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Exam 4
Lecture 14- MS treatment
47
Architecture
9th Grade
12/12/2013

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Term
when do acute exacerbations not need to be treated?
Definition
when dont result in function decline
Term
if treating for acut excaerbation what d you give
Definition
methylprednisolone 500 mg IV x 3 days
Term
what is the benefit of giving steroid with acute exacerbatin-3
Definition
shorten length of exacerb
delay tiem til next occurance
reduce edema
Term
what are first line theapies for disease modifying-3
Definition
interferon B1b and interferon B1a and glatiramer acetate
Term
pros of interferons-2
Definition
reduce annual replase rates and MRI burden
slow brain atrophy and cogntivie decline
Term
MOA of interferons-3
Definition
reduce interferon secrection by lymphocytes
suppress T cell and BBB permeability
increase CD56 antural killer cells and Treg cells
Term
ADEs of interferons-5
Definition
elevated LFTs
decrease CBC
injection site
depression
thyroid
Term
monitoring for interferons-3
Definition
CBC 1 mo,q 3 mo, then q6
LEFTs same as above
neutralizing antibody testing
Term
Betaseron
Definition
IFN B1b
Term
dose of IFN B1b
Definition
25 mcg SQ every toher day
Term
dose of IFN B1a (Avonex)
Definition
30 mcg IM qweek
Term
dose of IFN B1a (rebif)
Definition
22 or 44 mcg SQ three times weekly
Term
what is the pearl about IFN B1a meds
Definition
refridge, but can be at room temp for 30 days
Term
Copaxone
Definition
glatirmaer acetate
Term
glatiramer acetate pros
Definition
reduce relapse rate by 30% and releive MRI burdern
Term
which drug may slow progression of relapse/remitting MS?
Definition
glatiramer
Term
which drug cna you use safely for 10 yrs
Definition
glatiramaer
Term
MOA of glatiramer-4
Definition
polypet of L alaline, glut, lysine, tyroinse
mimics myelin basic protein (MBP)
induce T suppressor cell for mylin
induce BDNF for neuroprotection
Term
ADEs of glatiramer-2
Definition
injection site
one time chest tightening/flushing
Term
dosing of glatiramer
Definition
20 mg SQ qd
Term
Tysabri
Definition
natilzumab
Term
pros of natilzumab-3
Definition
reduce CNS lesion by 90%
decrease relapse by 60%
slow progression of disability
Term
MOa of natilzumab-2
Definition
humanized mono antibody
attached very late antigen to block VCAM-1 and decrease lympohcyte entry thru BB
Term
ADEs of natilzumab-3
Definition
injection site
devleop neutralizing antibodies
rare PML
Term
monitoring for natiluzamb
Definition
enrolled in TOUCH
Term
dosing for natiluzumab
Definition
300 mg IV q 4 wks
Term
Gilenya
Definition
fingolimod
Term
which drug decreases relapse by 50%
Definition
fingolimod
Term
MOA of fingolimod-2
Definition
sphingosine 1 phos recpt agonist
requesters lymphocytes into 2nd lymph organs
Term
ADEs of fingolimod-4
Definition
LEFTs
lymphopenia
macular edema
ifx
Term
monitoring for fingolimod-3
Definition
opthamologic exam
ECG
BP
Term
dosing for fingolimod
Definition
.5 mg PO q day
Term
Novantrone
Definition
mitoxantrone
Term
which drug is last line agent
why?
Definition
mitoxantrone
cardiac toxnad leukemia
Term
mitoxantrone is FDA approvedd for-3
Definition
neuro disability in secondary porgressive MS, primary progressive, or woresning relapse
Term
mitoxantone is 15 min IV infusion q 3 months*
Definition
Term
montioring for mitoxantrone-2
Definition
ECG and LVF befoer ea/ infusion
Term
ADEs of mitoxantrone-4
Definition
UTI, resp infx, alopecia, menstrual
Term
which med doesnt ahve FDA approval
Definition
rituximab
Term
tx for spasticity-3
Definition
baclofen
tizandine
gabapentin
Term
tx for bladder sx:3
Definition
antimuscarinic- oxybutyin, trospium
prazosin
Term
tx for tremor-2
Definition
propanolol
primidone
Term
tx for depression
which agents do you watch fro this closely in?
Definition
antidepressents
interferons and natiluzumab
Term
tx for neuropahtic pain
Definition
CBZ, gabapentin
Term
tx for sex dysfunction (only for men)-3
Definition
taldalifil sildenifil, vardenifil
Term
tx fro fatigue-3
Definition
modafinil
amantafine
amphetamines
Term
tx for impaired cognition-2
Definition
stimulants
cholintesterase inhbitiors
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