Term
hemodynamic mediated renal failure is due to decreased-
this causes insufficiecnt pressure to miantain? |
|
Definition
blood flow to glomeruli
filtration across capillaries |
|
|
Term
if one has decreased pressure in afferent arteriole- cause release of
and synth of?
this causes constriciton of hwat arteriole?
incr or decr GFR?
does this help or harm hemodynamics? |
|
Definition
renin
ANG II
efferent
incr GFR
helps! get more cpaillary trnasport |
|
|
Term
what drug classes block the renin angiontensin system?
what does this reduce? |
|
Definition
ACEI
ARBS
ability to increase hydrostatic pressure for capillary exchange (decreases GFR, leads to renal failure) |
|
|
Term
how do you prevent nephortoxicity due to:
large drug exposure due to large RBF -2 |
|
Definition
1- avoid systemic admin
2- limit total dose |
|
|
Term
how do you prevent nephortoxicity due to:
renal hemodynamics |
|
Definition
| avoid inhibitors of prostaglandins |
|
|
Term
how do you prevent nephortoxicity due to:
drug accumulation |
|
Definition
|
|
Term
how do you prevent nephortoxicity due to:
increase energy requirements |
|
Definition
| decrease energy demand by decrease cell membrane transport |
|
|
Term
how do you prevent nephortoxicity due to:
conentration of drug in lumen -2 |
|
Definition
prevent dehydration (less water reabsorbed then)
-use diureis to increase water flow |
|
|
Term
how do you prevent nephortoxicity due to:
precipitaiton of drug in acidic urine - |
|
Definition
|
|
Term
how do you prevent nephortoxicity due to:
compensatory mechanism? |
|
Definition
| avoid drug use in renal failure ppl |
|
|
Term
| why do you want to avoid inhibiting prostoglandins--2 |
|
Definition
they are vasodilators
in decreased RBF they protect from ischemia |
|
|
Term
| admin of NSAIDS during renal ischemia promotes- |
|
Definition
antiprostoglandins (antivasodilate)
-increases ischemia/ less GFR |
|
|
Term
| who are the ppl at greatest risk of NSAID nephrotox? |
|
Definition
| those with preexisting renal insuffiency |
|
|
Term
what to avoid co adminster of NSAID and-2
why |
|
Definition
ACEI and ARB
dramtic decrease in pressure |
|
|
Term
| what 2 immunosuppressive drugs have dose limiting toxicity due to hemodynamic changes |
|
Definition
|
|
Term
cyclosporin and tacrolimus increase what vasoconstrictors -3
what vasodilators do they decrease? |
|
Definition
Tx A2, endothelin, ang II
NO, Prsotacyclin, porstaglandin E2 |
|
|
Term
| systmic ployarteritis nododsa is caused by what drugs |
|
Definition
|
|
Term
| thrombus formation can be caused by? -5 |
|
Definition
oral contraceptives
cyclosporin
mitomycin
cisplatin
quinine |
|
|
Term
| what drugs can cause embolis of cholesterol-2 |
|
Definition
|
|
Term
minimal change glomerular disease can be caused by?
how? |
|
Definition
NSAIDS
induce T cell infiltrates which release lymphokines which increase perrmability to proteins |
|
|
Term
| Focal seg Glomeruoscerlosis is charcterized by what 2 things |
|
Definition
pathy scerlosis
intersitial inflammation |
|
|
Term
causes of focal seg. glomerulosclerosis:
which drug?
which diseasE? |
|
Definition
|
|
Term
| what is the most common drug induced glomerular lesion? |
|
Definition
|
|
Term
what drug causes membrane nephropathy-
which causes it more the oral or parenterol? |
|
Definition
|
|
Term
What is teh most common mechanism of DIKD
what drugs cause this? -3 |
|
Definition
acute tubular necrosis
aminoglycosides
cyclopsorin
radiographic contrast media |
|
|
Term
primary target of aminoglycoside toxciity is-
this causes a _ that leads to backleak.
what is something they casue to accumulate? |
|
Definition
proximal tubule epithelial
obstruction
phospholipids |
|
|
Term
| toxicity of aminoglycosides is proportional to their |
|
Definition
|
|
Term
| what is one of the common causes of hospital aqcuired renal failure? |
|
Definition
|
|
Term
| the renal patholgoy of allergic interstitial nephritis is the accumulation of what cells- 4 |
|
Definition
lymphocytes
plsama cells
eoisinophils
PMN neutropils |
|
|
Term
| what 2 drugs can cause allergic interstitial nephritis |
|
Definition
|
|
Term
| this drugs causes chronic interstitial nephritis |
|
Definition
|
|
Term
| what is a risk of using cyclosporin and tacrolimus in cardiac transplant ppl |
|
Definition
| ability to cause intersitial fibrosis 6-12 mo after therapy |
|
|
Term
| what drug can cause obstricutive nephropathy due to precipitation |
|
Definition
|
|
Term
| what renal disease does acute uric acid nephropathy induce? |
|
Definition
|
|
Term
you can lessen uric acid accumulation with what techniques?
with what drug? |
|
Definition
alkalinization or hydration
allopurinol |
|
|
Term
| obstruction caused by prostate hypertrophy can be caused by? |
|
Definition
|
|
Term
| obstruciton caused by bladder fibrosis can be caused by: 2 |
|
Definition
cyclophosphamide
isofamide |
|
|
Term
nephrolithiasis is-
what meds can cause this-2 |
|
Definition
kidney stones
trimaterene-HCTZ
Laxatives |
|
|
