Shared Flashcard Set

Details

Exam 4
peptic acid disease, laxative, prokinetics, antidiarretics, IBS, IBD, opioids, NSAIDS, antiarthritics, immunosuppressives, immunomodulatory
80
Pharmacology
Graduate
10/19/2014

Additional Pharmacology Flashcards

 


 

Cards

Term
calcium carbonate (Tums)
Definition
Neutralizes acid (heartburn, gastritis, peptic ulcer disease)
Term
aluminum hydroxide/magnesium hydroxide (Maalox)
Definition
Neutralizes acid (heartburn, gastritis, peptic ulcer disease)
Term
cimetidine
Definition
competitive antagonist of H2 receptors on parietal cells (GERD, peptic ulcer disease)
Term
ranitidine
Definition
competitive antagonist of H2 receptors on parietal cells (GERD, peptic ulcer disease)
Term
omeprazole
Definition
proton pump inhibitor--irreversibly inactivates H+/K+ ATPase (GERD, peptic ulcer disease, gastrinomas including zollinger-ellison syndrome)
Term
sucralfate
Definition
aluminum salt of sulfated sucrose--forms protective barrier
Term
misoprostol
Definition
PGE1 analogue (prevent NSAID induced ulceration)
Term
bismuth subsalicylate (pepto bismol)
Definition
coats stomach, antibacterial activity, antidiurrhetic
Term
dietary fiber (Psyllium--metamucil)
Definition
bulk forming laxative, antidiurrhetic
Term
methylcellulose (citrucel)
Definition
bulk forming laxative, antidiurrhetic
Term
polycarbophil (FiberCon)
Definition
bulk forming laxative, antidiurrhetic
Term
docusate (colace)
Definition
stool surfactant agent--detergent
Term
magnesium hydroxide (milk of magnesia)
Definition
osmotic laxative
Term
polyethylene glycol
Definition
osmotic laxative (colonic cleansing prior to diagnostic and surgical procedures)
Term
bisacodyl (dulcolax)
Definition
stimulant laxative (acute and chronic constipation, colonic cleansing with PEG prior to procedures)
Term
anthraquinone derivatives (Senna--SennaKot)
Definition
stimulant laxative (ex lax)
Term
metoclopramide (reglan)
Definition
prokinetic agent--dopamine D2 receptor antagonist and partial 5-HT agonist (gastroparesis, reflux esophagitis, antiemetic)
Term
erythromycin
Definition
antimicrobial--stimulates motilin (diabetic gastroparesis, gastric emptying of blood from upper GI hemorage prior to endoscopy)
Term
methylnaltrexone
Definition
selective intestinal opioid receptor antagonist (opioid induced constipation, postoperative ileus)
Term
alvimopan (entereg)
Definition
selective intestinal opioid receptor antagonist (postoperative ileus)
Term
loperamide
Definition
opioid, (antidiurrhetic)
Term
dicyclomine
Definition
anticholinergic antispasmodic (IBS)
Term
hyoscyamine
Definition
anticholinergic antispasmodic (IBS)
Term
lubiprostone
Definition
chloride channel activator (constipation, IBS in females)
Term
sulfasalazine (azulfidine)
Definition
topical aminosalicylate, immunosuppresive (IBD, RA-non biological DMARD)
Term
mesalamine (apriso)
Definition
topical aminosalicylate, COX1/COX2 inhibitor (IBD)
Term
budesonide (entocort)
Definition
glucocorticoid (acute attacks of IBD)
Term
azothiaprine (imuran)
Definition
antimetabolite, signal 3 inhibitor of mainly T cells (chronic severe or steroid-resistant IBD, RA, renal transplant)
Term
methotrexate (trexall, rheumatrex, folex)
Definition
antimetabolite--dihydrofolate reductase inhibitor, signal 3 inhibitor both B and T cells (chronic severe or steroid-resistant IBD, RA-nonbiologic DMARD, leukemia, tumors)
Term
infliximab
Definition
monoclonal antibody against TNF alpha (Crohn's, RA-biologic DMARD)
Term
natalizumab
Definition
anti-integrin (Crohn's)
Term
simethicone
Definition
antiflatulent
Term
morphine
Definition
mu opioid agonist (severe pain)
Term
hydromorphone (dilaudid, palladone)
Definition
mu opioid agonist (severe pain)
Term
codeine
Definition
opioid, mild-moderate pain, antitussive
Term
oxycodone (roxicodone, percodan, oxycontin)
Definition
opioid, moderate-severe pain, oxycontin for severe chronic pain
Term
hydrocodone (lortab, lorcet, vicodin, norco)
Definition
opioid, mild-moderate pain, antitussive
Term
meperidine (demerol)
Definition
opioid, moderate-severe pain
Term
heroin (diacetylmorphine)
Definition
opioid,more potent and euphoric than morphine
Term
methadone (dolophine)
Definition
opioid, analgesic and treatment for opioid addiction
Term
fentanyl (sublimaze, duragesic, innovar)
Definition
opioid, very potent mu agonist (surgical anesthesia, transdermal prep for chronic pain, lozenge for breakthrough pain)
Term
pentazocine (talwin)
Definition
opioid, kappa agonist, partial mu agonist (severe pain)
Term
butorphanol (stadol)
Definition
opioid, kappa agonist, partial mu agonist (severe pain)
Term
buprenorphine (buprenex, subutrex, suboxone)
Definition
opioid, partial mu agonist (office based opioid addiction)
Term
tramadol (ultram)
Definition
opioid, weak mu agonist, inhibits reuptake of NE and serotonin (mild-moderate pain)
Term
tapentadol (nucynta)
Definition
opioid, partial mu agonist, inhibits reuptake of NE and serotonin (moderate-severe pain)
Term
naloxone (narcan)
Definition
opioid antagonist (opioid poisoning)
Term
naltrexone (ReVia)
Definition
long acting opioid antagonist ("immunizing" addicts, alcoholism)
Term
acetyl salicylic acid (aspirin)
Definition
irreversibly inhibits COX1 and COX2 (analgesic, antipyretic, antiinflammatory, antirheumatic)
Term
diflusinal
Definition
COX1/COX2 inhibitor (analgesic, antiinflammatory, weak antipyretic)
Term
indomethacin (indocin)
Definition
COX1/COX2 inhibitor (rheumatoid arthritis, osteoarthritis, tocolytic--suppresses premature labor)
Term
etodolac
Definition
COX1 and BIG COX2 inhibitor (rheumatoid/osteoarthritis, postoperative analgesia)
Term
diclofenac (voltaren)
Definition
COX1/COX2 inhibitor (rheumatoid/osteoarthritis, analgesia/dysmenorrhea)
Term
tolmetin
Definition
COX1/COX2 inhibitor (rheumatoid/osteoarthritis, juvenile RA)
Term
ketorolac
Definition
COX1/COX2 inhibitor (moderately severe acute pain, NOT for OA or RA)
Term
ibuprofen (motrin)
Definition
COX1/COX2 inhibitor (RA, OA, analgesia, dysmenorrhea, fever)
Term
naproxen (anaprox, aleve)
Definition
COX1/COX2 inhibitor (RA, juvenile RA, OA, analgesia, dysmenorrhea)
Term
ketoprofen
Definition
COX1/COX2 inhibitor (RA, OA, analgesia, dysmenorrhea)
Term
oxaprozin (daypro)
Definition
COX1/COX2 inhibitor (RA, OA)
Term
piroxicam (feldene)
Definition
COX1/COX2 inhibitor (RA, OA)
Term
meloxicam (mobic)
Definition
COX1/more COX2 inhibitor (OA)
Term
nabumetone
Definition
COX1/more COX2 inhibitor (RA,OA)
Term
celecoxib (celebrex)
Definition
COX2 inhibitor (RA, OA, dysmenorrhea, acute pain, familial adenomatous polyposis)
Term
acetaminophen (tylenol)
Definition
analgesia from weak COX1/COX2 inhibition and COX3 inhibition in CNS, antipyresis by action on hypothalamic heat-regulating center (antipyretic, analgesic, OA)
Term
hydroxychloroquine sulfate (plaquenil)
Definition
non biologic DMARD (RA, lupus, antimalarial)
Term
leflunomide (arava)
Definition
non biologic DMARD, dihydroorotate dehydrogenase inhibitor--inhibits pyrimidine synth. (RA)
Term
etanercept (enbrel)
Definition
biologic DMARD--anti TNF alpha and beta (RA, Juvenile RA)
Term
anakinra (kineret)
Definition
biologic DMARD--IL-1 receptor antagonist (RA)
Term
prednisone (intensol)
Definition
glucocorticoid-inhibits phospholipase A2 and COX2 (allergies, hematologic disorders, hepatic/renal disease, collagen disorders)
Term
methyprednisolone (medrol)
Definition
glucocorticoid-inhibits phospholipase A2 and COX2 (allergies, hematologic disorders, hepatic/renal disease, collagen disorders)
Term
cyclophosphamide
Definition
signal 3 inhibitor, inhibits B and T cells (RA, leukemia, tumors)
Term
mycophenolate mofetil (cellcept)
Definition
signal 3 inhibitor of B and T cells-inhibits purine synthesis (renal/liver/heart transplant rejection)
Term
cyclosporine (sandimmune)
Definition
signal 1 inhibitor of T cells-calcineurin phosphatase inhibitor (renal/liver/heart transplant rejection, RA)
Term
muromonab-CD3 (orthoclone OKT3)
Definition
murine Ig-signal 1 inhibitor of T cells-CD3 receptor antagonist (renal/liver/pancreas/heart transplant rejection)
Term
lymphocyte immune globulin (atgam)
Definition
horse Ig-T cell suppression (renal transplant rejection)
Term
daclizumab (zenapax)
Definition
human IgG1-signal 3 inhibitor-IL-2 receptor antagonist (renal transplant rejection)
Term
Rho immune globulin (RhoGam)
Definition
human Ig (erythroblastosis fetalis)
Term
immune globulin (gammagard)
Definition
human IgG, IgM (hypogammaglobulinemia, prophylaxis in HIV patients)
Term
interferon beta-1b (betaseron)
Definition
antiviral/immunoregulator (relapsing-remitting multiple sclerosis)
Term
interferon gamma-1b (actimmune)
Definition
phagocyte activator, antibody-dependent cellular cytotoxicity (chronic granulomatous disease)
Supporting users have an ad free experience!