Term
is this cell cycel specifc or non specifc:
antimetabolites (methotrexate) |
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Definition
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Term
is this cell cycle specifc or non specifc:
antibitoics (belomycin) |
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Definition
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Term
is this cell cycle specifc or non specifc:
txanae (paclitaxel) |
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Definition
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Term
is this cell cycle specifc or non specifc:
epipodophys |
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Definition
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Term
is this cell cycle specifc or non specifc:
vinca alkaloids |
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Definition
| is this cell cycle specifc or non specifc: |
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Term
| Cell cycle specifc drugs wokr mainly on what cells |
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Definition
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Term
| cell cycle specific drugs work best on what cancers-2 |
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Definition
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Term
is this cell cycle specifc or non specifc:
alkylating agents |
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Definition
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Term
is this cell cycle specifc or non specifc:
anticancer antibitoics |
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Definition
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Term
is this cell cycle specifc or non specifc:
camptothecins |
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Definition
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Term
is this cell cycle specifc or non specifc:
metals |
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Definition
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Term
| cell cycle non specific drugs work on what cells? |
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Definition
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Term
which drugs work on BOTH high or low growth factor?
which is only for high? |
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Definition
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Term
| * CCS only wokr on some cell cycle phases, they are? |
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Definition
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Term
| what are the 3 targets of anti cancer drugs |
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Definition
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Term
what are cells that are normally fast dividing?-4
*anticancer drugs can attack these too* |
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Definition
| bone marrow, hair follicle,s gut epitheial, sperm forming |
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Term
| Chemo drugs are more potent to high or low growth fraciton? |
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Definition
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Term
| why are proliferating cells more sensitive to chemo drugs? |
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Definition
| these drugs disprutp mitotis or DNA synth |
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Term
| slide 40 has all the toxicites chemo cna cause ot the body |
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Definition
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Term
| damage to what by anticancer drugs is the main cause of marrow toxicity |
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Definition
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Term
| slide 42 has all the drug resistance pathways |
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Definition
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Term
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Definition
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Term
*diff genes must be altered in diff tissue to get cancer.
APC=colon for ex. |
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Definition
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Term
| tumor supporessor genes code for- |
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Definition
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Term
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Definition
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Term
| * benging resemble orginal cells and don't recur after surgeyry |
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Definition
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Term
* malignant cancers:
-leukemia, lympha, blastoma, |
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Definition
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Term
what type of malignant cancer makes up 90%
what is its origin |
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Definition
carncinoma
epithelil (skin, organ, glands) |
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Term
| whcih malignnant cancer is of connective tissue? |
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Definition
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Term
| what is the leading cause of deaht in both male aand female pts with cancer? |
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Definition
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Term
poor/well differentiated cancers are more drug resist
why? |
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Definition
poor differentiated
genetic mutation made it too diff of morphology |
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Term
| Gompertzian growth curve shows that cancer is _ growth |
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Definition
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Term
| at what size is cancer detectable on gompterzian scale |
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Definition
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Term
| the gompterzian scale shows that with time _ increases and _ decreases |
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Definition
doubling time
growth fraction |
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Term
| tumor growth fraciton is: |
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Definition
| prloferating: resting cells |
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Term
| tissue in G0 has what kind of growth fraction? |
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Definition
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|
Term
doubling time for a soldi tumor?
(double time is time for tumor to double in size) |
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Definition
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|
Term
doubling time for breast cancer
for lymph/leuk |
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Definition
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|
Term
| *doubling times diff in subcategoires of specific cancers *look at alide 17 |
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Definition
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Term
| methods for cancer to spread (metastasis)-4 |
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Definition
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|
Term
| after removing rpimary tumor, where does recurring cancer normally go? |
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Definition
| distant site. ex: leukemia |
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Term
| metastaic pattern varies with tumor* |
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Definition
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|
Term
| what are common sites fo metastasis-7 |
|
Definition
| liver, lung, lymph, bone, brain, skin, adrenal |
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|
Term
T0 means
T1-3 means?
T4 menas |
|
Definition
carcnimoa insitu
larger size
spread to another organ |
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Term
| N in staging of cancer means? |
|
Definition
| spread extenet to lymph nodes |
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|
Term
| what does an X mean if given in staging of cancer? |
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Definition
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|
Term
| Duke's grading scale is for what cancer? |
|
Definition
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|
Term
| Gleason grading scale is for what cancer |
|
Definition
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|
Term
| Epsteien Barr virus causes what cnacers-2 |
|
Definition
nasopharyngeal
Burkitt's lymphoma |
|
|
Term
| 2 viruses that can cause cancer |
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Definition
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|
Term
| Chemo has _ log kill and _ regrowth |
|
Definition
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|
Term
| factros that influence survival rate?-3 |
|
Definition
nature of cancer
pt
pharmacology |
|
|
Term
| what terminology only applies to leukemia? |
|
Definition
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|
Term
Def:
induce remission in leukemia |
|
Definition
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|
Term
Def:
given after remission to maintain leukemia remission |
|
Definition
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|
Term
def :
GIVEN BEFORE PRIMARY THERAPY TO ASSIST (INTENT TO SHRINK CANCEr) |
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Definition
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|
Term
def:
lowest point for hematopoeitc cells |
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Definition
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|
Term
| majority of cancer chemof ro currative or pallatative pruposes? |
|
Definition
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|
Term
| is chemo used more on its own or with other meds |
|
Definition
|
|
Term
| what 3 cancers does chemo not work for |
|
Definition
malignant myleoma
pancreatic cancer
renal cancer |
|
|
Term
| what stage is cell division |
|
Definition
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