Term
| Deoxyribonucleotides are formed by |
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Definition
| the reduction of ribonucleoside diphosphates. |
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Term
All deoxyribonucleotides are synthesized from ........... by the enzyme ribonucleotide reductase. |
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Definition
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Term
nAll deoxyribonucleotides are synthesized from ribonucleotides by the enzyme ....... |
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Definition
ribonucleotide reductase. (highly regulated) |
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Term
Deoxthymidylate (dTMP) is
formed by |
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Definition
methylation of deoxyuridine 5’-mono Phosphate (dUMP) |
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Term
| what is the precursor for all the pyrimidine nucleotides???? |
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Definition
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Term
nPyrimidine nucleotides are degraded to ....? |
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Definition
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Term
Nucleotide mono-, di-, and triphosphates are ....... |
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Definition
interconvertible
For example - UMP → UDP → UTP |
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Term
Specific nucleoside (X) monophosphate kinases make |
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Definition
nucleoside diphosphates
XMP + ATP -->XDP + ADP |
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Term
• A nucleoside diphosphate kinase, with broad substrate specificity,interconverts............ (this enzyme uses both ribo- and deoxynucleosides as substrates) |
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Definition
| dinucleosides and trinucleosides |
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Term
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Definition
nNAD
nFAD
nCoenzyme A (CoA) |
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Term
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Definition
| nicotinamide adenine dinucleotide |
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Term
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Definition
| Flavin Adenine Dinucleotide |
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Term
nPRPP is the KEY molecule in |
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Definition
¨ de novo synthesis of purine and pyrimidine nucleotides
¨salvage of purine and pyrimidine bases
¨ and synthesis of NAD+. |
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Term
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Definition
| 5-phosphoribosyl-1-pyrophosphate |
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Term
| dUMP can be converted to dTMP using this enzyme: |
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Definition
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Term
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Definition
| an enzyme targeted by anticancer drugs such as 5-flurouracil |
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Term
nThe regeneration of THF from DHF produced in the thymidylate synthase reaction requires |
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Definition
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Term
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Definition
| an enzyme targeted by the drug, methotrexate. |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
nAcyclovir a purine analog, and AZT a pyrimidine analog are used in the treatment of |
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Definition
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Term
| Acyclovir, a purine analog, and AZT a pyrimidine analog are |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Cystonesine arbinoside is |
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Definition
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