Term
| What holds substrate at active site? |
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Definition
chemical bonds
physical interactions |
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Term
| Describe lock and key model for enzymes |
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Definition
enzyme is rigid 3D body
Enzyme surface contains the active site |
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Term
| Describe the induced fit model. |
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Definition
| Actie site becomes modified to accommodate the substrate |
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Term
| Which amino acids participate in teh active sites of more than 65% of enzymes |
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Definition
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Term
| What occurs at the active site? |
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Definition
| selection of a stereoisomer |
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Term
| What is at the active site of Trypsin? |
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Definition
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Term
| What is the well for that is created by Chymotrypsin? |
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Definition
| Phenylalanine, Tryptophan, and Tyrosine |
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Term
| What factors affect teh rate of an enzyme-catalyzed reaction? |
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Definition
1. enzyme concentration
2. substrate concentration
3. temperature
4. pH |
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Term
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Definition
| any process that initiates or increases the activity of an enzyme |
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Term
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Definition
| any process that makes an active enzyme less active or inactive |
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Term
| What is a competitive inhibitor: |
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Definition
| any substance that binds to the active site of an enzyme thereby preventing binding of substrate |
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Term
| What is a noncompetitive inhibitor |
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Definition
| Any substanc hat binds to a portion of the enzyme othr than the active site and thereby inhibits the activity of the enzyme |
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Term
| Which has more of a detrimental effect on the enzyme- competitive inhibitor or noncompetitive inhibitor |
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Definition
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Term
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Definition
| An enzyme regulatin process where the product of a series of enzyme-catalyzed reactions inhibits an earlier reaction in the sequence. The inhibition may be cometitive or noncompetitive |
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Term
| Name an inactive form of an enzyme |
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Definition
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Term
| How does an inactive form of an enzyme become activated? |
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Definition
| Part of a polypeptide chain must be removed by hydrolysis to activate the enzyme |
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Term
| What is an example of a proteolytic enzyme |
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Definition
| Trypsin (proteolytic enzyme) synthesized and stored as trypsinogen |
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Term
| How does the molecule achieve its active form? |
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Definition
| Changing the primary structure changes the tertiary structure allowing the molecule to achieve its active form |
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Term
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Definition
| Enzyme regulation based on an event occurring at a place other than the active site but that creates a change in the active site |
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Term
| Do Allosteric enzymes have multiple polypeptde chains? |
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Definition
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Term
| What is negative and positive modulation of an Allosteric enzyme |
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Definition
Negative -inhibition of an allosteric enzyme
Postivie-stimulation of an allosteric enzyme |
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Term
| What is a regulator in regard to an Allosteric enzyme? |
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Definition
| A substance that binds to an allosteric enzyme |
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Term
| How does protein modification work with regard to enzyme regulation? |
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Definition
| the process of affecting enzyme actibity by covalently modifying it....phosphorylation and dephosphorylation |
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Term
| What is an enzyme that occurs in multiple forms, each catalyzes the same reaction? |
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Definition
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Term
| What is an example of an isoenzyme? |
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Definition
| Lactate dehydrogenase catalyzes the oxidation of lactate to pyruvate |
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Term
| What medical diagnosis is made by Acid phosphatase? |
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Definition
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Term
| What diagnosis is made by creatine phosphokinase ck? |
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Definition
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Term
| What diagnosis is made by amylase? |
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Definition
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