H for polycythemia, monitor tumor growth, monitor signs of BPH in older men
Contraindication: androgen-responsive tumors, severe hepatic, cardiac, or renal disease |
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Term
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Definition
Action: inhibits an enzyme that converts testosterone into potent androgen DHT by 70% which causes shrinkage in prostate, lower dose used for baldness
SE: decreased libido, impotency, decreased amount of ejaculate
Pregnant women should not handle unless wearing gloves |
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Term
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Definition
Prazosin (Minipress) and Terazosin (Hytrin)
nonselective alpha adrenergic blockers to decrease contractility of smooth muscle in bladder and urethra |
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Term
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Definition
Cantharis (Spanish fly), Yohimbine, Opoids (morphine, heroin, cocaine, marijuana, LSD), Amyl nitrite, Alprostadil (prostaglandin) injectable into corpus cavernosus |
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Term
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Definition
Action: increases levels cyclic guanosine monophosphate (cGMP), a smooth muscle relaxant, results in inflow of blood and an erection
Indications: erectile dysfunction
Administration: 1hr before sexual activity, not with high fat meal may cause delayed response
SE: HA, nausea, GI distress, facial flushing, nasal congestion, back pain, flu syndrome, arthralgia, allergic reaction, cardiovascular sx, visual changes
Contraindication: concomitant use of organic nitrate (nitroglycerin and nitroprusside)
Teaching: increase fluid intake to prevent UTI, seek tx if CV sx |
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