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Exam 1 review
chapter 1,2,3,5,8
99
Physiology
Undergraduate 2
09/23/2012

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Cards

Term
True or false
Endocrine and exocrine glands are derived from epithelial tissue?
Definition
True
Term
True or false
Exocrine glans includes ducts for the creted product to enter the blood?
Definition
False
Term
True or false
A CHANGE IN THE MEMBRANCE FROM -110Mv TO -70Mv IS CALLED HYPERPOLARIZATION.
Definition
False
Term
True or false
A change in membrane potiental from -50mV to-70mV is called repolarization
Definition
True
Term
True or false
Opening calcium channels will cause membrane potiental to depolarize. Assume the cell is starting at the resting membrane potiental
Definition
True
Term
True or false
Closing potassium channels will cause membrane potiental to depolarize. Assume the cell is starting at the resting membrane potiental
Definition
True
Term
True or false
Closing sodium channels will cause the membrane potiental to hyperpolarize. Assume the cell is starting at the resting membrane potiental.
Definition
True
Term
True or false
A decrease in extracellular K+ will result in decreased neuronal excitability
Definition
True
Term
True or false
All neurons are myelinated
Definition
False
Term
True or false
Voltage gated K+ channels are involved in stimulating insulin release by beta cells when extracellular glucose levels are high
Definition
False
Term
True or false
Entrance of Calcium into the synaptic terminal is what causes exocytosis of neurotransmitter
Definition
Tue
Term
True or false
Secondary active transporters can be uniporters
Definition
False
Term
True or false
Transporters of glucose into the cell by the GLUT transporter would be reduced in the presence of galactose?
Definition
True
Term
True or false
The acetylcholine receptor found on the cell body of neurons is an example of a ligand gated channel?
Definition
True
Term
Describe homeostatis and how it is maintained.
Definition
Homeostatis: How the bosy maintains a relatively stable internal enviroment despite changes in the external enviroment.
1). Change in external enviroment->receptors->afferent pathways->nervous systems->efferent pathways->effectors->reponse
2). Change in external enviroment_>receptors->endocrine system (Hormones)-> efferent pathway->effectors->response
Term
Which of the following transporters require the use of energy?
Na+/K+ Pump
GLUT transporter
Na+/Glucose symporter
Oxygen diffusion
Definition
Na+/K+ pump
Na+/Glucose Symporter
Term
Which could allow a cell to accumulate a high concentration of a substance intracellularly?
Definition
endocytosis
secondary active transport
Term
what would result in a decrease in simple diffusion of molecule X?
Definition
increasing the thickness of the membrane
Term
true regarding ion channels?
Definition
they open and close as a result of conformational changes of a membrane protein.
Term
Which of the following cations are found in HIGHER concentrations OUTSIDE the cell versus inside?
K+
HCO-3
NA+
Ca2+
Cl-
Definition
Na+
Ca2+
Term
List 2 IV solutions that are isotonic?
Definition
0.9% saline
5% dextrose in 0.9% saline
Term
List IV solutions that would result in an increase in intracellular volume? (hypotonic)
Definition
5% dextrose in 0.45% saline
D5W
0.45% saline
Term
Can a solution be both isosmotic and hypertonic?
Definition
NO
Term
What is the normal range of extracellular osmolarity. Include units
Definition
280-296 mOSM
Term
Assume a cell has a membrane potiental of +25 mV, what direction (into or out of the cell) is the electrical gradient for K+?
Definition
out of cell
Term
Assume a cell has a membrane potiental of +25 mV, what direction (into or out of the cell) is the chemical gradient for K+ (concentration)
Definition
out of cell
Term
define resting membrane potiental?
Definition
When a cell is at rest the difference in electric charge between inside and outside of the cell is a source of potiental energy (Non active)
Term
How do you know that someone has tapped your shoulder lightly compared to when they punch you in the shoulder?
Definition
If the graded potiental is larger then the membrane will be at or above threshold for longer allowing for more action potientals to be producing thus allowing more neurotransmitters to be released.
Term
What is the homestatic range for plasma pH?
Definition
7.35 -7.45
Term
Name a specific location in the body that has a more acidic pH than plasma. Name it and give the specific pH?
Definition
Salvia 6.5
Term
What is the plasma concentration of Ca2+?
Definition
1mM
Term
When a neuron is at rest give some true statements?
Definition
The activation gate of the voltage-gated Na+ channel is closed.
The inactivation gate of the voltage-gated Na+ channel is open.
The membrane is more permeable to K+ channel is closed
Non-gated K+ channels are open.
Term
Which type of epithelial tissue would you find in the digestive tract?
Definition
Simple columnar
Transporting epithelia
Term
Functions of the membrane proteins?
Definition
receptors for neurotransmitters
form ion channels
participate in cell to cell junctions'
Term
WHich of the following events are occuring during a relative refactory period?

A. Voltage gated Na+ channels are opening
B. Voltage -gated K+ channels are open
Definition
voltage -gated K+ channels are open
Term
What is lipoprotein function?
Definition
lipoprotein transports cholesterol and triglycerides
Term
What is the function of cholesterol
Definition
building block for production of cortisol and is a component of membranes
Term
Which of the following are correct regarding cell-cell junctions?
___tight junctions are formed by cadherin and prevent movement of substances between adjacent cells
___adherens junctions are strong and connect the actin cytoskelton between adjacent cells.
___gap junctions allow for substances pass between the cytoplasm of adjacent cells through connexin channels
___both tight and adherns junctions are found among transporting epithelia
Definition
___adherens junctions are strong and connect the actin cytoskelton between adjacent cells.
___gap junctions allow for substances pass between the cytoplasm of adjacent cells through connexin channels
___both tight and adherns junctions are found among transporting epithelia
Term
what is the function of microvilli?
Definition
increase surface area for absorption
Term
this muscle is both non-striated and involuntary
Definition
smooth muscle
Term
This cell type of connective tissue produces the matrix of connective tissue
Definition
fibroblasts
Term
what is one feature and facilitated diffusion have in common?
Definition
spontaneous they don't require energy
Term
what are two features that distinguish facilitated diffusion from simple diffusion?
Definition
Simple-no protein/facilitated uses a protein.

simple -more concentrated, more rate of absorption. Facilitated rate will
Term
A solution that contains 100mM CaCl2 and 150mM Glucose is considered_______osomotic and ______tonic?
Definition
hyper/iso
Term
What body fluid compartments contain the least amount of proteins?
Definition
interstitial
Term
what body fluid compartments contain the most water
Definition
intracellular fluid
Term
what is the normal range for body osmolarity?
Definition
280-296 mO5M
Term
what factors dictate whether a substance can undergo simple diffussion?
Definition
membrane surface area is larger
membrane is thinner
molecules size
Term
true or False

The body is in osmotic equilibrium
Definition
true
Term
name two mechanisms that are utilized to gate ion channels
Definition
voltage gate/ligand gate
Term
Name a secondary active antiporter
Definition
Na+/Ca2+ pump
Term
name another type of glial cell and indicate one role it plays in the body
Definition
oligodendrocytes-produces myelin in the centeral nervous system.
Term
this is the type of glial cell that produces myelin in the peripheral nervous system
Definition
schwann cells
Term
true or False
water content of the body increases with age
Definition
false
Term
true or False
a solution that is hyposmotic solution can be hypotonic
Definition
true
Term
true or False
all cells in the body have a resting membrane potiental and can change their membrane potiental in response to signals
Definition
true
Term
true or False
changing the extracellular Na+ concentration (beyond the homostatic window) will cause resting membrane potiental to change
Definition
true
Term
true or False
all connective tissue is composed of cells, fibers and ground substance
Definition
true
Term
describe characteristics of action potentials
Definition
Due to the opening of ion channels

Can be carried over long distances
Term
describe graded potientals
Definition
Can be summed.
Can be produced by all cells.
Due to the opening of ion channels.
No minimum required to intiate.
Are produced in cell bodies of neurons
Term
Sopie has lost 7.5 pounds due to a prolonged period of vomiting and diarrhea due to influenza. How much fluid would she need to recieve to replace the fluid lost from this illness? assume all weight lost is due to water.
Definition
3.4 L
(7.5lbs/1) (1kg/2.2 lbs) (1L/1kg)=3.4 L
Term
In which situation (A or B) would you get a greater net Na+ movement through an open channel?
a. Membrane potiental is -30mV
B. membrane potiental is +20mV
Definition
A-membrane potiental is -30mV
Term
Name one function of a integral membrane protein
Definition
Act as a channel to allow substances (ions) to pass through
Term
Name another funtion of an integral membrane protein
Definition
bind cell to adjacent cell by connecting to other proteins
Term
this organelle is found in muscle cells and stores calcium
Definition
sarcoplasmic reticulum
Term
these are the proteins that form tight junctions
Definition
claudin and occludin
Term
This is the name of the region of the plasma membrane that faces the lumen of an organ (ex. the lumen of the intestine)
Definition
apical surface
Term
This type of cell-cell junction is formed by both transmembrane and peripheral membrane proteins
Definition
adherins junction
Term
this type of cell-cell junction is found in cardiac muscle
Definition
Gap junction
Term
transporting epithelia is a specific type of epithelial tissue
Definition
simple columar epithelial tissue
Term
name two locations in the body where you would find exchange epithelia.
Definition
lungs and blood vessels
Term
exchange epithelial is this specific type of epithelial tissue
Definition
simple squamous epithelial tissue
Term
these structures which are extensions of the plasma membrane increase the surface area of the cell that is exposed to the external enviroment
Definition
microvilli
Term
this is the type of epithelial tissue found lining the airways in the respiratory system
Definition
pseudostratified cilliated columnar epithelial tissue
Term
what is one difference between exocrine and endocrine glands?
Definition
exocrine uses ducts and endocrine does not.
Term
this is the type of cell that produces the matrix of connective tissue
Definition
fibroblasts
Term
other than cells, what are the other components found in all types of connective tissue?
Definition
ground substance and fibers
Term
what type of muscle is both striated and involuntary
Definition
cardiac muscle
Term
name 2 specific types of connective tissue whrite both answers on the same line.
Definition
adipose and bone
Term
what is one difference between simple and facilitated diffusion
Definition
the higher the concentration of a molecule the more simple diffusion will occur but facilitated will eventuallu plateau
Term
what body fluid compartment contains the most large anions and proteins
Definition
intracellular fluid
Term
what body fluid compartment normally contains no large anions or proteins
Definition
interstitual fluid
Term
name two substances that cross the membrane by simple diffusion
Definition
oxygen and carbon dioxide
Term
this type of glial cell produces myelin in the centeral nervous system
Definition
oligodendrocytes
Term
for each ion indicate where it is higher concentration (either inside or outside of cell) where it is higher concentration
A. HCO3-
B. Na+
C. K+
D. Cl-
Definition
A. HCO3--Interstical
B. Na+ Intersticial
C. K+ Intracellular
d. CL- Interstical
Term
The cell is moving K+ from inside of the cell to outside the cell. Could the transport of K+ in this direction be occuring simple diffusion
Definition
No-
equines a protein
Term
name a specific secondary active symporter
Definition
Na+/Glucose pump
Term
Name a specific primary active uniporter
Definition
Ca2+ pump
Term
Name a specific facilitated transsporter
Definition
GluT transporter
Term
what is a similarity between primary and secondary active transport
Definition
energy is needed
Term
true/ false

The body is osmotic and chemical equilibrium
Definition
False
Term
True and False

The body is in electical equilibrium
Definition
false
Term
what body fluid compartment contains the most water
Definition
intercellular fluid
Term
Name a specific intravenous solution that is both hyperosmotic and hypotonic
Definition
D5 1/2 normal saline
Term
name a specific intravenous solution that is both hyperosmotic and isotonic
Definition
D5 normal saline
Term
name a specific cell type that good at performing phagocytosis
Definition
macrophages
Term
what is the equilibrium potiental for an ion which a=has extracellular concentration of 74 mM, intracellular concentrations of 148 mM and a charge of +2
Definition
-9.2 mV

Work: 61/2log {74}/{48}
Term
other than that they can be gated, name another property of ion channels
Definition
They can be gated, name another property of ion channels
Term
acetylcholine binds to a receptor which opens an ion channel. What mechanism of ion channel gating is described in this situation.
Definition
ligand-gated ion channel
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