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Exam 2
Lecture 9- tyroskine kinase inhibitors
36
Architecture
9th Grade
02/11/2014

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Term
tyrosine kinase transfer phosphate from _ to a trysoinse reside
Definition
ATP (why called phosphylation)
Term
tysonie kinases belong to a bigger class called
Definition
protein kinases
Term
phos/dephos is important fro signal trnasduciton leading to cancer
Definition
phosphyrlation
Term
4 bad things that lead to too much tyrosine kinase activaiotn
Definition
genetic alteration, gene amp, point mutation, protein accum
Term
what TKIs target BCR;ABL / CML
first line-1
second line -3
Definition
imatinib
nilotninb, dasatonib, bosutinib
Term
imatinib is metb by
Definition
CYP3A4
Term
CYP 3A$ inhibots that increase imatinib conc-4
Definition
ketoconazole, itraocnazle, erthomycin, clarithromycin
Term
3A4 induces that decrease imintib-4
Definition
phenyotin, carbmezapine, st johns wort, dexmethasone
Term
counsel to take imatinib wiht-2
Definition
meal
glas sof waeter
Term
imatinib increases systemic conoc of-
Definition
APAP
Term
imatinib pts should recieve what type fo anticoag/
Definition
heparin
Term
severe ADEs fo imitiniab-4
Definition
hemorrhage, heptox, heme tox, CHF
Term
when is nioltinib considered for CML
Definition
chronic or accel phases that failed imatinib
Term
what tests follow effiacy of nilotinib-2
Definition
heme
cytogeneic
Term
contraindicaiton for using nilotimib-3
Definition
hypoMg, HypoK, long QT
Term
5 major drugs that have ineraction (3A4 inhibt) wiht nilotinib
Definition
amiodarone, dispoyramide, procainaimide, quindine, sotol
Term
pt wiht hisotry of _ dont use nilotinib
Definition
pancreatitis
Term
indicaiton for dasatinib-2
Definition
chronic, aceel, blast pahse CML after imaitnib tx
ALL resistant to imtinib
Term
what are the 4 drug classes dasintib cant be used with-
Definition
PPI/H2 anatg
antacids
3a4 inhib
3a4 inducers
Term
TKIs that target EGFR/HER-2
Definition
erlotinib
lapatinib
Term
indications for erlotinib-2
Definition
non small cell lung (after fail chemo)
pancreatic
Term
erlotinib for pancreatic cancer needs to be combo with _ to be 1st line
Definition
gemecitabine
Term
cig smoking decrease conc of what drug
Definition
erlotinib
Term
whcih drug has liver failr ADE
Definition
erlotinib
Term
which drug has abnormal eyelash growth
Definition
erlotinib
Term
whcih drug inhibits both HER-2 nad EGFR
Definition
lapaitnib
Term
Lapatinib should be given once daily for _ dyas, and capecitabine BID for _ days. cycle is _ days
Definition
21
14
Term
common ADEs fo laptinib-2
Definition
diarrhea
dermatologic
Term
severe ADEs fo laptinib-3
Definition
cardaic
heptox
intersti lung/pmneu
Term
TKIs that inhbit mult tyrosine kinases-3
Definition
sunitinib
sorafenib
pazopanib
Term
indications for sunitinb
Definition
GI tumor
renal carcinoma
Term
ADEs of sunintiib-3
Definition
N/V/D
Term
counseling point for sorfenib
Definition
dont take with food!
Term
indicaitons for sorefanib-2
Definition
RENAL carcinoma
hepat cell
Term
even tho has a lot fo interacitons with drugs, wiht most anti neoplastics sorafenib works well
Definition
Term
ADEs of sorafenib-3
Definition
hand foot
alopecia
wound healing
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