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electro-chemical network of the body system body's defense system |
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Enemies to the body that cause diseases. They are needed to activate the immune system. |
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Immune system is ______ dependent |
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What are the 2 forms of immunity? |
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ability to recognize what does not belong; network of cells and lymphoid organs that owrk togeether to defen against foreign invadors aka pathogens |
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Name the different kinds of pathogens |
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bacteria, viruses, parasties, fungi |
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If the immune system misfires the result is ______ |
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autoimmune disease such as allergy, arthritis, cancer, AIDS |
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T/F All antigens are pathogens |
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If you do not a have a ____ marker you are an invador |
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Every single antigen has a |
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anything that triggers the immune response |
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Name examples of antigens |
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allergens, viruses, parts of viruses, bacteria, protozoa, tissue or cells (except from identical twins), nutrients |
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unharmful antigen that triggers immune response such as cat hair, pollen |
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Body will reject nourishing proteins in food unless they are broken down by |
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T/F Not all foods are nutrients |
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when the body mistakes itself for nonself (arthritis) |
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produce lymphocites that protect you. Dependent upon level of development |
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Name 2 major lymphoid organs and functions |
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bone marrow-cytogenesis; source of rbs and wbs
Thymus- organ behind breast bone; where lymphocytes become T cells |
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Under normal conditions, whole body is covered immunologically with |
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What are blood's 4 components and what are their componenets |
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Plasma- proteins, glucose, cell waste, extracellular fluid
WBC-granulocytes and agranulocytes
Platelets-clotting
RBCs- contain hemoglobin which carry O2 |
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Cluster Designations (CD) |
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international nomenclature of cell surace proteins that antibodies recognize. |
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Cell surface proteins may look the _____ but perfom _____ functions |
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What occurs with immune response with first exposure to toxin/antigen? |
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no immediate antibodies detectable time lag --> Abs detectable in serum after several days--> level peaks --> declines--> disappears. --> confers relatively small immunity. |
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What occurs with immune response with 2nd exposure to toxin/antigen? |
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shorter time lag --> rapid ---> rise serum Abs--> greater peak --> declines slowly --> Abs detected for months after injection. |
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What occurs with immune response with 3rd exposure to toxin/antigen? |
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even shorter lag time --> faster and higher peak --> more pronounced Ab response |
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stimulation of resistance to disease through the use of repeated injections of antigens --> basis of current vaccination techniques. |
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Cell mediated;skin from a dog --> grafted --> unrelated dog -> survives --> rejected slowly. This slow rejection is called |
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Cell mediated: If 2nd skin draft from same donor -> same recipient -->rapid rejection within days. This rapid rejection process of the 2nd graft is called |
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Name all the myeloid cells |
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neutrophil, eosinophil, basophil, monocytes |
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myeloid stem cell; circulate in bloodstreams, migrate to tissue and differentiate into macrophages |
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phagocytic; secrete hydrolytic enzymes, soluble factors, and cytotoxic proteins |
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myeloid; potent antigen presenting cell (APC), no activation needed |
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myeloid, phagocytic; first response to inflammation |
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myeloid; phagocytic; anti-parasitic |
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myeloid; nonphagocytic; allergic responses |
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3 sentinel cells of innate that contain TLR |
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macrophages, mast cells, dendritic cells |
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What are the granulocytes? |
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BEND basophils, eosinophils, neutrophils, dendritic cells |
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What are the agranulocytes? |
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lymphocytes, NK cells, monocytes, mast cells |
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List all phagocytic cells |
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monocytes, eosinphils, neutrophils |
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macrophages in connective tissue |
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macrophages in bone marrow |
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The phagocytic cells of mammals belong to 2 complementary systems: |
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The myeloid system ( rapid action but incapable of sustained effort) predominant cell: macrophages are able to replicate themselves
The mononuclear-phagocytic system (cells that act more slowly but capable of sustained and repeated phagocytosis) |
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Definition
the ability to induce immune response (humoral and/or cell mediating immune response) |
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ability to combine specifically with antibodies and/or cell surface receptors |
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is an antigen but an antigen is not an immunogen |
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small molecules that posses the properties of antigenicity but are not capable of inducing immune response because they lack immunogenicity |
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the ability to induce immune response (humoral and/or cell mediating immune response) |
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ability to combine specifically with antibodies and/or cell surface receptors |
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is an antigen but an antigen is not an immunogen |
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small molecules that posses the properties of antigenicity but are not capable of inducing immune response because they lack immunogenicity |
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Epitopes or antigenic determinants |
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macromolecule/antigesn have areas on their surfaces gainst which immune response tends to be directed an where antibodies bind. |
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The selection of epitopes by immune system is controlled by genes called |
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antibody serum protein precipitate when protein in serum is added with saturated (NH4)2S04 solution |
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antibody that remains in solution when protein in serum is added with saturated (NH4)2S04 solution |
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The primary structure, the amino acid sequence, accounts for the variable and constant regions of the heavy and light chains. (T/F?) |
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