Term
enterobacteriaceae
name two kinds |
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Definition
salmonella spp
shigella spp |
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Term
salminella spp.
five major pathogens? |
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Definition
s. thyphimurium
s. choleraesuis
s. enteritidis
s. typhi
s. paratyphi |
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Term
| characteristic of salmonella |
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Definition
gram negative
motile (flagellated) bacillus
non-lactose fermenter (on agar plate, shows up black) |
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Term
on an envelope of salmonella, what are major antigens?
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Definition
LPS: >2400 O serotypes
>119 Hantigens for flagellum |
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Term
| among five salmonella species, which patogen causes gastroenteritis aka, food poisoning? |
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Definition
salmonella enteritidis
invasive bacterium |
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Term
| site of action of s. enteritidis? |
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Definition
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Term
| duration of gastrointeritidis? |
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Definition
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Term
salmonella elicit _____ of the ____ cytoskeleton of the host cell.
___ is observed b4 invasion by salmonella into the host cell |
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Definition
rearrangement
actin
ruffling |
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Term
| risk group for s. enteritidis? |
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Definition
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Term
| among the five salmonella species, which causes typhoid fever? |
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Definition
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Term
| risk group for typhoid fever? |
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Definition
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Term
| for typhoid fever, after dissemination from intestine via macrophages to the lymphatics, bloodstream, liver, kidneys, gall bladder, it causes |
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Definition
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Term
| one of the serious effect of typhoid fever is |
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Definition
hemorrhagic ulceration
spilling gut into abdomen |
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Term
| entery of typhi is where? |
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Definition
| gut tpithelium then becomes systemtic |
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Term
| virulence proteins expressed by salmonella? |
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Definition
pathogenicity island; virulence genes are clustered
SPI-1 |
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Term
how do you know that SPI-1 gene is virulence factor?
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Definition
| with mutaion in SPI-1 gene, salmonella can't do its job |
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Term
| what does SPI-1 encode for? |
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Definition
| Type III secretion system |
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Term
| what is Type III secretion system? |
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Definition
this introduces protein into the cytoplasm of the infected cell
Effector proteins manipulate cell function |
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Term
| type III secretion system injhects ____ into the cell |
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Definition
SIP
salmonella invasion protein
to epithelial cells |
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Term
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Definition
SSEE
almonella secretion effector protein
in phagocytes |
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Term
| what is a causative agent for bacillary dysentery ? |
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Definition
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Term
| four species of shigella? |
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Definition
shigella boydii
shigella flexneri
shigella sonnei
shigella dysenteriae |
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Term
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Definition
obligate human pathogen so
only human |
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Term
| characteristic of shigella |
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Definition
gram negative
non-motile
not ferment lactose |
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Term
| on hektoen enteric agar, shigella spp presents |
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Definition
| green, raised, moist colonies |
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Term
| envelope of a shigella spp, what are some major antigens used for serotyping? |
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Definition
~45 O anigen
LPS much less diverse than salmonella
NO flagellar antigen |
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Term
| site of onset of shigella? |
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Definition
submucosal cells of the lining of the intestine
invades thru m cell
localized to the gut |
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Term
| invasive phenotype of shigella is encoded by |
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Definition
| a large virulence plasmid which encodes Ipa and type III secretion system |
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Term
| thpe III secretion system in shigella function? |
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Definition
| injects Ipa proteins into the cell |
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Term
| how does shigella mobilize? |
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Definition
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