Term
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Definition
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Term
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Definition
Irreversable Platelet Inhibitor (ADP Rec. Blocker)
CYP2c19 Testing (asians) |
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Term
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Definition
Anti platelet
more bleeding than clopidogrel |
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Term
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Definition
Reversible* Antiplatelet
ADR-dyspnea, uric acid |
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Term
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Definition
| IIb/IIIa receptor antagonist |
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Term
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Definition
IIb/IIIa receptor antagonist
stents |
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Term
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Definition
| IIb/IIIa receptor antagonist |
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Term
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Definition
Direct coronary vasodilator (antiplatelet)
Oral:TIA/CVA reduction
IV: CAD diagnostic (stress test)
*Severe HA |
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Term
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Definition
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Term
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Definition
Indirect Thrombin Inhibitor
5000 SQ q8 for DVT proph
Renal dysfunction
thrombus may still grow |
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Term
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Definition
Factor Xa inhibitor
Non Valvular AF
6-10h AFTER surgery, CrCl>30 |
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Term
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Definition
Factor Xa inhibitor
Non valvular AF |
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Term
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Definition
LMWH SQ
Better for treatment |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Direct Thrombin INhibitor
Keep tightly capped, no pillboxes
ADR-Dyspepsia/Gastritis, >GI bleed |
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Term
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Definition
Direct Thrombin Inhibitor
*Give for HITTS |
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Term
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Definition
| Direct Thrombin INhibitor |
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Term
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Definition
| Direct Thrombin Inhibitor |
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Term
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Definition
Fibrinolytic TPA
For Stemi, PE, Stroke, CVL clearance |
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Term
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Definition
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Term
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Definition
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Term
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Definition
For Acute Gout Flares (3rd Line)
Strong 3A4 inhibitor (clarithro) and Pg Inhibitor (cyclosporine)
**DIarrhea |
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Term
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Definition
Gout-Xanthine Oxidase Inhibitor
*Paradoxical Flare, Rash->SJS
*Allopurinol Hypersensitivity Syndrome-F/Hep/ARF/Eosinophilia |
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Term
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Definition
| Gout- Xanthine Oxidase Inhibitor |
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Term
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Definition
Gout- Urate Excretor
Need CrCl >50
ADR - *Acute Flare, UA stones |
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Term
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Definition
Gout- Urate Excretor
Last Line chronic
*Tophi Debulker
ADR- Severe gout Flare |
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Term
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Definition
Non-Biologic DMARD
Hold for sick in hospital, supplement folate
*Abortion Drug!
ADR- Pulmonary and Liver fibrosis |
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Term
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Definition
Non Biologic DMARD
2nd line to MTX
*Teratogen-D/C and take Cholestyramine for wanted Preg.
ADR- *Bad Diarrhea |
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Term
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Definition
Non Biologic DMARD
*Need Ophtho Exams
*Dont give to g6pd |
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Term
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Definition
Non Biologic DMARD
*Sulfa Rash
*Hemolysis in g6pd |
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Term
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Definition
Biologic DMARD - TNF Inhibitor
qwk |
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Term
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Definition
Biologic DMARDS- TNF inhibitor
mod-severe arthritis |
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Term
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Definition
Anti-Metabolite Transplant
*Problematic w/ Allopurinol and ACE
ADR-Myelosuppression
Can use for RA/Vasculitis |
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Term
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Definition
Anti-Metabolite Transplant
ADR- *Myelosuppression, **Black Label Teratogen**
Off label GVHD |
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Term
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Definition
Calcineurin Inhibitor Transplant
Monitor Troughs, Macrolides knock this out (3A4)
ADR- *Nephrotoxic, *DM, *Gingival Hyperplasia, HTN
Can use for RA |
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Term
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Definition
Calcineurin Inhibitor Transplant
ADR *PTDM, HTN
can use for atopic dermatitis |
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Term
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Definition
Corticosteroid for Transplant
*Proximal Myopathies with high dose |
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Term
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Definition
| MTOR Inhibitor Transplant |
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Term
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Definition
| MTOR inhibitor transplant |
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Term
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Definition
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Term
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Definition
Class 1a Antiarhythmic
*Syncope
*Cinchonism |
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Term
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Definition
Class 1a Antiarrhythmic
*Reversible Lupus rxn |
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Term
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Definition
Class 1a Antiarrhythmic
*Glaucoma
*BPH |
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Term
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Definition
Class 1b Antiarrhythmic
*CNS toxicity- tremor, seizure |
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Term
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Definition
Class 1b Antiarrhythmic
*CNS Toxicity- Dizzy/lightheaded |
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Term
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Definition
Class 1c Antiarrhythmic (Need ECHO!)
*For Proarrhythmias
**Black Box- Not for AMI pt!** |
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Term
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Definition
Class 1c Antiarrhythmic (Need ECHO!)
Dysguesia- altered taste
lupus like rxn |
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Term
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Definition
Class III antiarrhythmic
*Racemic Mix
Avoid B-blockers and CCBs |
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Term
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Definition
Class III antiarrhythmic
*Restricted Distribution-> Hospital and 3d obs |
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Term
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Definition
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Term
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Definition
Class III antiarrhythmic
for VF, VT, cardioversion, AF proph
*Increases Dig Toxicity
ADR- fibrosis, thyroid, occular, blu/gray skin, cardiac tox |
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Term
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Definition
Class III antiarrhythmic
Non Iodinated analogue of amioderone
*Increase INR with Warfarin
Dont use in CHF, AV block, SSS, or Brady--> AF |
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Term
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Definition
Antirrhthmic
Use in HF pt
*Measure Serum Troughs (.5-.8 for HF)
Dig Toxicity! dont decrease K or Mg |
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Term
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Definition
Diuretic-Proximal tubule and Loop of Henle
*Decrease ICP, GU irrigant for Turp
*Kidney dumps free water! |
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Term
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Definition
Diuretic-Block Nacl and HCO3 resorption at renal tubule (CAI)
*Acute Mountain Sickness
*Metabolic Alkylosis |
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Term
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Definition
Loop Diuretic
Interax- NSAIDS (retain Na), DM meds
ADR- Hypokalemia/mag, Hyperglycemia |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Loop Diuretic
*No Sulfa Group
**Ototoxicity |
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Term
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Definition
Thiazide- Distal Convoluted Tubule
*Increase Ca reabsorption, decrease kidney stone |
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Term
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Definition
| Thiazide- Distal convoluted tubule |
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Term
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Definition
Thiazide-distal convoluted tubule
Good when CrCl<30
Use c Loop for synergy |
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Term
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Definition
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Term
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Definition
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Term
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Definition
K sparing diuretic (anti aldosterone)
*Teratogen
MR receptor blocker |
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Term
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Definition
K sparing diuretic
MR receptor blocker |
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Term
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Definition
K sparing Diuretic
Distal dubule |
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Term
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Definition
K sparing diuretic
*Nephrotoxicity and Stones! |
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Term
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Definition
ACEI
Use HTN c LVH, *AMI/HF c Systolic dysfn, CKD
ADR-*Cough, *Teratogen, *Hyperkalemia, *Angioedema in blacks |
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Term
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Definition
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Term
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Definition
| ARB- Block angiotensin II to AT1 receptors |
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Term
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Definition
Renin Inhibitor
*P-gp inhibitors may increase concentration |
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Term
| Prazosin, Terazosin, Doxazoisin |
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Definition
A-Blockers- Arterial Vasodiators
HTN and BPH
Do Not use with NITRATES, decongstants
ADR- *FLoppy IRIS, Postural Hypotension |
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Term
| Propranolol, Nadolol, Timulol |
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Definition
B-Blockers, Non selective
watch for bronchospasm, raynauds |
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Term
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Definition
B Blocker- Selective
*SSRI inhibit 2D6 |
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Term
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Definition
a and B blocker
2C9 and 2D6
* Floppy Iris |
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Term
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Definition
a and B blocker
IV
Floppy Iris |
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Term
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Definition
CCB dihydropyridine
Peripheral Vasodilator for HTN, Angina, Raynauds
ADR- *Edema, Reflex Tach, *Gingival Hyperplasia |
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Term
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Definition
CCB- Nondihydro.. Decrease cardiac contractility
Use SVT, AF... NOT CHF
*Constipator
Careful with B blockers and Dig |
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Term
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Definition
CCB - Nondyhydro.. decrease cardiac contractility
*Constipation
Use SVT, AF.. not CHF
careful with b blockers and dig |
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Term
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Definition
Central a2 agonist
Decrease PVR, HR, BP
*HTN CRISIS with abrupt withdrawl |
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Term
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Definition
Central A2 agonist
Decrease PVR, HR, BP
*For pregnant
*Lactation, +coombs, sedation |
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Term
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Definition
Direct Vasodilator-Relax art SM=decrease PVR
Use-HTN urgency, HF (Bidil), Preeclampsia
ADR- Lupus like rxn |
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Term
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Definition
Direct Vasodilator- Relax art SM= decrease PVR
Use- HTN, Alopeica (last line adjunct)
ADR- Fluid retention, reflex tach, hirsutism |
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Term
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Definition
Statin
less myalgias, better for liver dz |
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Term
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Definition
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Term
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Definition
Statin
Take QHS
major 3A4 substrate, increased myalgias |
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Term
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Definition
statin
less myalgias, better for liver dz |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Cholesterol Absorption inhibitor
small intestine, decrease LDL |
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Term
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Definition
BAS-decrease LDL
Bind and absorb other drugs
GI intolerance |
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Term
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Definition
BAS-decrease LDL
Bind and absorb other drugs
GI intolerance |
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Term
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Definition
BAS-decrease LDL
Bind and absorb other drugs
GI intolerance |
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Term
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Definition
Target HDLs and TGs
**FLUSHING
*aggravate glucose and gout
start low go SLOW |
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Term
| Gemfibrozil, Fenofibrate, fenofibric acid |
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Definition
Fibrate-TGs
*Myositis and Rhabdo possible |
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Term
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Definition
| decrease TG synthesis and increase TG clearance |
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