Term
tyrosine kinase transfer phosphate from _ to a trysoinse reside |
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Definition
ATP (why called phosphylation) |
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Term
tysonie kinases belong to a bigger class called |
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Definition
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Term
phos/dephos is important fro signal trnasduciton leading to cancer |
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Definition
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Term
4 bad things that lead to too much tyrosine kinase activaiotn |
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Definition
genetic alteration, gene amp, point mutation, protein accum |
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Term
what TKIs target BCR;ABL / CML first line-1 second line -3 |
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Definition
imatinib nilotninb, dasatonib, bosutinib |
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Term
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Definition
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Term
CYP 3A$ inhibots that increase imatinib conc-4 |
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Definition
ketoconazole, itraocnazle, erthomycin, clarithromycin |
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Term
3A4 induces that decrease imintib-4 |
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Definition
phenyotin, carbmezapine, st johns wort, dexmethasone |
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Term
counsel to take imatinib wiht-2 |
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Definition
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Term
imatinib increases systemic conoc of- |
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Definition
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Term
imatinib pts should recieve what type fo anticoag/ |
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Definition
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Term
severe ADEs fo imitiniab-4 |
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Definition
hemorrhage, heptox, heme tox, CHF |
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Term
when is nioltinib considered for CML |
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Definition
chronic or accel phases that failed imatinib |
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Term
what tests follow effiacy of nilotinib-2 |
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Definition
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Term
contraindicaiton for using nilotimib-3 |
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Definition
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Term
5 major drugs that have ineraction (3A4 inhibt) wiht nilotinib |
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Definition
amiodarone, dispoyramide, procainaimide, quindine, sotol |
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Term
pt wiht hisotry of _ dont use nilotinib |
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Definition
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Term
indicaiton for dasatinib-2 |
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Definition
chronic, aceel, blast pahse CML after imaitnib tx ALL resistant to imtinib |
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Term
what are the 4 drug classes dasintib cant be used with- |
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Definition
PPI/H2 anatg antacids 3a4 inhib 3a4 inducers |
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Term
TKIs that target EGFR/HER-2 |
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Definition
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Term
indications for erlotinib-2 |
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Definition
non small cell lung (after fail chemo) pancreatic |
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Term
erlotinib for pancreatic cancer needs to be combo with _ to be 1st line |
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Definition
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Term
cig smoking decrease conc of what drug |
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Definition
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Term
whcih drug has liver failr ADE |
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Definition
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Term
which drug has abnormal eyelash growth |
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Definition
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Term
whcih drug inhibits both HER-2 nad EGFR |
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Definition
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Term
Lapatinib should be given once daily for _ dyas, and capecitabine BID for _ days. cycle is _ days |
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Definition
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Term
common ADEs fo laptinib-2 |
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Definition
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Term
severe ADEs fo laptinib-3 |
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Definition
cardaic heptox intersti lung/pmneu |
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Term
TKIs that inhbit mult tyrosine kinases-3 |
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Definition
sunitinib sorafenib pazopanib |
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Term
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Definition
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Term
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Definition
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Term
counseling point for sorfenib |
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Definition
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Term
indicaitons for sorefanib-2 |
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Definition
RENAL carcinoma hepat cell |
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Term
even tho has a lot fo interacitons with drugs, wiht most anti neoplastics sorafenib works well |
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Definition
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Term
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Definition
hand foot alopecia wound healing |
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