Term
|
Definition
| Cyclins are a family of proteins that control the progression of cells through the cell cycle by activating cyclin-dependent kinase (Cdk) enzymes.their concentration varies in a cyclical fashion during the cell cycle; they are produced or degraded as needed in order to drive the cell through the different stages of the cell cycle. |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| pol alpha, pol delta, pol epsilon |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Xeroderma pigmentosum, or XP, is an autosomal recessive genetic disorder of DNA repair in which the ability to repair damage caused by ultraviolet (UV) light is deficient.xeroderma pigmentosum is an autosomal recessive genetic defect in which nucleotide excision repair (NER) enzymes are mutated, leading to a reduction in or elimination of Nucleotide Excision Repair. |
|
|
Term
|
Definition
| Apurinic / apyrimidinic endonuclease (Ape1) is responsible for the incision of DNA basic sites during base excision repair. |
|
|
Term
|
Definition
| Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| DNA activated protein kinase. |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| RNase H is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.RNase H’s ribonuclease activity cleaves the 3’-O-P bond of RNA in a DNA/RNA duplex |
|
|
Term
|
Definition
| Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that enables its genetic material to be integrated into the DNA of the infected cell. |
|
|
Term
|
Definition
|
|
Term
|
Definition
| A provirus is a virus genome that has integrated itself into the DNA of a host cell. One kind of virus that can become a provirus is a retrovirus. When a retrovirus invades a cell, the RNA of the retrovirus is reverse-transcribed into DNA by reverse transcriptase, then inserted into the host genome by an integrase. |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Regions of DNA that have lost their nucleosomal character. |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| This is the chromatin remodeling complex that is involved in opening chromatin and making genes more available for transcription. |
|
|
Term
|
Definition
| General term for any protein, other than RNA pol, that is required to initiate or regulate transcription in eukaryotic cells. General factors, required for transcription of all genes, participate in the formation of the pre-initiation complex. Specific factors, like activators or repressors stimulate or inhibit transcription of specific genes by binding to their regulatory sequences. |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
