Term
| What are the s/sx of thyroid storm? (5) |
|
Definition
| 1)High temps (104-106F) 2)Tachycardia 3)Arrythmias 4)CHF 5)Extreme agitation or psychosis |
|
|
Term
| What are the tx for thyroid storm? |
|
Definition
| Anti-thyroid meds, inorganic iodine, BB |
|
|
Term
| Differentiate b/t primary and secondary hypothyroidism. |
|
Definition
| Primary - thyroid can't produce enough hormone. Secondary - pituitary doesn't stim. thyroid to prod. hormone |
|
|
Term
| The incidence of hypothyroidism becomes increasingly common with _____. |
|
Definition
|
|
Term
| Which type of hypothyroidism is most common, primary or secondary? |
|
Definition
|
|
Term
| Name 5 causes of primary hypothyroidism. |
|
Definition
| 1)Idiopathic 2)Hashimoto's 3)Late stage invasive fibrous thyroiditis 4)Iodine def. 5)Tx for Grave's dz (irradiation or thyroidectomy) |
|
|
Term
| Name 2 drugs that can cause primary hypothyroidism. |
|
Definition
|
|
Term
| Name 4 infiltrative dz that cause hypothyroidism. |
|
Definition
| 1)Sarcoidosis 2)Amyloidosis 3)Scleroderma 4)Hemochromatosis |
|
|
Term
| Name 3 causes of secondary hypothyroidism. |
|
Definition
| 1)Pituitary or hypothalmic neoplasm 2)Congenital 3)Pituitary necrosis (Sheehan's syndrome) |
|
|
Term
| What are global s/sx of hypothyroidism? |
|
Definition
| Weakness, lethargy, cold intolerance, forgetfullness, decreased sweating |
|
|
Term
| Name skin/hair changes in hypothyroidism. |
|
Definition
| Dry/coarse skin, cold skin, pallor, coarse hair |
|
|
Term
| What are facial/speech s/sx of hypothyroidism? |
|
Definition
| Eyelid/facial edema, thick tongue, slow speech |
|
|
Term
| What is a GI sx of hypothyroidism? |
|
Definition
|
|
Term
| What lab findings are expected in primary hypothyroidism? |
|
Definition
| Elevated TSH and low free thyroid hormone |
|
|
Term
| What lab findings are expected in secondary hypothyroidism? |
|
Definition
|
|
Term
| What is the tx for hypothyroidism? |
|
Definition
|
|
Term
| What conditions necessitate higher dosages of thyroid HRT? |
|
Definition
| Conditions that increase serum binding proteins (high estrogen states, OCP, post-menopausal HT) |
|
|
Term
| What conditions necessitate decreased doasges of thyroid HRT? |
|
Definition
| Conditions that decrease serum binding proteins (androgens, elderly, nephrosis, protein losing enteropathies, cirrhosis) |
|
|
Term
| what is subclinical hypothyroidism? |
|
Definition
| Mildly elevated TSH w/ normal T3/T4, reflects early failure |
|
|
Term
| Name 2 risk factors for thyroid CA. |
|
Definition
|
|
Term
| What is the MC type of thyroid CA? |
|
Definition
|
|
Term
| What gender has the worst prognosis for thyroid CA? |
|
Definition
|
|
Term
| What are red flags for thyroid CA? (5) |
|
Definition
| 1)Age <20 or >65 2)Rapid growth 3)Dysphagia, hoarseness, neck pain 4)h/o XRT to neck or head 5)Fhx thyroid CA or polyposis |
|
|
Term
| What is the prognosis of papillary thyroid CA? |
|
Definition
|
|
Term
| What is the tx for most types of thyroid CA to reduce risk of local recurrence? |
|
Definition
| Radioactive Iodine-131 therapy |
|
|
Term
| What types of thyroid CA do not respone to radioactive iodine? |
|
Definition
|
|
Term
| what is the most aggresive form of thyroid CA? Describe it. |
|
Definition
| Anaplastic thyroid CA, present in elderly w/ rapidly enlarging mass in a multinodular goiter |
|
|
Term
| Which type of thyroid CA causes flushing and diarrhea in 30% of pts? What causes these sx? |
|
Definition
| Medullary, serotonic and prostaglandins |
|
|
Term
| What is the clinical finding in thyroid CA? |
|
Definition
| Palpable, firm, non-tender nodule |
|
|
Term
| What are lab findings in thyroid CA? |
|
Definition
| Thyroid function test normal, high serum thyroglobulin |
|
|
Term
| Increased calcitonic levels in which type of thyroid CA is a good indicator of recurrence? |
|
Definition
|
|
Term
| What is the preferred test to distinguish b/t malignant and benign thyroid nodules? |
|
Definition
|
|
Term
| What are risks associated with radical neck surgery for thyroid CA? |
|
Definition
| Permanent hypothyroidism or hypoparathyroidism, or vocal cord paralysis d/t recurrent laryngeal n. damage |
|
|
Term
| What is the TOC for thyroid CA? |
|
Definition
| Thyroidectomy w/ limited removal of cervical lymph nodes |
|
|
Term
| What is the surgical TOC for medullary thyroid CA? |
|
Definition
|
|
