Term
| Describe the breadth of neuro regen. |
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Definition
| -extremely limited regen ability |
|
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Term
| What does an ischemic neuron look like? |
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Definition
|
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Term
| What is the major thing of path we see w/ viruses affecting the CNS? |
|
Definition
| -intranuclear or intracytoplasmic inclusions in neurons |
|
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Term
| What do we see on path w/ lysosomal storage d? |
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Definition
|
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Term
| What do we see w/ spongiform encephalopathies on path? |
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Definition
|
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Term
| What is Wallerian degen in axons? |
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Definition
| -response to severing or direct axonal damage w/ which DISTAL axon undergoes necrosis |
|
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Term
| Is regen better in central or peripheral nervous system? |
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Definition
|
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Term
| What is axon demyelination? Some etiologies? |
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Definition
-loss of oligo or Schwann cells
-distemper, CAE, globoid cell leukodystrophy, Afghan myelopathy |
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Term
| Via axonal regen (Wallerian degen) regen is by axonal ______. |
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Definition
|
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Term
| Are astrocytes or neurons more susceptible to ischemic damage? |
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Definition
|
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Term
| How do astroycytes respond w/ non=lethal rxns? |
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Definition
-function to fill in or wall off areas of necrosis
-small area: astrocytes proliferate to form a glial scar (focal gliosis)
-large area: wall off and leave cystic space |
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Term
| Are astrocytes or oligos more susceptible to ischemia? |
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Definition
|
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Term
| Where do CNS macrophages come from? |
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Definition
-microglia
-peripheral blood monocytes |
|
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Term
| Which cells are least susceptible to ischemic injury? |
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Definition
|
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Term
| What do microglia cells do in response to ischemic injury? |
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Definition
-ingest lipids beocming Gitter Cells
-eat necrotic neurons (called neuronophagia)
-eat red cells and become hemosiderin-laden (siderophages) |
|
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Term
| What are gitter cells? From what are they derived? Major stimuli? |
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Definition
-lipid-laden (foamy) macrophages in brain
-infiltrating blood monocytes or proiferating microglia-
-degen myelin and necrosis in brain |
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