Term
| What are the common sources of ethylene glycol poisoniing? |
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Definition
-automotive antifreeze
-heat exchenage equipment
-industrial solvents
-windshield cleaning solutions
-color film processing solutions |
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Term
| What is the seasonality of ethylene glycol poisoning? |
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Definition
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Term
| Describe the species susceptibility of ethylene glycol poisoning? |
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Definition
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Term
| What is the prognosis of ethylene glycol poisoning? Case fataliyt rate? |
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Definition
-grave prgnosis
-Dog: 44-70%
-Cat: 78-96% |
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Term
| How long does it take for ethylene glycol to be absorbed? |
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Definition
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Term
| How long does it take ethylene glycol to be metabolized? |
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Definition
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Term
| Is ethylene glycol the direct issue in a poisoning case? |
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Definition
| -no, it is the metabolytes that are the problem |
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Term
| What is the enzyme that sets of the cascade of catastrophe with ethylene glycol poisoning? |
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Definition
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Term
| Why does it matter what the major enzyme is with ethylene glycol poisoning? |
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Definition
-it is the basis of our treatment
-give them alcohol to competitively inhibit the enzyme |
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Term
| What are the stages of ethylene glycol poisoning? |
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Definition
-Stage I: 30 min-12 hr poist ingestion
-Stage II: 12-24 hours post ingestion
-Stage III: 24-72 hrs post ingestion |
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Term
| What are the clinical signs of stage I ethylene glycol poisoning? |
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Definition
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Term
| What are the clinical signs of stage II ethylene glycol poisoning? |
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Definition
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Term
| What are the clinical signs of stage III ethylene glycol poisoning? |
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Definition
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Term
| How do we clinicall diagnose ethylene glycol poisoning? |
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Definition
-history
-intuition
-exam: Wood's lamp
-commercially available EGT kit
-clinical pathology data |
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Term
|
Definition
-blood, plasma, serum
-false positive test: slug bait, activated charcoal
-for ethylene glycol poisoning |
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Term
| What are EGT test strips? |
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Definition
-plasma only
-false positive test if ethanol was already used as treatment |
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Term
| What does it mean if the EGT test is positive? What if it is negative? |
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Definition
-Positive = got into it within the last 24 hrs
-Negative = got into it over 24 hrs ago |
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Term
| What is the clin path data that diagnoses ethylene glycol poisoning? |
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Definition
-inc anion gap
-crystalluria: calcium oxalate monohydrates |
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Term
| What do calcium oxalate monohydrate crystals look like? |
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Definition
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Term
| When do we see picket fence crystals? |
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Definition
| -1-3 days after ingestion |
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Term
| How do we treat ethylene glycol poisoning?0 |
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Definition
-control absorption
-control metabolism
-control acidosis
-potential dialysis for concurrent renal failure |
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Term
| If ingested under 4 hours, how do we treat ethylene glycol poisoning? |
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Definition
-induce vomiting
-activated charcoal |
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Term
| How do we treat if we treat ethylene glycol poisoning at 16-24 hours? |
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Definition
-ethanol with sterile saline
-Everclear: 1 in 5
-fomepizole |
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Term
| What are the pros and cons of ethanol as a treatment for ethylene glycol poisoning? |
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Definition
-Pro: cheap
-Con: your patient is intoxicated, admin intervals |
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Term
| What are the pros and cons of treating ethanylene glycol poisoning with antizol? |
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Definition
-Pro: avoid alcohol CNS depression
-Con: expensiv |
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Term
| HOw do we control renal failure with ethylene glycol pisoning? |
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Definition
-treat acidosis
-dialysis
-fluids: but be careful b/c cannot urinate |
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