Term
| cadiac output depeddns on |
|
Definition
miocardioal contractility
ventricular filling pressure |
|
|
Term
| 3 functions of the kidney |
|
Definition
filtration
reabsoprtion
secretion/excretion |
|
|
Term
| normla urine production rate is |
|
Definition
|
|
Term
| what makes up the nephron- 2 |
|
Definition
|
|
Term
| are the capillaries in the glomerulus tight? |
|
Definition
|
|
Term
reabsoorption in the kindey is greatest where?
wht is second best? |
|
Definition
proximal tubule
loop of henle |
|
|
Term
what is termed the inside of proximal tubule?
outside?
whihc has the filtrate? |
|
Definition
lumen
parenchyma/interstial fluid
lumen |
|
|
Term
| where is urea imperrmeable? |
|
Definition
| distal tubule an collecting duct |
|
|
Term
in late distal tubule and collecting duct:
NA reabsorp is controlled by?
H20 reaborp is controlled by? |
|
Definition
|
|
Term
| chronic use of diuretic causes net _ of NA,which initiates what? |
|
Definition
deficit
compensatory mechanisms |
|
|
Term
chronic effect of diuretic?
how? |
|
Definition
|
|
Term
| where do loop diuretics work- specifcically where on the loop of henle |
|
Definition
|
|
Term
what does loop diuretic inhibit directly?
what about indirectly? |
|
Definition
Na/K/CL2 symporter;
Mg and Ca reabsorption |
|
|
Term
if use loop diuretics can cause direct excretion of-
indirect excretion of-
and if used acutely, excretion of- |
|
Definition
|
|
Term
| main uses of loop diuretics-5 |
|
Definition
-HTN
-hypercalcemia
-drug overdose
-edema/ascites
pulmonary edema |
|
|
Term
| main ADEs with electrolytes due to loop diuretics-3 |
|
Definition
hypochlor- metabolic alkolosis
-hypomag, hypokalmeia |
|
|
Term
| decrease in what ions can cause arrthymia |
|
Definition
|
|
Term
| decraease in Na can cause |
|
Definition
| hypotonia, circulatory collpase, thromoembolism |
|
|
Term
| Main ADEs of loops not coorelated with eelctrolytes -4 |
|
Definition
ototoxicity
hyperuriceima
hyperglycemia
increase LDL. decrease HDL |
|
|
Term
| which loop diuretic has the most potency |
|
Definition
|
|
Term
|
Definition
|
|
Term
| MAO of thiazides- what does it inhibit |
|
Definition
|
|
Term
wat do thiazides decrease reabsorption of directly?
indirectly? |
|
Definition
|
|
Term
| chronic use of thiazides can increase concentraitons of? -2 |
|
Definition
|
|
Term
|
Definition
HTN
Ca nephroliathis
edema
nephrogenic diabetes |
|
|
Term
GFR is lower than 35 ml/min-effect on thiazide?
exceptions? |
|
Definition
diuretic (nothing on BP lowering)
indapimide, metalazone |
|
|
Term
| main ADes of thiazides resulting from electrolytes-4 |
|
Definition
hypotension
hypoCl, HypoKHypo Na,
hyper Ca
hypo Mg |
|
|
Term
| main ADEs of thiazides not resulting from electrolytes-3 |
|
Definition
reduced glucose tolerance
sex dysfunction
increase LDL, total cholesterol, TGs |
|
|
Term
| which K sparing diuretics work on the renal epithelial Na channel |
|
Definition
|
|
Term
| where do all K-sparing diuretics work? |
|
Definition
| late distal tubule and collecting duct |
|
|
Term
| triamterene can cause what speicfic ADEs? |
|
Definition
| reduce glucose tolerance, photosensitive |
|
|
Term
| the K spairing diuretics that work on Na channel have what ADES? -4 |
|
Definition
hyperklaemia
heachade, nasuea, diarrhea |
|
|
Term
| What type of diuretic are the aldosterone antagonists? |
|
Definition
|
|
Term
| what kind of sterroid is aldosterone? |
|
Definition
|
|
Term
| where is aldosterone synthesized? |
|
Definition
|
|
Term
| where are the aldosterone recptors? |
|
Definition
|
|
Term
aldosterone increase secretion of _
but decrease secretion of? |
|
Definition
|
|
Term
| aldosterone antagonists cna be used alone for what disease? |
|
Definition
|
|
Term
| what med can be used in hyperaldosteronism? |
|
Definition
|
|
Term
|
Definition
gynecstomia, sex impotent, decrease libido;
alter clearence of digtitalis glycosides |
|
|
