Term
|
Definition
| -ability to detect true positives (few false negatives) |
|
|
Term
|
Definition
| -ability to detect true negatives (few false positives) |
|
|
Term
| In a 20 test biochemical profile, ___% of normal animals will have at least one abnormal result. |
|
Definition
|
|
Term
|
Definition
| Ability to detect true positives (few false negatives) |
|
|
Term
|
Definition
| Ability to dtect true negatives (few false positives) |
|
|
Term
| What is the formula for Predictive Values positive? |
|
Definition
| PV positive = TP / (TP+FP) X 100 |
|
|
Term
| What is the formula for Predictive Values Negative? |
|
Definition
| PV negative = TN / (TN+FN X 100 |
|
|
Term
| Predictive values depend on what three things? |
|
Definition
| Sensitivity, specificity, and disease prevalence |
|
|
Term
| True or False: Predictive values worsen when clinical suspicion for the disease is high. |
|
Definition
| FALSE; predictive values improve when clinical suspicion for the disease is high. |
|
|
Term
| What lab value indicates muscle injury in small animals? What about large animals? |
|
Definition
SA = CK (AST)
LA = CK (AST) |
|
|
Term
| What lab results indicate hepatocyte injury in small animals? What about in large animals? |
|
Definition
SA = ALT (AST)
LA = AST, SDH |
|
|
Term
| What lab results indicate cholestasis in small animals? What about in large animals? |
|
Definition
SA = DOGS ONLY = ALP, GGT
LA = GGT |
|
|
Term
| What are the two reasons for increased ezymes? |
|
Definition
Increased leakage from tissue
Increased production (induction) |
|
|
Term
| What are the 4 leakage enzymes (found free in cytoplasm or within organelles) |
|
Definition
|
|
Term
| What are the 2 induced enzymes (attached to membranes)? |
|
Definition
|
|
Term
| Where is creatine kinase (CK) normally found? What is its lab significance? |
|
Definition
Free in the cytoplasm of skeletal, cardiac, and smooth muscle cells
It is muscle specific when found in elevated levels |
|
|
Term
| Where is aspartate aminotransferase normally found in the body? Is it a leakage or induced enzyme? |
|
Definition
If is found in skeletal and cardiac muscle as well as hepatocytes
It is a leakage enzyme |
|
|
Term
| What can cause an increased serum CK? |
|
Definition
Skeletal muscle injury: necrosis, trauma, hypoxia (down cattle/horses)
Muscle break down (catabolism): especially in severely anorexic cats |
|
|
Term
| Does CK have a short or long half-life? What does this mean clinically? |
|
Definition
-very short half-life
-can normalize within 24-48 hrs after an acute injury |
|
|
Term
| Does AST have a short or long half-life? Is this muscle specific or not? |
|
Definition
-increases more slowly than CK, stays increased longer
-not muscle specific |
|
|
Term
| Is ALT liver specific or not? Are there mild or drastic increases with muscle injury? |
|
Definition
-liver specific in dogs, cats
-mild inc with severe muscle injury |
|
|
