Term
| Dyssomnias is abnormalities in 3 things of sleep |
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Definition
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Term
| what are some dyssomnias?-4 |
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Definition
insomnia
narcolepsy
breathing related
restless leg |
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Term
| Parasomnia is abnormal what assoicated with sleep-2 |
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Definition
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Term
| what are examplesof parasomnia-3 |
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Definition
nightmare disodrer
sleep terror disorder
sleepwalking disorder |
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Term
| what % of population undergo insomnia |
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Definition
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Term
| what % of adults have chronic insomnia?what about elderly? |
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Definition
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Term
| what ppl are more likely to have insomnia?-3 |
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Definition
| widowed, unemplyed, lower eco status |
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Term
| insomnia is disorder characterized by what |
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Definition
| initating and maintaing sleep |
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Term
| look at slide 5 to see medical impact of insomnia |
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Definition
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Term
| after 24 hrs without sleep, the effects of sleep deprivation are like- |
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Definition
| acute alcohol intoxication |
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Term
| _ nights of ten hours of sleep equals total alertness |
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Definition
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Term
| moderate sleepiness is result of 2 tings- |
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Definition
anesthiology
4 nights of 6 hrs in bed |
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Term
| excessive daytime sleepiness is from what 2 things |
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Definition
narcolepsy
one night toal deprivaiton |
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Term
shorter/longer latency = sleepier person?
what duraiton = excessive sleepiness? |
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Definition
shorter
les than 5 minutes |
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Term
| how mnay americans have breathing sleep diorder |
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Definition
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Term
| sleep apnea is characterized by? |
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Definition
| breathing cessation followed by arousal to restart breathing |
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Term
| obstructive sleep apnea can be caused by?-2 |
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Definition
obesiy
anatomicla disorder |
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Term
centrally related sleep apnea is due to?
what can cause this? |
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Definition
CNS depression
CHF, advanced age |
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Term
| central sleep apnea occurs in what geneder and age mostly? |
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Definition
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Term
| what amnt of ppl have narcolepsy |
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Definition
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Term
| narcolepsy is chacrteized by-4 |
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Definition
sleep attacks
cataplexy
hallucinations
sleep paralysis |
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Term
what is may be the main cause of narcolepsy?
is it more or less in these pts? |
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Definition
orexin/hypocretin peptide system
undetectable |
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Term
| what disorder may be linked to HLA? |
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Definition
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Term
| what are the types of circadian rhythm disorder |
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Definition
advanced sleep phase
irregular sleep-wake
non 24 hr sleep wake |
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Term
| what is advanced sleep phase syndrome |
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Definition
| fall asleep early and wake early |
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Term
| what is irregular sleep wake type |
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Definition
| numerous naps, no main night sleep |
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Term
| what is non 24 hr sleep wake type |
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Definition
| abnormal synch of dark/light cycle and endogenous circadian rhytm |
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Term
| restless leg syndrome is more common in- |
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Definition
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Term
|
Definition
| unconfortable feelingsof muscles in legs or body with desire to move them |
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Term
| what may e causes of restless leg syndrome-2 |
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Definition
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Term
| what is the most common treatment for insomnia? |
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Definition
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Term
| what are the two groups of BDZs |
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Definition
traditional
non BDZ GABAa PAMs |
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Term
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Definition
| bind to GABA to cause hyperpolar neurons |
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Term
| traditoinal BDZ do what for sleep-2 |
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Definition
reduce latency
increase total sleep time |
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Term
| what can trad. BDZs not be combined with |
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Definition
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Term
| ADEs of traditional BDZs-3 |
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Definition
daytime sedation
rebound insomia
anteretrgorade amnesia |
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Term
| half life of trad BDZ is longer in what pts |
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Definition
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Term
| what are the traditional BDZs-4 |
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Definition
estrazolam
triazolam
temezepam
flurazapem |
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Term
| what are the non BDZ GABAa agonists-3 |
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Definition
zolpidem
zaleplon
eszopiclone |
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Term
| what do the non BDZ agonists not effect |
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Definition
| day psychomotr performance |
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Term
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Definition
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Term
| what BDZ class reduces ngihttime awakenings |
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Definition
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Term
| what are the ADEs of non BDZ agonists-3 |
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Definition
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Term
|
Definition
sleep eating
weight gain
sleepwalking/driving |
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Term
what are the OTC med class for sleep?
ewxamples?-2 |
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Definition
antihistamines
diphenhydramine, doxylamine |
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Term
| what are the antidepressants used for insomnia that have daytime sedation and bad side effects=3 |
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Definition
| amitriptyline, doxepin, nortrptyline |
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Term
| what are the antideprssents that dont affect day time sedaiton? |
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Definition
| mirtazapine, nefazadone, trazadone |
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Term
what is the melatonin recptor agonist for insomnia
how tolerated is it? what its funciton? |
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Definition
ramelteon
very well; induces sleep |
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Term
what is an herbal remedy for insomnia
whats is MOA? |
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Definition
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Term
what is therapy of choice for obsturctive sleep apnea?
what aare the 3 options of this? |
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Definition
non pharmcological
surgery, weight loss, PAP |
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Term
| what do ppl with obstructive sleep apnea need to avoid |
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Definition
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Term
| ppl being treated with PAP can take what med to increase daytime awakeness |
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Definition
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Term
| treatment for narcolespy falls into two categories of symtpoms- |
|
Definition
excessive daytime sleepiness
cataplexy |
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Term
| what are the drugs for exessive daytime sleepy?-3 |
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Definition
amphetamine
methamphet
mdafinil |
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Term
| what are some drugs for cataplexy-3 |
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Definition
fluoxetine
nortryiptyline
selegine |
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Term
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Definition
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Term
|
Definition
| headache, nausea, insomnia |
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Term
| why are antideprssants good for catalepsy |
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Definition
| block 5HT and NE reuptake to supress REM |
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Term
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Definition
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Term
| what is the MOA for sodium oxybate |
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Definition
| agonist for GABAb and GHB |
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Term
| how does sodium oxybate work- |
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Definition
increases REM
improves sleep |
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Term
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Definition
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Term
| primary therapies for restless leg syndrome-3 |
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Definition
DA agonists
iron replacemnet
Levodopa |
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Term
| what is the pearl to know about levodopa |
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Definition
| may just delay restless leg syndrome until later at night unless redosed |
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Term
| secondary therapy fro restless leg syndrome-3 |
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Definition
gabapentin
low potency opiates (codeine)
BDZs |
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Term
| when is gabapentin a good med to use for restless leg syndorem |
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Definition
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