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Exam 3
Lecture 2- Part 2 (Drugs)
39
Archaeology
6th Grade
10/15/2013

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Term
which drug has michaelis menton kinetics
what does this mean?
Definition
phenytoin
small dose increase= large serum increase
Term
which drugs are highly protein bound (can displace drugs liek coumadin)
Definition
phenytoin, valproic acid
Term
therapetuic level for phenyotin
Definition
10-20
Term
what is equation for corrected phenytoin
Definition
observed conc / (.2 x albumin +.1)
Term
ADEs of phenytoin-4
Definition
neurotoxic
osteopenia
gingival hyperplasia
acne
Term
what are the hepatic inducers (will decrease cl of drugs thru liver)
Definition
phenytoin
Term
what increases Cl of phenytoin
Definition
folate
Term
if phenytoin plasma conc is < _ you increase dose
Definition
12
Term
monitoring for phenytoin
Definition
liver, thryoid, CBC, oral hygiene
Term
what drug does food increase bioavail
Definition
carbamezapine
Term
carbamezapine is metab by
Definition
CYP 3A4
Term
therapeutic level for carbamezapine
-when do you draw dose
Definition
4-14
trough
Term
ADes of carbamezapine
Definition
neurotoxic
osteopenia
agrnaulocytoiss (!!!)
Term
what drug do you disct if wbc<2500 or ANC<1000
Definition
carbamezapine
Term
whihc drug is an autoinducer
what does this mean?
Definition
carbamezapine
conc will decrase during fisrt month
Term
hepatic _ increase Cl of carbamezapine
Definition
inducers
Term
monitoring for Carbamezapine
Definition
CBC, liver, Na
Term
valproic acid is also called
Definition
divalproex
Term
therapeutic level for valproic acid
Definition
50-120
Term
ADEs of valproic acid
Definition
neurotxic
osteopenia
thrombocytopenia, PCOS
Term
valproate does what on hepatic
what drug is the big concern when used with this?
Definition
inhibitor
lamotrigine (will decrease clear)
Term
monitoring for valproic acid
Definition
liver
CBC (platelets)
wt
Term
ADEs of lamotrigine
Definition
life threat hypersensitivity (steven johnson), CNS depression, GI
Term
hepatic _ increase Cl of lamotrigine
Definition
inducers
Term
what drug increases risk of rash when used with lmaotrigine
Definition
valproate
Term
oral contrceptives cna decrease which med
Definition
lamotrigne
Term
monitoring for lamotrigine
Definition
watch for rashes
Term
ADEs of topirmate
Definition
myopia, CNS depression, kidney stones
Term
dont use topiramate with-3
Definition
phenytoin, carbamezapine, carbonic anhydrase inhibitors
Term
monitoring for topiramate
Definition
drink fludis to prevent kid stones, eye exam
Term
ADEs of oxcarbamezapine
Definition
hypoNa and decrease cognition
Term
oxcarbamezapine inhibits _
induces_
Definition
2C19
3A4
Term
monitoring for oxazarbamezapine
Definition
sodium, CNS
Term
ADEs of Keppra
Definition
CNS depression, psychosis, anemia
Term
*** Keppra doesnt interact with CYPs
Definition
Term
monitoring fr Keppra
Definition
CBC
side effects
Term
ADes of zonisamide
Definition
allergy to sulfa, hyperthermia, wt loss
Term
if other drugs act on _, they mess with zonisamide
Definition
3A4
Term
monitoring for zonisamide
Definition
BUN, drink fluids to prevent kid stones
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