Term
| when do you use gonadotpropins? |
|
Definition
|
|
Term
| wht are 3 negative points about gonadotropins |
|
Definition
expensive
parenteral daily
extensive monitoring |
|
|
Term
| what are the gonadoptropins -4 |
|
Definition
|
|
Term
| whatare the glycoproteins that make up pituitray hromones-4 |
|
Definition
|
|
Term
| structure of gonadotropins |
|
Definition
| glycosyltaed heterodimer- alpha and beta subunit |
|
|
Term
| gonadotropin in males does what |
|
Definition
|
|
Term
gonadotropin therapy in females does what
FSH-
LH |
|
Definition
maturation and devlopment of follicle
ovulation and corpeus luteum |
|
|
Term
| to use gonadoptropins in females the ovaries must be able to do what? |
|
Definition
|
|
Term
| route of admin for gonadoptropins (think proteins) |
|
Definition
|
|
Term
|
Definition
|
|
Term
| females use gonadotropin- 2 |
|
Definition
hypothalmic anovulation
ovulation for failed clomipehene |
|
|
Term
| what med do you use to stimulate the follicles for ART |
|
Definition
|
|
Term
| use of gonadoptropins in males |
|
Definition
| speratogensis with 1 or 2nd hyopgonadism |
|
|
Term
hCG would well in women infetile due to lack of?
how is it admin? |
|
Definition
midcycle gonadoptrin surge
IM |
|
|
Term
hCG activty is idneticle to?
which has longer half life? |
|
Definition
|
|
Term
|
Definition
| speratogensis with pituitary hypofunctino |
|
|
Term
|
Definition
| headache, fatigue, edema, gynectsomia, pain of injction |
|
|
Term
what are the hCG meds-
urine-2
r-hCH-1 |
|
Definition
|
|
Term
|
Definition
| supplements LH for LH surge |
|
|
Term
| female injects hCG- what is the rule for intercoiurse? |
|
Definition
| should have after injection and next 2 days |
|
|
Term
| hCG for males 2nd to hypogonadism |
|
Definition
| 100-200 2-3 x/week until normal testosteon |
|
|
Term
storage for the urine derived hCG?
for the r-hCG |
|
Definition
RT until mixed- then fridge
fridge until dispnesed to patient |
|
|
Term
| when do you use hCG in women-2 |
|
Definition
for ovulation WITH other agents
correct lack of mid cycle gonadotropin surge |
|
|
Term
what is the decapeptide rleased by the hypothalmus?
where does it go? |
|
Definition
GnRH
portal circulatory to pituitary |
|
|
Term
which is better for pituitary response-
pulistile or continuous GnRH |
|
Definition
|
|
Term
what is the GnRH med?
how is it admin? |
|
Definition
Gonadorelin/Lutrepulse
portable pump- IV or SQ |
|
|
Term
|
Definition
ovary hyperstimulation
multiple gestations |
|
|
Term
what does overstimulation ovary syndrome lead to?
what does VEGF have to do with it? |
|
Definition
cysyts
hyper permeable blood vessels- fluid from vasdcular comes to pleurual/abdominal |
|
|
Term
| GnRH agonists have longer/shorter half life than normal GnRH |
|
Definition
|
|
Term
| what two ways cna you give the GnRH agonists? |
|
Definition
trnasient
multiple formulation (short or long duration) |
|
|
Term
| what does trarnasient GnRH do? -2 |
|
Definition
down regulate GnRH recpotr
inhibit gonadotropin secretino |
|
|
Term
| multiple formulaitons of GnRH agonits are used to do what? |
|
Definition
decreased number of oocytes release prematurely
improve oocyte leading |
|
|
Term
| pulsitiel delivery of GnRH agonsits stimulates what? |
|
Definition
| gonadotropin release from pituitary |
|
|
Term
| continuous delivery of GnRH does what for gonadoptropin relasE? |
|
Definition
| increae for a while- but then shuts it down |
|
|
Term
|
Definition
excess ovary stimulation
excess estrogen- breast tedner, vaginal bleeding
estrogen deficiency- hotflashes, headache |
|
|
Term
| what are the suffix fr GnRH agonists |
|
Definition
|
|
Term
what is the long term GnRH therapy for?
short term? |
|
Definition
|
|
Term
for long term therapy of GnRH-
when was it started? how often dosed?
wht does it do the pituitary? |
|
Definition
previous cycle; continuous
suppresses |
|
|
Term
for short term doese of GnRH:
when do you start GnRH?
when do you start the gonadoptropins? |
|
Definition
day 2 of cycle
day 3 of cycle |
|
|
Term
| what is the suffix of GnRH antagonists |
|
Definition
|
|
Term
when do you recieve GnRH antagonists?
what does it do? |
|
Definition
| those on ovarian hyperstimulants- prevents premature LH surge and premature ovulation |
|
|
Term
GnRH antagonists suppress what?
what do they not have that GnRH do? |
|
Definition
LH surge
initial flare of secretion |
|
|
Term
how are GnRH antagonists administered?
bioavaialble? |
|
Definition
|
|
Term
| storage of GnRH antagonists |
|
Definition
|
|
Term
| what are teh 2 GnRH antagonists (brand names) |
|
Definition
|
|
Term
| ADEs of GnRH antagonists -4 |
|
Definition
| Ovrian hyperstimulate, vaginal bleeding, N/V |
|
|
Term
|
Definition
metformin
progestins
estrogen
guanfenisen
dopamine agonists
Low Dose Aspirin |
|
|
