Term
| aqeuous humor flow through the |
|
Definition
|
|
Term
| 15% of aqeous humor leaves eye thru |
|
Definition
|
|
Term
| this recpotr increase aqeous humor production |
|
Definition
|
|
Term
| this recpto blocks outflow of aqeous humor |
|
Definition
|
|
Term
| alpha 1 or 2 can block further release of NE |
|
Definition
|
|
Term
| sympatheic system is respon for- |
|
Definition
|
|
Term
| muscarinic AcH recpt leads to-4 |
|
Definition
contraction of ciliary muscle
increase of trabecular flow
miosis (pupil contraciton)
-increase uveoscleral outflow |
|
|
Term
| blockage of cillialry epithelium leads to- |
|
Definition
| reduced secretion and reduced IOP |
|
|
Term
| contraction of ciliary muscle leads to |
|
Definition
| contraction by muscairnic cholinomimets-> reduced IOP |
|
|
Term
|
Definition
increase ocular bioavail
reduce systemic absorption |
|
|
Term
|
Definition
|
|
Term
|
Definition
reduce aqueas humor secretion
enhance aqeous outflow |
|
|
Term
| agetns fro galucoma incerase- |
|
Definition
| trabecular and uveoscelral outflows |
|
|
Term
| agents for galucoma decrease |
|
Definition
|
|
Term
| MOA of b blockers for galucoma |
|
Definition
| decrease aqeous flow by blocking B2 |
|
|
Term
| beta blockerds cna be topical |
|
Definition
|
|
Term
| non selective b blockers for glaucoma |
|
Definition
timolol
levbunolol
metipranolol
carteolol |
|
|
Term
| the selective b1 blocker for glaucoma |
|
Definition
|
|
Term
| local side effects of B blockers-2 |
|
Definition
|
|
Term
| ssytimc ADES of beta blockers-2 |
|
Definition
|
|
Term
| whihc ebta blockers have lower risk of bronchospasm and cardi effects-2 |
|
Definition
|
|
Term
| to minimze systmic effects of beta blockers do what |
|
Definition
|
|
Term
| b blockers are contraindcated in-7 |
|
Definition
lung dis
sinus bradycard
diabetes
HF
heart block
athersclerosis
therapy of oral beta blcoker |
|
|
Term
|
Definition
| decrease aqeous humor production rate |
|
|
Term
| blocking alpha 2 is like blocking beta 2 post synap |
|
Definition
|
|
Term
| systemic side effects of alpha 2 agonists |
|
Definition
|
|
Term
| what are the akpha 2 agonists |
|
Definition
|
|
Term
|
Definition
|
|
Term
| brimonidine decrease _ and increases _ |
|
Definition
aqeous produciton
uveoscerlal outflow |
|
|
Term
| what is the first line alpha agoinst |
|
Definition
|
|
Term
| MOA of prostoglandin F2 analogs |
|
Definition
| increase uveoscleral outflow by 25%! |
|
|
Term
| which drug class has really good efficacy and side effect profil? |
|
Definition
|
|
Term
| local side effects of F2 analogs |
|
Definition
| irreversible iris pigmentation |
|
|
Term
|
Definition
lantoprost
travoprost
bimatoprost |
|
|
Term
| what are the 1st line tx fr galucoma |
|
Definition
| F2 agoinsts (took over for b blockers) |
|
|
Term
| MOA of carbonic anhyrase inhibitors |
|
Definition
| decrease cililary body aqeous humor secretion (blocks Na and bicarb) |
|
|
Term
| topical carbonic anhydrase inhibitors |
|
Definition
|
|
Term
systemic carboinc inhibitors, whjcih formulaitn are last line drugs
why? |
|
Definition
systemic
systemic acidosis
mult drug interaction (AED, anti HTN |
|
|
Term
| what are the systmic carboinc inhib-2 |
|
Definition
acetazolamide
methazolamide |
|
|
Term
| dont usesystmic and topical carboinc inhiitors togehter |
|
Definition
|
|
Term
| MOA of cholinergic agents |
|
Definition
| increase aqeous trabecular outflow-> reduce IOP |
|
|
Term
| what are the cholinergic agents-3 |
|
Definition
pilocarpine
carbachol
chol inhibit |
|
|
Term
pilocarpine local side effects:
systemic |
|
Definition
miois, spasm
diarrhea, n.v |
|
|
Term
|
Definition
| more freq an dsevere than pilocarpine |
|
|
Term
| cholinesterase inhbiitors are limited use bc |
|
Definition
|
|
Term
| what are hte cholinesterase inhibitors-2 |
|
Definition
|
|
Term
| non specific adrenergic agonists MOA |
|
Definition
| increase tubc an duvsceleor outflow |
|
|
Term
| non specf adreng agonist- |
|
Definition
|
|
Term
| what is the ester prodrug of epi:? |
|
Definition
|
|
Term
| whihc is the adjunct drug |
|
Definition
|
|
Term
| local side effects of dipivefin:2 |
|
Definition
|
|
Term
| systemic side effects of dipivefrin:3 |
|
Definition
| BP, tachycardia, headache |
|
|
Term
| which drug can cause adrenochrome (depost pigment into conjuctiva na dcornea) |
|
Definition
|
|
Term
| * can lead to trainset increase in IOP-> acute angle closure galucomea |
|
Definition
|
|
Term
| look on slide 22 right befoer test for quick over view of all drugs |
|
Definition
|
|
Term
medicaiton for closed angle galucoma-4
*thse all used BEFORE surgery to reduce pressure |
|
Definition
secretory inhbiitors
hyperosmotoc agent
topical corticosterois
pilocarpine |
|
|
Term
| most common cause of blindness in elderly |
|
Definition
|
|
Term
| *dry form mac deg dont have vision loss; |
|
Definition
|
|
Term
| which is more the dry or wet form of mac deg |
|
Definition
|
|
Term
|
Definition
|
|
Term
| non pharm tx for mac deg-3 |
|
Definition
quit smoking
photodynamic therapy (lasers)
trnaslocaiton surgery |
|
|
Term
| angiogensis in wet mac deg is driven by |
|
Definition
|
|
Term
therapy for wet mac deg
examples: |
|
Definition
VEGF anatags
ranbizumab
pegatanib
bvacizumab |
|
|
Term
| side effects of VEGF antagonists-3 |
|
Definition
eye hemorrhage
immune resp
intraocular inflamm |
|
|
Term
| antioxidants used for mac deg; vitamins:5 |
|
Definition
| C, E, zinc, copper, carotene |
|
|
Term
| other anti oxidants fro mac deg |
|
Definition
|
|
Term
| *cataracts= dead cells accum in lens capsule and make it clouded and yellow |
|
Definition
|
|
Term
|
Definition
| mydriatics, anesthetics, ABX |
|
|
Term
|
Definition
| ABX, anti inflamm, corticosteroids |
|
|
Term
| Post surgery anti infalmm agents-2 |
|
Definition
NSAIDS (ketorolac, diclofenac)
coritcosteroids (prednisolone) |
|
|
Term
| post surgery cataracts ABX:2 |
|
Definition
fluroquinolone
aminoglucosides |
|
|
Term
| Tobradex= dexmethasone and tobramysone for catract post srugery |
|
Definition
|
|
Term
| dry eye= evaporative or tear deficit |
|
Definition
|
|
Term
| aritfical tears use what soln |
|
Definition
|
|
Term
| opthalmic lubricants for dry eye are |
|
Definition
|
|
Term
| opthalmic inserts for dry eye= |
|
Definition
|
|
Term
dry eye secretagogues:2
MOA? |
|
Definition
pilocarpine
cevimelin
M3 agonists |
|
|
Term
|
Definition
|
|
