Term
all new AEDs are less terotegenic except |
|
Definition
|
|
Term
the new AEDS have what improved things comapred to the 1st gen? -4 |
|
Definition
PK less CYP less EPS less sedation |
|
|
Term
this drug can be used in neonates and older |
|
Definition
|
|
Term
these drugs are approved for children >10 yrs old-2 |
|
Definition
|
|
Term
which drug has risk of liver tox in children <2 |
|
Definition
|
|
Term
this drug can be used for absence seizure with children >2 |
|
Definition
|
|
Term
what are the 2 meds for absence seizures |
|
Definition
|
|
Term
what meds cna be used for lennox gastaut-2 |
|
Definition
|
|
Term
topiramate can be used as monotherapy in what age |
|
Definition
|
|
Term
oxcarbamezapine is adjunst for what age? monotherapy? |
|
Definition
|
|
Term
Levetiracetam shoudl be used in what age |
|
Definition
|
|
Term
which drug isnt approved for use in children |
|
Definition
|
|
Term
factors that imrpove successful AED withdrawl- |
|
Definition
seizure free 2 yrs complete control in 1 yr age>2, <35 only 1 type of seizure normal EEG while on therapy |
|
|
Term
withdrawl should be done over _ months- |
|
Definition
|
|
Term
the acute dose depednt ADEs-2 |
|
Definition
neutoxic- sedation, dizzy cognition impairment |
|
|
Term
what classic drug is greater impair of cognition? which is least |
|
Definition
|
|
Term
which new AED causes most cognitive impair? |
|
Definition
|
|
Term
|
Definition
|
|
Term
long term osteoporis is assoc with what is the treatment? |
|
Definition
the classical AEDS Ca + Vit D |
|
|
Term
for ppl with epilepsy- is ther an increased risk of suice? |
|
Definition
|
|
Term
which hormone increases seizure effect why? |
|
Definition
|
|
Term
which hormone is seizure protective |
|
Definition
progesterone (increases GABA) |
|
|
Term
why do seizures occur rihgt before/during menstration? |
|
Definition
bc estrogen >>> progesterone |
|
|
Term
AEDs that are hepatic inducers do what-2 |
|
Definition
increase steroid hormone decrease fee sex hormones |
|
|
Term
AEDs that decrease oral contraceptives-4 |
|
Definition
all classicla but valproate topiramate, oxacarbamezapine, lamotrigine, |
|
|
Term
valproate is associ with what disease |
|
Definition
|
|
Term
during pregnancy what happens to seizures |
|
Definition
1/3 increase but 1/3 decrease |
|
|
Term
what 2 drugs cause cleft palate and heart malform if used in preggos |
|
Definition
|
|
Term
what 2 drugs cauase spina bifida if sued in preggos |
|
Definition
valproate and carbamezapine |
|
|
Term
many birth defects can be prevented by supplementaiton of |
|
Definition
|
|
Term
if using 1st gen AEDS, to reduce hemmorhage need to give in last month |
|
Definition
|
|
Term
*higher protein binding = less in breast milk |
|
Definition
|
|
Term
status epilepticus is when seizure lasts? what else cna be defined as it? |
|
Definition
30 minutes reccurrent seizures without period of conciousness |
|
|
Term
what is the more common SE? |
|
Definition
generalized convulsive (almost msot severe) |
|
|
Term
incidence of generalized SE is higher for what ages |
|
Definition
|
|
Term
nonconvulsive SE has what continuous state |
|
Definition
twilight/altered conciousness |
|
|
Term
drug of choice for SE why? |
|
Definition
lorazepam (is IV) higher affinity for BDZ recpt than diazepam |
|
|
Term
for the SE drugs which gets to brain first? which stays longer tho? |
|
Definition
|
|
Term
second line treatment for SE |
|
Definition
phenytoin fosphenytoin (will have less phlebitis)and cna infuse faster |
|
|
Term
|
Definition
|
|