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Exam 2-Neuro
Unit 5 & 6
214
Other
Undergraduate 3
09/19/2014

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Term
what is the definition of learning how to move?
Definition
over time behavior changes in relation with functional neural anatomy
Term
what is the internal reference of correctness?
Definition
you can internally represent the movement and how to do it correctly.
Term
when do you have the internal reference of correctness?
Definition
when you learn to perform a movement the proper way and can distinguish when you do it wrong.
Term
T/F you will already have an internal reference of correctness before you learn a movement.
Definition
false
Term
what are the three main steps to changes in behavior and neuroanatomy?
Definition
gradual progression->
neural modifiability->
gradual structural changes
Term
what is the mechanism of long term potentiation?
Definition
repetition
Term
what is long term potentiation?
Definition
persistence of a neural impulse to internalize a movement to change the efficiency of the synapse
Term
what is perception?
Definition
interpretation of stimulus events
Term
what is cognition?
Definition
interpretation through multiple cortices
Term
what two structures are an important part of the motor cortex?
Definition
baso ganglia
cerebellum
Term
during the interpretation of a stimuli, what happens sub cortically?
Definition
millions of highly myelinated axons are interpreting stimulus events
Term
what are the three forms of learning?
Definition
perceptual learning
procedural learning
declarative learning
Term
what is perceptual learning?
Definition
a process of long lasting improvement in performing perceptual (visual, auditory, tactile, olfactory) tasks based on experience and practice
Term
T/F perceptual learning is activity dependent
Definition
true
Term
what are the two main points of perceptual learning?
Definition
simple sensory discrimination
categorizations of spatial and temporal patterns
Term
T/F perceptual learning is not retained throughout life.
Definition
false
is
Term
give an example of the cognitive processes that founded upon perceptual learning.
Definition
language
interacts with other kind of learning
based on changes in neural circuitry
retained throughout life
Term
T/F the ability to extract information from sensory displays improves dramatically with practice.
Definition
true
Term
name three everyday properties that are associated with perceptual learning.
Definition
motion discrimination
orientation sensitivity
visual search
Term
if perceptual learning can become better with practice, what are some of the improvements that can be made?
Definition
get better at discriminating between different stimuli of different categories
become less sensitive to differences between two instances of the same category
Term
what does the higher order sensory association areas store?
Definition
data
size, color, texture, shape
Term
what does procedural learning refer too?
Definition
tasks that can be learned with out attention or conscious thought
Term
what two words should you think of when you think of procedural learning?
Definition
skills and habits
Term
explain the mechanism behind procedural learning
Definition
memory below the level of conscious awareness that when needed can be retrieved and utilized for the EXECUTION OF THE INTEGRATED PROCEDURES INVOLVED IN BOTH COGNITIVE AND MOTOR SKILLS
Term
T/F with procedural learning, you can tell internally how to ride a bike.
Definition
false
can tell the sensation of riding a bike but cannot tell internally
Term
what does procedural memory guide?
Definition
guides our actions but resided below the level of conscious awareness
Term
T/F procedural memory is a type of long term memory
Definition
true
Term
explain how procedural memory is specifically implicit memory.
Definition
by repeating a complex activity over and over again until all of the relevant neural systems work together to automatically produce the activity
Term
what is declarative learning?
Definition
learning that requires conscious processes such as awareness and attention, resulting in knowledge that can be expressed consciously and expressed in a form other than that which was learned
Term
what are the two sub-parts of declarative memory?
Definition
episodic
semantic
Term
what is episodic?
Definition
describing an event or occurrence
Term
what is semantic?
Definition
meaning and understandings
Term
what part of the brain is associated with declarative learning?
Definition
temporal lobe
hippocampus
Term
what is Adam's Closed Loop Theory of Motor Learning?
Definition
sensory feedback is used for ongoing production of skilled movements
Term
what year did Adam create his theory?
Definition
1971
Term
what are the two types of memory proposed by Adam?
Definition
memory trace
perceptual trace
Term
what is memory trace?
Definition
recollection and initiation of movement
Term
what is perceptual trace?
Definition
perceiving what its like
internal reference of correctness
Term
what are some ways to challenge Adam's Closed Loop Theory?
Definition
can produce movement without sensory feedback
accurately produce movements never performed before
unlikely a human could store a separate series of perceptual traces for every movement they learned
Term
what is Schmidt's Schema Theory of Motor Learning?
Definition
abstract representation stored in memory following multiple presentations of a class of stimuli
Term
what year did Schmidt propose his theory?
Definition
1975
Term
According to Schmidt, what four things does a person store to memory?
Definition
1) initial movement conditions
2) parameter used in the generalized motor program
3) outcome of the movement in terms of knowledge of results(KR)
4) the sensory consequences of the movement (how did it look)
Term
what is the basic take away fro Schmidt's Theory?
Definition
you only need a set of general rules, which can be applied to a variety of contexts.
Term
what are the four steps of the schema theory?
Definition
1) initial movement
2) parameter used in the generalized motor program
3) outcome of the movement in terms of knowledge of results
4) the sensory consequence of the movement
Term
what is another name for Bernstein's Self Organizing Theory?
Definition
Dynamical Theory
Term
what is Bernstein's Self Organizing Theory?
Definition
performance of any kind of movement results from an infinite variety of possible combinations (or degrees of freedom) of neuromuscular and skeletal elements
Term
what does Bernstein's Self Organizing Theory say motor development is dependent on?
Definition
brain maturation and adaptations to constraints of the body and exogenous conditions
Term
what are the basics of Bernstein's Theory?
Definition
there is a general representation of motion and then you can make an adjustment based on the external environment stress which is possible because systems are able to work together
Term
what was significant about Bryan and Harter's telegraphy experiment?
Definition
they found that telegraphy students had periods of improvement followed by plateaus and these plateaus were the result of habits that interfered with further development until a new habit was formed
Term
what is the initial stage of learning?
Definition
cognitive stage
Term
what is the cognitive stage?
Definition
most of the learning can be characterized as verbal-cognitive rather than producing the actual desired motor patterns
Term
describe performance in the cognitive stage?
Definition
slow but large gains are made
under close sensory guidance
variable time of performance
finding strategies to achieve the goal
Term
what is the intermediate stage of learning?
Definition
the performer now knows how to produce the basic motor patterns and has eliminated gross error with increase in speed
Term
describe performance in the intermediate stage.
Definition
variability decreases because the performer is able to focus on the skill
Term
how long does the intermediate stage usually last?
Definition
days or weeks
Term
what is the advanced stage of learning? (Hint: where you ideally want to be).
Definition
autonomous
Term
what is the autonomous stage?
Definition
the performer is able to demonstrate a high level of proficiency that is characterized by automaticity
Term
T/F conscious thought is needed in the autonomous stage of motor learning.
Definition
false
Term
what is a big deciding factor on getting a performer to the autonomous stage?
Definition
the quality and type of practice
Term
describe the performance of the autonomous stage.
Definition
the performance is so well learned that secondary tasks can be performed without interfering with the primary outcome
Term
what is William James' definition of attention?
Definition
the taking possession by the mind, in clear and vivid form, of one out of what seem reveal simultaneously possible trains of thought
Term
T/F you can focus on two things at once.
Definition
false
can only focus on one, only one stimulus with have your attention
Term
how can we measure, quantify consciousness?
Definition
fMRI
EEG
Term
what is selective attention when it is voluntary?
Definition
limit your attention to a signal
Term
what is selective attention when it is involuntary?
Definition
where the stimuli is so compelling that your attention is drawn toward the stimuli
Term
what is limited capacity?
Definition
focusing attention on an aspect of the environment
Term
what are the two ways to look at limited capacity? (hint: A and B)
Definition
may be viewed as a limiting factor in that you are unable to attend to something else

if you attend to B, then A suffers
Term
T/F when attaining to task A, task B will take longer due to limited capacity
Definition
true
Term
what was Keele's experiment in 1978?
Definition
words in certain colors
Term
what is Keele find in his experiment?
Definition
recognition of word and color simultaneously interfered by requiring the subject to interpret the stimuli before responding
Term
what is the psychological refractory period?
give an example.
Definition
when two stimuli are presented (in close proximity) the time taken to react to the 2nd stimulus will always take longer

in football when a runner "shakes" the defender. The defender is cognitively focused on the fake (first stimulus) and reacts slower to the runner going to other way
Term
what factors influence refractoriness in sport?
Definition
practice
complexity
stimulus-response compatibility
Term
what is the bottle-neck theory?
Definition
limited capacity to handle multiple stimuli at one time
Term
what is the basis of anticipation?
Definition
anything that involves moving, perceiving and adjusting to, take into account upcoming stimuli and you don't have to identify task A, B, and C separately, but use them to respond faster
Term
what are the three types of anticipation and who identified them?
Definition
receptor
effector
perceptual

Poulton 1957
Term
what is receptor anticipation?
Definition
performer detects upcoming events with various sensory receptors
Term
what is effector anticipation?
Definition
performer takes into account how long his/her movement will take when preparing to initiate an action
Term
what is perceptual anticipation?
Definition
predictable environmental events that are not viewed directly
Term
what is temporal anticipation deal with?
give an example.
Definition
false starts
there is a cost to benefits ratio when you anticipate environmental events.

in sprinting the runner attempts to time the start coincident with the gun that could result in disqualification
Term
what is the the runner using when he/she attempts to time the start coincident with the gun?
Definition
fore-period
Term
what can reduce the decision making process?
Definition
knowing the stimuli that is going to be presented
knowing what kinds of responses are required
Term
what is spatial or event anticipation?
Definition
having advance information enables one to anticipate and by-pass response selection, which will shorten response time
Term
what does feedback concern?
Definition
information that is provided to the learner about the performance of a movement or skill
Term
where can feedback come from?
Definition
both internal or external sources
Term
what is intrinsic feedback?
give an example.
Definition
use the senses to make a decision about movement

where is the body?
Term
what is augmented feedback?
give examples.
Definition
knowledge of results
knowledge of performance
use these to make a decision about the movement

how did it look?
did you hit the target?
Term
what are the dimensions of augmented feedback?
Definition
concurrent
knowledge of results
terminal
knowledge of performance
Term
what is the concurrent dimension of augmented feedback?
Definition
presented during the movement
Term
what is knowledge of results in terms of augmented feedback?
Definition
verbalized or verbalizable post-movement information about the outcome of the movement
Term
what is the terminal dimension of augmented feedback?
Definition
presented after the movement
Term
what is knowledge of performance in terms of augmented feedback?
Definition
verbalized or verbalizable post-movement information about the nature of the movement pattern
Term
what is the instrumental learning paradigm?
Definition
the knowledge of results are provided at the end of the trial to increase the likelihood of a correct response
Term
what have studies shown with knowledge of results?
Definition
KR increases the performance
Term
what did Bernstein say about the practice context?
Definition
motor learning context should force the learner to problem solve from repetition to repetition

that repeating the same task over an over again does not promote problem solving
Term
what did Craik and Lockhart say about the practice context?
Definition
a learning context that is made to be difficult enhances learning by forcing the learner to process information more thoroughly and deeply
Term
what is contextual interference?
Definition
switching from one skill to another or changing the context in which the task is practiced from trial to trial
Term
T/F studies have shown the contextual interference enhances learning, retention and transfer
Definition
true
Term
what are the key elements of contextual interference?
Definition
subjects respond to situations of high and low interference with correspondingly high or low levels of elaborative and distinctive processing

the order in which items are practiced determines the level of interference

if the times practiced are quite similar the subject experiences greater interference
Term
if all the tasks are presented together, learning will be low at first but will become better as the attention intervals increase. the information will be retained better. what is this an example of?
Definition
contextual interference
Term
what are the three component parts of the human memory?
Definition
sensory
short-term
long-term
Term
what is implicit memory?
Definition
unconscious
Term
what is procedural memory?
Definition
skills and habits
Term
what is declarative memory?
Definition
facts and events
Term
where are short term memories located?
Definition
in the prefrontal cortex and temporal lobe
Term
where are semantic and episodic memories located?
Definition
frontal and temporal lobes
Term
where are procedural memories located?
Definition
cerebellum and motor cortex
Term
what is the hippocampus important for?
Definition
the consolidation of semantic, episodic and procedural memories
Term
what are emotional memories dependent on?
Definition
amygdala
Term
T/F memory is plasticity as a result of repetition.
Definition
true
Term
explain the track of consolidation of memory.
Definition
external stimulus
initial processing
put into short-term memory
through repetition the stimulus is repeatedly put into short-term memory
changes in neural coding causes the stimulus to be put into long-term memory
Term
what is short-term sensory store (STSS)?
Definition
from an information processing standpoint, the system receives tremendous amounts of information that is retained for brief periods while we consciously (or unconsciously) attend to select pieces of information
Term
what is the storage duration for the STSS?
Definition
less than one second
Term
what is the type of coding for the STSS?
Definition
very literal
Term
what is the capacity for the STSS?
Definition
seemingly endless
Term
what was Sperlings experiment in 1960 concerning the STSS?
Definition
showed four rows of letters with four different tones identifying each row.
the tone was showed played first and then the letters were shown - resulted in high capacity to remember all the letters
when the tone was presented after the letters were shown the capacity to remember the letters decreases
Term
what is short-term memory?
Definition
memory that comes from the short term sensory memory or from long term memory

also described as a holding area with a limited capacity
Term
how does man seek to control his environment?
Definition
one the fly with short term memory
Term
T/F increased retention interval = increased performance.
Definition
false
decreased performance
Term
what is long term memory?
Definition
once an item or movement is practiced, that information moves from short term memory to long term memory
Term
what does long term memory appear to be?
Definition
permanent
extremely large
Term
what three systems are included in long term memory according to Tulving?
Definition
procedural
episodic
semantic
Term
what does procedural memory refer to?
Definition
how to do
Term
what does episodic memory refer to?
Definition
personally experienced events
Term
what does semantic memory refer to?
Definition
our general representation o the world and events surrounding our world
Term
how does long term potentiation effect our memory?
Definition
there is an X number of pre and post synapses, and this number is changed it increase the strength of the synapse
Term
what is the primary neurotransmitter of the nervous system?
Definition
glutamate
Term
what is memory consolidation?
Definition
a category of processes that stabilize a memory trace after the initial acquisition
Term
what two processes make up memory consolidation?
Definition
synaptic consolidation
systems consolidation
Term
when does synaptic consolidation occur?
Definition
within the first few hours after learning
Term
what is the mechanism behind synaptic consolidation?
Definition
long term potentiation
Term
what are the three stimuli that trigger the release of BDNF?
Definition
exercise
cognitive activity
intermittent fasting
Term
how can you form strong neural connections?
Definition
increase the number of TrkB receptors
increase BDNF
Term
what does synaptic consolidation trigger?
Definition
downstream transcription to copy DNA to make more TrkB receptors and BDNF
Term
how can you decreases chances of dymensia?
Definition
increase BDNF by being lean, engage in vigorous activity, engage is cognitive activity
Term
what do elevated BDNF levels result in?
Definition
increase in neural connections
Term
T/F to elevate BDNF is activity dependent.
Definition
true
Term
what is systems consolidation?
Definition
novel information which is encoded and registered in both the hippocampus and cortical regions
Term
what is the hippocampus-dependent stage?
Definition
memory is retained in the hippocampus for up to one week after initial learning
Term
T/F systems consolidation is related to "move it or lose it"
Definition
true
Term
what structure is a part of systems consolidation that can support memory indefinitely?
Definition
neocortex
Term
what is non associative habituation sensitization?
Definition
habituate to the stimulus as a result you reduce the connections as you override the response to the stimulus
Term
what is an example of associative classical operant?
Definition
Pavlov's dogs when he would ring the bell and feed them
Term
explain systems consolidation.
Definition
an experience triggers the hippocampus
as the neurons continue to fire they become effective
Term
T/F systems consolidation is not activity dependent.
Definition
false, it is activity dependent
move it or lose it
Term
what is believed to be where long-term memory is stored?
Definition
neocortex of the temporal lobe
Term
what is located within the temporal lobe?
Definition
hippocampus
amygdala
Term
the hippocampus and the amygdala are responsible for forming what type of memory?
Definition
declarative memory
Term
what is the amygdala associated with?
Definition
emotions
Term
what did Lashley find in his rat experiments in the 1920s?

big find?
Definition
hw would lesion the temporal lobe of the rat and he found that there was a relationship between the learning the maze or remembering how to navigate the maze with the size of the lesions (not the location)

memory is distributed among neurons of the cerebral cortex
Term
what did Hebb's 1949 book "Organizations of Behavior" argue?
Definition
internal representation of objects consists of all the cortical cells that are activated by the external stimulus
Term
what did Hebb's work find?
Definition
engram could include the same cells making up sensation and perception and destruction of some of the cells in the assembly would not eliminate memory
Term
what is engram?
Definition
located across neurons making up cell assembly which memory trace is stored
Term
T/F over time engram becomes so connected that you don't need to register a whole piece to know what it is.
Definition
true
Term
what is Delayed Non-Match to Sample (DNMS)?
Definition
the length of the retention interval will change the memory recognition
Term
what is the role of the parietal lobe?
Definition
integrating sensory information from multiple sources
from a motor standpoint supports sensory awareness dealing with touch and visuospacial relationships
Term
what is the information from the parietal lobe used for?
Definition
to help control motor behavior controlling movement of the arm, hand, and eye movements
Term
T/F the parietal lobe understands that we are in space.
Definition
true
Term
what is happening subcoritcally?
Definition
highly, myelinated axons are sending information to the cortices
Term
where is the basal ganglia?
Definition
in the medial temporal lobe
Term
what is the basal ganglia?
Definition
a group of nuclei in the brain interconnected with the cerebral cortex, thalamus and brain stem
Term
where does the basal ganglia play a role? give the steps.
Definition
initial thought to move
basal ganglia
back to motor cortex
spinal cord
movement
Term
T/F the basal ganglia isn't needed for voluntary movement.
Definition
false
ABSOLUTELY needed for voluntary movement
Term
what is the striatum?
Definition
part of the basal ganglia, important in the secretion of dopamine
Term
what do rodent studies show with lesions to the striatum?
Definition
will produce deficits in procedural memory
Term
during the early stages of learning, what is the basal ganglia associated with?
Definition
sensorimotor associations being made with the prefrontal cortex
Term
during late stages of learning, what is the basal ganglia associated with?
Definition
the storage of procedural learning experiences
Term
what is the locus of declarative memory (facts and episodic memory)?
Definition
hippocampus
Term
where is the hippocampus located?
Definition
in the medial temporal lobe
Term
what is the function of the entorhinal cortex (EC)?
Definition
a hub fing a widespread network for memory and navigation and serves as the main interface between the hippocampus and the neocortex
Term
where is the EC located?
Definition
medial temporal lobe
Term
what does the EC-hippocampus system play and important role in?
Definition
autobiographical/ declarative/ episodic memories and in particular spatial memories and in particular spatial memories including memory formation, memory consolidation, and memory optimization in sleep
Term
our awareness of general properties of the context as well as very specific representations of information comes from where?
Definition
EC-hipposcampus system
Term
what are place fields?
Definition
grid cells that allow us to navigate in space
Term
what is the Theory of Prefrontal Cortex Function?
Definition
cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represents goals and means to achieve them
Term
what does the cerebellum play a role in?
Definition
integration of sensory perception and motor output
Term
how does the cerebellum fine-tune motor movements?
Definition
constant feedback
Term
what is the primary motor responsible for?
Definition
generating the neural impulses controlling execution of movement
Term
same the secondary motor cortices.
Definition
posterior parietal
pre-motor
supplementary motor area
pre-supplmentary motor area
Term
this area is involved in planning actions and refining movements based upon sensory input. in order to do these actions the area needs help from what two structures?
Definition
pre-motor cortex

basal ganglia
cerebellum
Term
this area is implicated in the planning of motor actions and bimanual control and implicated in actions under internal control (performance of a sequence of movements)
Definition
supplementary motor area
Term
where is the primary motor cortex located?
Definition
the posterior portion of the frontal lobe
Term
what is the name of large motor neurons in primary motor cortex(M1)?
Definition
Betz cells
Term
T/F M1 is about highly controlled voluntary movements
Definition
true
Term
LTP does what to the pre and post synapse that helps with movement?
Definition
better, stronger connectivity for more precise movements

allows for the right type and number of muscle fibers to create the movement

high level of control
Term
T/F LTP remodels only the pre synapse.
Definition
false
remodels both the pre and post synapse
Term
T/F plasticity is activity dependent.
Definition
true
Term
what part of the neuromuscular junction is altered as a result training?
Definition
the terminal branch and the post-synaptic receptors of the muscle fibers that it innervates
Term
in relation to calcium what increases due to neuroplasticity?
Definition
voltage-gated calcium channels on the presynaptic neuron to ensure action potential

t-tubule channels to increase release of calcium to initiate power stroke
Term
in relation to the SNARE complex what does plasticity do?
Definition
improve the efficiency of membrane fusion as well as increased expression of membrane proteins that contribute to fusion
Term
explain calcium activation of transcription factors.
Definition
signaling molecule that allows for changes in hardware, downstream from calcium entering the cell that leads to copies of DNA
Term
what does LTP improve?
Definition
the postsynaptic cell's sensitivity to neurotransmitter in large part by increasing the activity of existing receptors and by increasing the number of receptors on the postsynaptic cell surface
Term
what helps to express agrin?
Definition
repetition
Term
what is MUSK?
Definition
muscle specific kinase
Term
what does MUSK and agrin do?
Definition
increases the changes of the AP getting to the post-synaptic cell
Term
agrin represents what?
Definition
positive signals
Term
how can skeletal muscle adapt to stimuli?
Definition
contractile activity
loading conditions
substrate supply
Term
mitochondrial biogenesis is triggered by what?
Definition
elevations of intracellular Ca++
Term
what does PGC-1 do?
Definition
auto regulates its gene expression
Term
what does PGC-2 do?
Definition
induces the expression of mitochondrial transcription factor
Term
how is hypertrophy induced/
Definition
satellite cells
Term
how is Ca2+ released during anaerobic training?
Definition
large volume boluses
Term
how is Ca2+ released during aerobic training?
Definition
small amounts continuously released to sustain activity of muscle to copy structures
Term
what does DHP interface with?
Definition
ryanodine receptors
Term
the interface of DHP and ryanodine receptors trigger what?
Definition
trigger release of Ca2+ from the SR
Term
what is DHP?
Definition
Ca2+ sensitive receptor
Term
what is key as a response to stress?
Definition
adaptive structural events
Term
explain signaling pathways and their relation to physiological stress?
Definition
signaling pathways are master regulators that transduce physiological stress into transcriptional adaptations
Term
T/F overload triggers the pathways that ultimately copy DNA
Definition
true
Term
what is the purpose of creating more mitochondria?
Definition
to generate more energy
Term
what two molecules trigger upstream mitochondrial biogenesis?
Definition
Ca2+ and AMPK
Term
what is important about Ca2+ and AMPK?
Definition
they trigger PGC-1 alpha which makes it possible for nuclear DNA to enter the mitochondria, where 13 mitochondrial DNA are activated to make more and larger mitochondria to produce more ATP
Term
load promotes hypertrophy and the activation of what types of cells?
Definition
satellite cells
Term
what three things contribute to hypertrophy?
Definition
nutrients
IGF-1
mechanical load
Term
how can transcription be triggered?
Definition
nutrients
mechanical load
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