Term
| What does the Zona Fasciculata produce and what does it do? |
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Definition
| Glucocorticoids (Cortisol). |
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Term
| What effects do glucocorticoids have physiologically? |
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Definition
| Cortisol maintains normal level of glucose in the blood. Gluconeogenesis, in liver. Synthesis of glucose from amino acids and lipids.2. Mobilization of amino acids from extrahepatic tissues: serve as substrates for gluconeogenesis. 3. Inhibition of glucose uptake in muscle and adipose tissue. 4. Stimulation of fat breakdown in adipose tissue. 5. Glucocorticoids have potent anti-inflammatory and immunosuppresive properties. 6. Overall, glucocorticoids are essential for the response to stress. |
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Term
| Anti-inflammatory effects |
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Definition
| 1. Glucocorticoids induce the synthesis of lipocortin, an inhibitor of phospholipase A2. 2. Glucocorticoids inhibit the production of interleukin-2 and inhibit proliferation of T lymphocytes. 3. Glucocorticoids inhibit release of histamine and serotonin from mast cells and platelets. |
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Term
| Anti-inflammatory Effects of Glucocorticoids |
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Definition
| 1. Induce synthesis of lipocortin, an inhibitor of phospholipase A2. Anti-inflammatory properties by inhibiting formatino of precursor. 2. inhibit production of interleukin and inhibit proliferation of T lymphocytes. 3. Glucocorticoids inhibit release of histamine and serotonin from mast cells and platelets. |
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Term
| Immunosuppressive Mechanism |
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Definition
| Glucocorticoids suppress cell-mediated immunity. act by inhibiting genes that code for cytokines IL-1, IL-2, IL-3, IL-4, thorugh 8. Smaller cytokine production reduces T cell proliferation. Supress humoral immunity causeing B cells to express smaller amounts of IL-2 and Il-2 receptors. Diminishes both B cll clone expansion and antibody synthesis. less lymphocytes to be activated. |
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