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Endocrinology
N/A
29
Medical
Undergraduate 1
03/20/2013

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Cards

Term
Excess production of cortisol by zona fasiculata. Caused by adrenal tumours, pituitary tumours or ectopic ACTH production
Definition
Cushing's Disease
Term
Endocrine hypertension caused by excess secretion of aldosterone from zona glomerulosa
Definition
Conn's Syndrome
Term
Mineralocorticoid, produced by outer cortical layer (Zona Glomerulosa)
Definition
Aldosterone
Term
Glucocorticoid, produced by middle cortical layer (Zona Fasciculata)
Definition
Cortisol
Term
Release: Stimulated by Angiotensin, ACTH & [ion]blood
Definition
Aldosterone
Term
Release: Stimulated by ACTH (AdrenoCorticoTropic Hormone)
Definition
Cortisol
Term
Increases Na+ & th. H2O reabsorption & increases K+ excretion in DCT. Increases activity of Na+/K+ pump in DCT, reabsorbing more Na+ & excreting more K+
Definition
Aldosterone
Term
Increases blood glucose levels & inhibits immune system. Inhibits protein synthesis, promotes fat use for energy & stimulates gluconeogenesis (i.e. glucose production from glycerol/amino acids)
Definition
Cortisol
Term
Release: Stimulated by Neurones (Preganglionic Sympathetic) from Hypothalamus
Definition
Catecholamines (Adrenaline, Noradrenaline)
Term
Features of Cushings
Definition
Metabolic Syndrome - Impaired glucose tolerance, Central obesity (& thin periphs), hyperlipidaemia, hirsutism
Term
To Confirm Cushing’s
Definition
24h Urinary Cortisol – Will be high
Term
Acute Causes of Addison's
Definition
Sudden withdrawal of long term steroids
Term
Chronic Causes of Addison's
Definition
Autoimmune adrenalitis - Most common cause, but still rare
Term
Symptoms of Conn's Syndrome
Definition
Usually asymptomatic other than HTN
Term
Phaeochromocytoma
Definition
Tumour of adrenal medulla (or sympathetic ganglion) – Only 10% malignant; 10% are familial
Term
Symptoms of phaeochromocytoma
Definition
Sweating, Tachycardia & HTN
Term
Insufficient thyroid hormone produced by thyroid
Definition
Primary hypothyroidism
Term
Excess thyroid hormones produced by thyroid gland. Most common causes are Grave's Disease and Toxic Nodular Goitre
Definition
Hyperthyroidism
Term
Enlarged thyroid gland
Definition
Goitre
Term
Primary adrenal insufficiency caused by autoimmune disease or TB
Definition
Addison's
Term
Which hormone is produced in response to low calcium
Definition
Parathyroid hormone
Term
Adenoma of hyperplasia of parathyroids causing excess PTH and elevated calcium.
Definition
Primary hyperparathyroidism
Term
Low calcium resulting from and cause leading to increased PTH
Definition
Secondary hyperparathyroidism
Term
Androgen deficiency and/or impaired sperm production
Definition
Primary hypogonadism
Term
Embryological testosterone deficiency
Definition
Foetal androgen deficiency
Term
46X 0 Chromosomes, Primary amenorrhoea, lymphoedema of hands and feet, growth failure, neck webbing and cubitus valgus
Definition
Turner's Syndrome
Term
Hypergonadotropic amenorrhea in women <40year that is genenerally ideopathic
Definition
Premature ovarian failure
Term
Which layer of the adrenal cortex produces mineralocorticoids like aldosterone
Definition
Glomerulosa
Term
Which layer of the adrenal gland produces catecholamines like adrenaline
Definition
Medulla
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