Term
| Which of the eicosanoids are pro-inflamatory? |
|
Definition
|
|
Term
| Which of the eicosanoids are less inflamatory? |
|
Definition
|
|
Term
| What are the two eicosanoid families? |
|
Definition
| Prostaniods and Leukotrienes |
|
|
Term
| What are the 3 main prostanoids? |
|
Definition
| prostaglandins, prostacyclins, tromboxains |
|
|
Term
| Explain the process of naming an ecosanoid, |
|
Definition
2 Letter abbreviation = PG
one A-B-C sequence letter = PGG
subscript indicating # of double bonds = PGG2 |
|
|
Term
| What are the two main compounds Prostanoids are derived from? |
|
Definition
Eicosapentaenoic Acid =EPA (3 double bonds)
Arachidonic Acid = AA (2 double bonds) |
|
|
Term
| Explain the synthesis of prostanoids. |
|
Definition
1. derived from fatty acids that make up cell and nuclear membrane
2. phopholipase hydrolizes phospholipids
3. relased FFA are oxygenated by
a. COX
b. Lipoxygenase |
|
|
Term
|
Definition
BABIES.
acutally, Prostanoids |
|
|
Term
| What do Lipoxygenases make? |
|
Definition
|
|
Term
| What is the function of AA cascade? |
|
Definition
forms various omega 6 EFAs of various prostanoids
esp those in inflamation, immunity and the CNS |
|
|
Term
| what is the function of the EPA cascade? |
|
Definition
formation of omega 3 FFA of other prostanoids
*soften inflammatory effects of AA prostanoids |
|
|
Term
| Are prostanoids autocrine, paracrine, or both? |
|
Definition
|
|
Term
| Prostanoids only last.... |
|
Definition
|
|
Term
| what regulates prostanoids? |
|
Definition
| G-protein-coupled receptor |
|
|
Term
| what are the activies of COX2 |
|
Definition
1. vasoconstriction
2. pain
3. fever |
|
|
Term
| what is the activity of COX 1 |
|
Definition
|
|
Term
|
Definition
Smooth muscle contractino
bronchoconstriction
induces pain, heat, fever |
|
|
Term
|
Definition
|
|
Term
|
Definition
inhibits platlet aggregation
vasodilation
embryo implantation |
|
|
Term
|
Definition
stimulates platlet aggregation
vasoconstriction |
|
|
Term
|
Definition
misoprostol
sometach ulcers and induces labor (BABIES) |
|
|
Term
|
Definition
Lantanoprost
treats glaucoma and ocular hypertension |
|
|
Term
|
Definition
Alprosadil
treats erectile dysfunction and pulmonary hypertenstion |
|
|
Term
| What drugs inhibit Prostanoid formation? |
|
Definition
COX inhibitors (asprin)
COX2 inhibitors (NSAIDS) |
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