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Exam 2
Lecture 5-Part 1
45
Architecture
9th Grade
03/16/2013

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Term
major cause of IHD
Definition
atherscelorsis
Term
has there been a decline or increase in deaths from IHD and why
Definition
decline
reduce risk factors and better treatment
Term
what can increase in angina without changing the blood vessels?
Definition
hypoxia
Term
hypoxia can be caused by-3
Definition
anemia
cyanotic heart disease
advaned lung disease
Term
MVO2 (demand) can increase due to what-5
Definition
BP, stress, HR, contraction, ionotropic
Term
the function of what 2 things determines the amount of O2 that blood can carry
Definition
-pulmonary
-hemoglobin
Term
adequate coronary blood flow is impacted grealty by?
Definition
athersclerosis
Term
blood flow thru coronary artery is mainly during?
Definition
diastole
Term
PR and regulation is mainly at what type of vessels-2
Definition
small arterires
capillaries
Term
if no flow limiting atheroscelrotic blocks- which reistance is trivial?
Definition
R1
Term
coronary blood flow is regulated by heart's need of?
Definition
O2
Term
what is auto regulation
Definition
control of blood flow indepednetn of physiological alterations in BP
Term
metabolic regulation ex: 2
Definition
exercise, stress
Term
which vessels show the most ability for dilation
Definition
intramyocardial
Term
what % of stenosis is ok in the epicardial arteries?
Definition
50
Term
severity of ACS depdns on degree and location of
Definition
stenosis
Term
most common cause of MI
Definition
thombosis
Term
other casues of IHD -4
Definition
emboli
LVHT
BP decreases
anemia
Term
coronary artherosclerosis occurs mainly where- 2
Definition
increase turbulence
branchpoint of epicardial
Term
these factors disturb normal epitheliu-5m
Definition
smoking, high LDL, diabetes, HTN, low LDL
Term
_% stenosis keeps a good blod supply except when increased demand from exerrcise, etc
Definition
50
Term
_% stenosis is when blood flow is reduced even at rest
Definition
80
Term
do you want a slow or fast forming stenosis? why?
Definition
slow, have time to make collateral vessels
Term
stenosis of what 2 arteries are really bad
Definition
left main coronary
proximal left anterior descneding
Term
stenosis of an artery leads to dilation of-
Definition
distal resistance vessels
Term
effects of ischemia-5
Definition
hypokinesia, akinesia, dyskinesia, contractility, pump function
Term
acute ischemia causing failure of relaxation and constriciton presents as?
Definition
left ventricular failure
Term
for left ventricular failure, when do you have mitrial reguritation?
Definition
if papillary muscle is invovled
Term
trnasient ischemia presents as
Definition
angina pectoris
Term
prolonged ischemia presents as
Definition
acute MI
Term
ischemia effcts are reversible if shorter than how long
Definition
30 min
Term
when do myocytes start dieing during ischemia?
Definition
30 min
Term
ischmia causes a drop in this substance and a increase in-
Definition
ATP
lactate
Term
during ischemia does yourintracell pH increase or decrease?
this causes these ions to accumlate-2
this ion is kicked out
Definition
decreases
Na and Ca
K
Term
what is the prinicpal diagnostic tool for IHD
Definition
ECG
Term
if ischemia affects just a aprt of the artery thickness what happens to ST?
if affects whole thickness?
Definition
depression
elevation
Term
most patients who die suddenly of IHD is bc of
Definition
induced ventriclar tachyarrthymia
Term
do most ppl have symptoms of no symtpoms of IHD? why?
Definition
none
need 50% stenosis for symptoms
Term
heart failure is usually the result fo sympotamtic or non symptomatic IHD?
Definition
no symptoms
Term
CAD is classfied as what type of IHD
Definition
stable angina
Term
pathological Q waves- 4
Definition
>1 mm width
>2 mm deep
>25% depth of QRS
present in leads V-1-3
Term
STEMI or NSTEMI has more fo Q wave present?
Definition
STEMI
Term
Cad presents in men over- women over-
typical symtpoms:
Definition
50, 60
pressure, smothering, choking
Term
which type of angina is where the person puts a clenched fist over the sternum
Definition
stable/CAD
Term
where can CAD angina radiate at espeicaly-
Definition
ulnar surface of forearm and hand
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