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A substructire of the limbic system and is involved in the control of emotional activities, including the mediation of defenseive-aggressive behaviros and attachment of emotions to memories. |
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Is most often caused by brain trauma that affects the right parietal lobe and involves a lack of awarenesss of one's symptoms on the left side of the body |
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Anticholinergic Side Effects |
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Are caused by several drugs including the antipsychotics and tricyclic antidepressants. They include dry mouth, blurred vision, tachycardia (rapid heart rate), urinary retention, constipation, memory impairment, and confusion |
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Refers to impairments in the production and/or comprehension of language.
Broca's aphasia is produced by damage to Broca's area. It involves difficulty in producing written or spoken language with little or no trouble in understanding language.
Wernicke's aphasia is caused by damage to the Wernicke's area. It is characterized by an inability to comprehend written or spoken language along with the production of rapid, seemingly effortless speach that is lacking in content and may include anomia and paraphasia.
Conduction Aphasia is produced by damage to the arcuate fasciculus. It does not significantly affect language comprehension but does result in anomia and an inability to repeat words or simple phrases. |
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The inability to perform voluntary movements, especially those involving a sequence of movements. It is often the result of parietal lobe damage. |
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Ataxia refers to a lack of coordination while performing voluntary movements. It often involves clumsiness and loss of balance. Ataxia is usually due to damage to the cerebellum (e.g., as a result of alcohol consumption). |
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The atypical (newer) antipsychotic drugs (e.g., clozapine) affect receptors for several neurotransmitters including dopamine, serotonin, and glutamate. These drugs are effective for both positive and negaitve symptoms of Schizophrenia and are less likely to produce tardive dyskinesia than the traditional antipsychotics. |
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Autonomic Nervous System (ANS) |
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A vision of the peripheral nervous system and is involved in the control of visceral functions (e.g., heart rate, blood pressure, respiration, digestion, and sweating). It consists of the sympathetic and parasympathetic branches.
They sympathetic branch is involved in the mediation of the flight or fight (emergency) reactions. Activation of this branch produces increased heart rate, pupil dilation, increased blood sugar, and inhibition of the digestive processes.
The parasympathetic branch is involved in the conservation of energy and relaxation; activation is associated with slowing of heart rate, lowered blood pressure, contraction of pupils, reduction of sweat glad output, and increased activity of the digestive system. |
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Are subcortical structures (caudate nucleus, putamen, globus pallidus, and substantia nigra) that are involved in planning, organizing, and coordinating voluntart movements. Damage to the basal ganglia is associated with Huntingtons's Disease and Parkinson's Disease. |
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Beta-blockers (propranolol) block or diminish the cardiovascular excitatory response to teh hormones epinephrine and morepinephrine. They are used to treat cardivascular disorders, glaucoma, and mograine headache and are also used for reducing the physical sympoms of anxiety. |
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The cerebellum is a large structure on the dorsal aspect of the hindbrain. It is involved in the extrapryamidal control of motor activities (e.g., coordination, balance, posture); damage can result in ataxia |
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A cerebral stroke refers to brain damage that occurs when a blood clot or other obstruction or hemorrhage disrups the flow of blood to the brain. Common symptoms include contralateral hemiplegia, hemianesthesia involving the face, arm, and leg, and contralateral visual field loss. |
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The ventricles are the four cavities of the brain that contain cerebrospinal fluid. Blockage of the ventricles and a resulting build-up of fluid can cause hydrocephalus. |
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A closed-head injury involves cerebral trauma caused by blow to the head. It is often followed by a period of loss of consciousness (coma) followed by posttraumatic (anterograde) amnesia. It may also involve retrograde amnesia and other symptoms, depending on the nature and severity of the injury. |
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Contralateral Representation |
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For most sensory and motor functions, the cortex exhibits contralateral representation, which leans that the left hemisphere controls the functions of the right side of the body, and vice versa. The right and left hemispheres are connected by several bundles of fibers, the largest of which is the corpus callosum. If the corpus callosum is severed, the two hemispheres operate essentially as separate, independent brains. |
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According to this hypothesis, Schizophrenia is due to overactivity or oversensitivity at dopamine receptors. |
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Emotion (areas of the brain) |
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Definition
Areas of the brain that have been implicated in the regulartion of emotion include the:
- amygdala (which plays a role in the perception and expression of anger, fear, sadness, happiness, and other emotions and attaches emotion to memories)
- hypothalamus (which is involved in the translation of emotions into physical responses)
- cerebral cortex. The left hemisphere governs happiness and other positive emotions, while the right hemisphere mediates sadness, fear, and other negative emotions
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Contains the primary motor, premotor, and prefrontal areas. It is involved in initiative, planning ability, abstract thinking, and other executive functions; personality and mood; and motor functions. Damage to the prefrontal cortex produces personality changes and detects in higher-level cognitive abilities. |
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Acording to this theory, there are mechanisms in the spinal cord that mediate (block) the perception of pain |
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General Adaptation Syndrom |
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According to Selye, the human response to stress is mediated by adrenal-putuitary secretions (e.g., cortisol) and involves three stages: alarm reaction, resistance, and exhaustion. The model predicts that prolonged stress can result in illness or death. |
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Hemispheric Specialization |
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Definition
Although the left and right hemispheres are both involved to some degree in most functions, they tend to specalize.
The left (dominant) hemisphere dominates in verbal activities (spontaneous speaking and writing, word recognition, memory for words and numbers); logical thought; and positive emotional states
The right (non-dominant) hemisphere dominates in visual-spacial activities such as facial recognition, spatial interpretation and memory for shapes and in negative emotions.
The specailization of the two hemispheres was initially studied in slit-brain patients, whose corpus callosums had been severed to control severe epilepsy. |
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The hippocampus is a limbic system structure that is important for spatial and explicit memory and the consolidation of declaritive memories. |
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An inherited degenerative disease that is transmitted by a single dominant gene and involves emotional, cognitive, and motor symptoms. Early symtoms are often depression, apathy, anxiety, antisocial tendencies, forgetfulness, fidgeting, and clumsiness. Later, athetosis and chorea and more severe cognitive symptoms develop. It is believed to be due to loss of GABA-secreting neurons and glutamate exitotoxicity in the basal ganglig, especially in the caudate nucleus, putamen, and globus pallidus. |
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There are two types of hypertension. Primary (essential) hypertension is diagnosed when high blood pressure is not due to a known psychological cause, while secondary hypertension is diagnosed when elevated blookd pressure is related to a knwon disease. Primary hypertension accounts for about 85 to 90% of all caes of high blood pressure; untreated, it can lead to cardivascular disease, and it is a major cause of heart failure, kidney failure, and stroke. |
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Hyperthyroidism and Hypothyroidism |
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Definition
Hyper - is caused by hypersecretion of thyroxine by the thyroid gland and is characterized by a speed-up metabolism, elevated body temperature, accelerated heart rate, increased appetite with weight loss, exophthalmos, nervousness, and insomnia
Hpyo - is caused by hyposecretion of thyroxine and involves a slowed metabolism, slowed heart rate, lethargy, lowered body temperature, impaired concentration and memory, and depression. |
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Consists of a cluster of nuclei, which control the autonomic nervous system and endocrin glands, mediates basic drives, and regulate emotional expression. The suprachiasmatic nucleus (SCN), which is located in teh hypothalamus, is involved in regulation of the body's circadian rhythms. |
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Learning and Memory (areas of the brain) |
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Definition
Areas of the brain involved in learning and memory include the following:
- Temporal lobes - essential for the encoding, storage, and retrieval of long-term declarative memories
- hippocampus - responsible for the consolidation of long-term declarative memories (transferring information from short-term to long-term memory).
- amygdala - plays a key role in fear conditioning, learning about rewards and punishments, and adding emotional significance to memories
- prefrontal cortex - implicated in short-term memory, episodic memory, and prospective memory
- thalamus - involved in processing informationand transferring it to the neocortex
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Learning and Memory (Neural Mechanisms) |
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Definition
Specific neural mechanisms that are believed to mediate long-term memory include the following: (1) long-term potentiation (a physiological process involving the modification of nerve synapses, especially at glutamate receptors in the hippocampus); and (2) protein synthesis (inhibition of the synthesis of protein or RNA at the time of learning prevents the formation of long-term memories). |
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Antidepressants that work by inhibiting the enzyme monoamine oxidase, which is involved in deactivating dopamine, norepinephine, and serotonin. The most dangerous side effect is hypertensive crisis, which can occur when an MAOI is taken in conjunction with barbiturates, amphetamines, antihistamines, or certain other drugs, or with chicken liver, avocados, bananas, fava beans). |
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Methylphenidate (Ritalin) |
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Definition
Methylphenidate is a psychostimulant drug used to treat ADHD. Its side effects include dysphoria, decreased appetite, insomnia, and growth suppression. |
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A recurrent vascular headache characterized by severe throbbing pain, usually on one side of the head. Triggers include certain foods, alcohol, bright lights, and relaxation following physical or psychological stress. A migraine may be preceded by an aura (classic migraine) or gastrointestinal or other symptoms (common migraine). |
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Mood stabalizing drugs are used to alleviate mania and mood swings in Bipolar Disorder and include lithium and anti-convulsants (e.g. carbamazepine) |
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The drugs classified as narcotic-anagesics (opioids) have both sedative and analgesic properties. Medically, the narcotic-analgesics are used for the same reasons they were used centuries ago - i.e., as analgesics, treatments for diarrhea, and psychological and physical dependence. |
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Make it possible to study both the structure and function of the living brain. Computed tomography (CT) and magnetic resonance imaging (MRI) are structural techniques. Position-emission tomography (PET), single proton emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI) provide information on the functional activities of the brain. |
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Neuroleptic Malignant Syndrome (NMS) |
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Definition
A rare, but potentially fatal side effect of the antipsychotic drugs. It involves a rapid onset of motor, mental, and autonomic symptoms including muscle rigidity, tachycardia, hyperthermia, and altered consciousness. To avoid potentially fatal outcome, the drug must be stopped as soon as symptoms of NMS develop. |
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Chemical substances that are released from axon terminals, diffuse across synapses, and excite or inhibits receptor sites on postsynaptic nerve cells. |
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Neurotransmitters - Acetycholine |
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Definition
Mediates neuromuscular transmission, parasympathetic arousal, and memory (e.g., memory loss in Alzheimer's dementia). |
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Neurotransmitters - Norepinephrine |
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Mediates the activities of the sympathetic nervous system and plays a role in the regulation of eating, sleep, and positive reinforcement. A deficiency is associated with some forms of depression |
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Neurotransmitters - Dopamine |
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Definition
Involved in inhibatory motor regulation and motivational/emotional functions. Insufficient dopamine in the basal ganglia is believed to underlie Parkinson's disease. Excessive activity at dopamine receptors has been linked to Schizophrenia and Tourette's syndrome. |
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Neurotransmitters - Serotonin |
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Definition
Ordinarily inhibits behavior and is involved in the regulation of mood, hunger, arousal, sleep, temperature, and pain and in the Affective Disorders, Schzophrenia, and OCD |
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Most common inhibitory neurotransmitter and is believed to be involved in anxiety, sleep, and seizures. Low levels of GABA in the motor region are associated with Huntington's disease. |
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Contains the primary sensory cortex for vision. Damage to this can result in visual object agnosia, color agnosia, word blindness, and/or scotomas (blind spots). |
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Contains the somatosensory cortex. Damange can cause apraxia, inability to recognize objects by touch, problems related to left-right orientation, contralateral neglect, and/or Gerstmann Syndrome. |
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A progressive gegenerative disease characterized by tremor, muscular rigidity, akathisia, akinesia, and speech difficulties; it may eventually lead to dimensia. Symptoms are temporarily relieved by L-dopa, a dompamine agonist. Parkinson's disease is believed to be due to degenerationof dopamine-containing cells, especially in the substantia nigra. |
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Postconcussional Disorder |
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Definition
In DSM-IV-TR this is included in the section of the Appendix entitled "Criteria sets and axes provided for further study". It requires (a) a history of head trauma that caused significant cerebral concussion as evidenced by a loss of consciousness, post-traumatic amnesia, and/or post-traumatic seizures; (b) distrubances in attention or memory; and (3) three or more symptoms that have lasted for at least three months (e.g., fatigure, headache, irritability, or anger without provocation) |
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The inability to recognize familiar faces including one's own face in the mirror. |
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Attempt to predict the relationship between perception and sensation. Fechner's law states that physical stimulus changes are logarithmically related to their psychological sensations. Steven's power law proposes that the magnitude of a sensation is equal to the physical magnitude of the stimulus producing the sensation raised to a certain power (exponent) which varies, depending on the specific sensation being measured. Weber's law states that the just noticeable difference in teh stimulus intensity is a constant proportion of the intial stimulus intensity. |
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Reticular Activating System (RAS) |
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A network of nerve fibers involved in wakefulness, arousal, and consciousness. |
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Secondary Sex Characteristics |
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Definition
At puberty, an increase in gonadal hormones influences the emergence of secondary sex characteristics and the development of the reproductive system. Although the mechanisms that trigger the development of the secondary sex characteristics are not well understood, it occurs when the hypothalamus secretes chemicals that stimulate the anterior pitutary gland, which then releases the gonadrotropic hormones that stimulate testosterone and sperm production by the testes or ovulation and hypothalamic-pituitary-gonadal axis. |
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The sedative-hypnotics incldue the barbiturates, anxiolytics, and alcohol. These drugs are generalized CNS depressants, and their effects, for the most part are dose dependent: At low doses, these drugs reduce arousal and motor activity; at moderate doses, they induce sedation and sleep; and at high doses, they can produce anesthesia, coma, and death. The benzodiazepines are a type of anxiolythic. Their side effects include drowsiness, ataxia, slurred speech, and other signs of CNS depression; abrupt cessation can cause rebound hpyerexcitability. |
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Definition
There are two main types of seizures:
1) Generalized seizures are bilaterally symmetrical and do not have good focal onset. Included in this category are tonic-clonic and absence seizures. Tonic-clonic (grand mal) seizures include a tonic stage in which teh muscles contract and the vody stiffens; a clonic stage that involves rhythmic shaking of the limbs; and postictal (postseizure) depression or confusion with amnesia for teh ictal event. Absence (petit mal) seizures are brief attacks involving a loss of consciousness without prominent motor symptoms.
2) Partial seizures begin in one side of the brain and affect one side of the body, at lease initially. They sometimes spread and become generalized seizures. |
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Definition
The pituitary gland and gonads (ovaries and testes) are the primary source of the sex hormones: The pituitary gland produces the gonadotropic hormones; the ovaries secrete estrogen and progesterone, and the testes secrete two types of androgens, testosterone and androstenedione. |
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Refers to sex-related differences in physical appearance; and the research has confirmed that the human brain is sexually dimorphic. Studies using structural brain imaging techniques, for instance, have found sex-related differences in the size of specific regions of the brain including the corpus callosum, hippocampus, and SCN. |
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Definition
Sleep is divided into 5 stages on the basis of EEG (electroencephalogram) patterns. Stage:
1. the sleepers EEG record is similar to that of an awake, relaxed individual and is dominated by alpha waves
2. EEG record consists primarily of theta waves that are interrupted by bursts of sleep spindles and k complexes
3. Large, slow delta waves appear
4. the "deep sleep" stage, delta waves dominate the EEG record
5. Characterized by the presence of rapid eye movement and, consequently, is known as REM (dream) sleep.
Sleep patterns vary with age. For example, total sleep time, stage 4 sleep, and REM sleep all decrease from childhood to adulthood. |
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Somatic Nervous System (SNS) |
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Consists of sensory nerves that carry information from the body's sense receptors to the CNS and motor nerves that carry information from the CNS to the skeletal muscles. The SNS governs activities that are ordinarily considered voluntary. |
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The spinal cord carries information between the brain and the peripheral nervous system, coordinates activities to the left and right sides of the body, and controls simple reflexes that do not involve the brain. In consists of 31 segments, which are divided into 5 groups. From the top of the spinal cord to the bottom, these are: cervical, thoracic, lumbar, sacral, and coccygeal. Damage at the cervical level ordinarily resutls in quadriplegia (loss of sensory and voluntary motor functioning in the arms and legs), while damage at the thoracic level causes paraplegia (loss of functioning in the legs). |
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SSRI's (Selective Serotonin Reuptake Inhibitors) |
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Definition
The SSRI's (e.g., fluoxetine) are antidepressant drugs that exert their effects by blocking the reuptake of serotonin at nerve synapses. Side effects include gastrointestinal disturbances, sexual dysfunction, insomnia, anxiety, headache, and anorexia. |
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"Joining senses" is a rare condition in which the stimulation of one sensory modality triggers a sensation in another sensory modeality. For example, a herson with synesthesia might hear a color or taste a shape. |
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Tardive dyskinesia is a potentially irreversible extrapyramidal side effect associated with long-term use of traditional antipsychotic drugs. Symptoms include rhythmical, stereotyped movements of the muscles of the face, limbs, and trunk (similar to Huntington's chorea). In some cases, symptoms are alleviated by GABA agonist or by cessation of the drug. |
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Definition
Contains the primary auditory cortex. Damage can result in auditory agnosia, Wernicke's (receptive) aphasia, cortical deafness, and/or impairments in long term memory. |
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Is a "relay station" for all of the sense except olfaction. It is also involved in language and memory. |
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There are two theories of color vision.
According to the trichromatic theory, there are three types of color receptors that are each receptive to a primary color (red, blue, or green). All other colors are produced by variations in the activity of these three receptors.
The opponent-process theory also postulates three distinct receptors: red-green, yellow-blue, and white-black. According to this theory, some cells are excited by red and inhibited by green, and so on; and the overall pattern of stimulation of these cells produces the various colors we perceive. |
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The various theories of emotion differ in terms of their emphasis on the role of peripheral and central factors. The James-Lange theory stresses the importance of peripheral factors and proposes that emotions represent perceptions of bodily reactions (especially ANS reactions) to sensory stimuli. Cannon-Bard theory places greater emphasis on the brain mechanisms that mediate emotion. It proposes that emotional and bodily reactions to stimuli occur simultaneously as a result of thalamic stimulation of the cortex and the peripheral nervous system. |
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Traditional Antipsychotics |
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Definition
The traditional use of antipsychotic drugs (e.g. phenothiazines) are used for the management of Schizophrenia and other psychoses. They are most effective for positive symptoms (delusions, hallucinations, agitation, thought disorders). Side effects include anticholinergic and extrapyramidal effects. |
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Definition
The tricyclic antidepressants (e.g., imipramine, chlomipramine) are believed to work by blocking the reuptake of norepinephrine, dopamine, and/or serotonin. They are most effective for alleviating somatic, vegetative symptoms. Side effects include anticolinergic effects, confusion, drowsiness, weight gain, and cardiovascular symptoms. |
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Definition
People exhibiting this behavior pattern are highly competetive and achievement-oriented, have a sense of time urgency, and tend to be hostile, easily irritated, and impatient. A number of studies have confirmed that, of the Type A characteristics, cynical or antagonistic hostility is most strongly associated with health problems, especially coronary heart disease in males. |
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"Visual not knowing" -- is an inability to recongize familiar objects by sight. |
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