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Exam 2
Addiction, Methods of Measuring Electrical Activity in the Brain (with examples of recording techniques), Hippocampus & Memory, Hippocampus & Spatial Navigation, Brain Imaging Techniques, tbc
63
Psychology
Undergraduate 3
10/27/2014

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Term
Addiction (also called dependence)
Definition
If referring to substance-related disorders, this is the strong desire to self-administer a drug of abuse. To be diagnosed as __________, a person must meet at least three of 7 criteria relating to patterns of consumption, craving, expenditure of time and energy in serving the _____ and impact on other aspects of the person's life.
Term
single cell recordings
Definition
this method of measuring electrical activity in the brain records neural activity but doesn't stimulate it. It just listens for when neurons are active and measures that.
Term
activity with behavior
Definition
The two types of designs for singe cell recordings of brain activity can be used to correlate _______ with _______, or measure activity after a stimulus.
Term
Stereotaxic procedure to implant electrodes
Definition
This procedure is used for single cell recordings and can be used on humans but is mostly used on animals. You'd refer to the atlas of the brain, find the part of the brain you're looking for and use landmarks on the surface of the skull to know where to start. From there you start at the origin (0,0) and use the atlas to tell you how many cm or mm to go and in which direction.. once you're in the right spot you put the electrode there.
Term
Hubel and Wiesel, 10mm
Definition
Who won the nobel prize for mapping the visual cortex by putting electrodes in cats and monitoring a specific cell while the cat watched a line on a screen move to different angles and waited for the cell to respond to that particular angle? How far did they move the line each time?
Term
simple cells respond to a specific orientation, complex cells  respond to a moving line.. they're specific for orientation and direction
Definition
What is the difference between simple cellos and complex cells?
Term
place cells
Definition
These cells create a mental map of the environment. The cells code for a particular place in the environment, generating an internal map.
Term
The rat's hippocampus was watched for action postentials as it was going through a maze. Cell A fires when a rat is in a particular space and cell B fires when it is in a different place. they found that Cells code for a particular place in the environment, generating an internal map. Memory of an environment can be stored as a specific combination of place cell activities in the hippocampus. Certain cells fire for each specific place you just have to remember the sequence.
Definition
The 2014 Nobel Prize winners did an experiment in which they studied place cells in rats What was the set up for their experiment? what'd they find?
Term
EEG- electroencephalograph
Definition
This method of measuring brain activity provides an index of overall electrical activity. It measures summed electrical potential from millions of neurons all over the brain because it is sensitive to dendritic currents.
Term
EEG is done with a cap that's put on the scalp, it doesn't go into the brain The amplitude of the waves are interpretted, huge slow waves= coma, small magnitude= awake and alert.
Definition
How is an EEG done? What is it primarily used for?
Term
ERP is formed by modifying EEG. the EEG signal is recorded as baseline (because the EEG makes noise but it is averaged out), then a stimulus is presented and the change in EEG in repsonse to the stimulus is averaged over many events. The waves peak at different times after the stimulus is represented, reflecting different stages of processing.
Definition
What is an Event Related Potential? How is it formed and read? Hoe does it work?
Term
reflects different stages of processing, peaks are labeled by how long it takes to react to stimulus
Definition
When the peaks of waves form (on ERP) after a stimulus is represented, what does that reflect? How are the peaks labeled?
Term

Single cells recordings good: excellent spatial resolution (how precise it is at measuring where the brain activity takes place), it can record deep within the brain within 50ms and it has excellent temporal resolution (measuring when activity happens). 

 

Disadvantage: invasiveness 

Definition
Good thing about Single cell recordings of measuring brain activity? Disadvantages?
Term

advantage: excellent temporal resolution and it's noninvasive. 

disadvantage: poor spatial resolution (can't tell where activity originates or go deep within the brain). 

Definition
Advantages and disadvantages of EEG's and ERP's?
Term
grid cells are place-modulated neurons whose multiple firing locations define a periodic triangular array covering the entire surface of a 2D environment.
Definition
A grid cell fires in evenly spaced peaks all over the box whereas place cells fire in one place in a box. What does that tell us about grid cells?
Term
They work together to keep track of where we are. The place cells are a mechanism for keeping track of where we are. The place cells keep track of where we are by coding for our precise location and the grid cell updates the location. (Like one cell telling us we're facing forward and the other tells us when we're approaching a boundary).
Definition
How do grid cells and place cells work together?
Term
entorhinal region
Definition
Where are grid cells located?
Term
CT scan and MRI
Definition
What two imaging techniques are good for structural imaging?
Term
MRI higher res
Definition
which has a higher resolution imaging, CT scan or MRI?
Term
higher res, no ionizing radiation, better spacial res (identifies individual structures and folds of gyri), better discrimination between white matter and gray matter, adapted for use in fMRI
Definition
advantages of MRI over CT?
Term
PET scans and fMRI
Definition
These two imaging techniques are good for seeing brain activity
Term
PET scans
Definition
What imaging technique uses radioactive glucose that is injected into the bloodstream and followed through the brain as it they puts off radioactive emissions and flows to places where the brain is most active while a participant performs a particular task or takes a particular test?
Term
fMRI
Definition
this imaging technique measures change from oxygenated to deoxygenated blood, which is used to infer activity in a particular region.
Term
brain activations are presented graphically by color coding the strength of activation across the brain or specific region being studied. temporal resolution: results take a few seconds so we may not see the first place that brain activity happens in
Definition
how is the brain activity presented in fMRI? how's the temporal resolution in an fMRI?
Term
PET measures bloodflow to a particular region in the brain, fMRI measures blood oxygenation.
Definition
Simply contrast fMRI and PET scan as it relates to what they measure
Term
PET scans, radioactively label the drug
Definition
What kind of imaging technique would be used to follow a drug and show what part of the brain reacts to the drug and affects it?
Term
The signal for satiation doesn't happen.. keep eating and eating and eating
Definition
What happens if you lesion the ventromedial hypothalamus?
Term
inactivation
Definition
What's the purpose of lesioning part of the brain
Term
it can establish causal links
Definition
Good thing about lesioning parts of brain? (from an experimental standpoint)
Term
Transcranial Magnetic Stimulation
Definition
In this experimental measure, a coil with an electric current is applied to the scalp which can be used to cause reversible inactivation (via virtual lesioning) or activation.
Term
can't activate or inactivate structures deep within the brain because the current from the coil only gets just below the surface.
Definition
Problem with TMS?
Term
Optogenetics
Definition
This sort of experiment technique modulates activity of neurons by using light.
Term
Light sensitive proteins form algae ar einserted into brain and the brain will respond in the same way... ion channel opens up to blue light because algae opens up to blue light.
Definition
How does optogenetics work?
Term
improving memory
Definition
What is a good thing TMS has been used for?
Term
sexual differentiation
Definition
the process by which individuals develop male or female bodies and behaviors that happens during prenatal development
Term
organizational period
Definition
_______ ________ influence structure of the way the brain and body is being wired together; it's permanent and occurs during the sensitive period (neonatal).
Term
allomone
Definition
chemicals released outside of the body to affect individuals of another species
Term
pheromones
Definition
chemicals released outside the body to affect other individuals of the same species
Term
genital tubercle
Definition
this part of the fetus can develop into male or female organs externally
Term
indifferent gonads
Definition
precursors to either testes or ovaries, they can become either depending on certain hormones.
Term
wolffian ducts
Definition
can form male internal organs (epididymis, vas deferens, and seminal vesicles)
Term
mullerian ducts
Definition
can form female internal organs
Term
SRY gene
Definition
At 8 weeks this becomes activated, once activated it sends a signal to the indifferent gonads to become testes
Term
Anti-mullerian hormone (AMH)
Definition
this hormone works to defeminize the organs
Term
5alpha-reductase
Definition
_________________ is an enzyme that converts testosterone into the more powerful dihydrotestosterone (DHT) which is necessary to form external male genitalia
Term
Congenital Adrenal Hyperplasia (CAH)
Definition
in this instane, the adrenal glands produce excessive adrenal hormone prenatally which exposes female to androgens before birth. When this happens, a masculization of the phenotype occurs resulting in possible interest appearance. No testes are present but the ovaries are normal, despite appearance of external genitalia. may have some remnants of wolffian system
Term
Androgen insensitivity syndrome (AIS)
Definition
When this occurs in a woman, external tissues develop mainly as female but a uterus isn't formed so they can't have children, testes are internal and breast development at puberty occurs.
Term
Turner's syndrome
Definition
occurs when individual has only one chromosome, a single X. Individual develops as female but has traits characteristic of this condition. The female is also hyperfeminine.
Term
prenatally all initial steps are male but a penis doesn't develop until puberty when there is a big rush of testosterone.
Definition
What happens in 5 Alpha-reductase deficiency?
Term
Sexually dimorphic nucleus of the POA (SDN-POA)
Definition
__________________ is a region of the brain that is typically larger in males than females.
Term
"distant father; over-attachment and identification with mother. happens from unresolved conflicts (namely, unresolved Oedipus complex).
Definition
What is the Freudian view of homosexuality?
Term
Baby is sexually neutral at birth, "homosexuality is a result of improper interactions with parents or faulty learning"
Definition
Implications of social constructivist view of sexual orientation?
Term
children of lesbian parents generally are hetero despite predictions that orientation is learned
Definition
What refutes social constructivism?
Term
Androgenic Insensitivity syndrome (AIS)
Definition
In this case, a person identifies as female, they have an XY genotype but they aren't receptive to testosterone, they're attracted to males.
Term
the 2D-4D ration, oto-acoustic emissions, and INAH-3 larger
Definition
What are some markers for pre-natal testosterone?
Term
John Money shitty guy
Definition
the social constructivist that fucked up Brenda/Bruce but the experiment was claimed "successful"
Term
mother's
Definition
Sexual orientation seems to be inherited from which side?
Term
Xq28, Hamer
Definition
Gay brothers are likely to share a marker located on the long arm of the X chromosome called ________. who discovered this?
Term
female-typical behavior patterns with possible altered genital development
Definition
effect prenatal stress can have on male mice
Term
assymetrical
Definition
The corpus callosum is more ______ in subjects with high fetal testosterone
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