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Endocrine System
N/A
65
Physiology
Undergraduate 2
10/28/2008

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Term
Endocrine System
Definition
this system is an older communication system that is integrated with the CNS & hormones
Term
Endocrine Glands
Definition
(see drawing)
Term
Three types of hormones
Definition
Peptides, Modified Amino Acids and Steroid Hormones
Term
Peptide
Definition
these are strings of amino acids
Term
This hormone is a modified amino acid. what is it made from?
Definition
norepinephrine is one of this type of hormone: it is made from tyrozine (peptide) + and enzyme.
Term
thyroxine
Definition
this main thyroid hormone affect thought/information processing (lower this hormone, lowers intelligence)
Term
Steroid Hormone
Definition
this hormone is made from cholesterol (i.e. testosterone). These are fat soluable (pass through membranes) and cannot be packaged into vessicles. One example is anabolic steroids.
Term
Protein Hormone receptors
Definition
these type of hormone (peptides & modified amino acids) are metabotropic (have second messenger)
Term
Protein Hormone receptors
Definition
these type of hormone (peptides & modified amino acids) are metabotropic (have second messenger)
Term
Steroid hormone receptors
Definition
these types of hormones use receptors within the nucleus of the cell: they make a profound, function-related effect compared to protein receptors
Term
Posterior Pituitary (and what it's made of)
Definition
This pituitary stores hormones and can be stimulated by the brain. It grows downward and is made of neural tissue (neurons and synapses)
Term
Anterior Pituitary
Definition
this pituitary dev't from the roof of the mouth, and grows upward. It has no neurons or synapses. Think "ANTI-brain"
Term
What controls the anterior pituitary?
Definition
the hypothalamus controls this pituitary through hormones sent from the brain, which are then released into the bloodstream, specifically the "growth hormone"
Term
FSH
Definition
Follicle stimulating hormone
Term
LH
Definition
Luteninizing Hormone
Term
FSH + LH
Definition
these two hormones that control the gonads are produced by the anterior pituitary
Term
Gonadotropic Releasing Hormone (GnRH)
Definition
this hormone is synthesized by the hypothalamus and once released into the bloodstream goes to the pituitary and synthesized FSH + LH
Term
male system of negative feedback and modulation by environmental effects:
Definition
this system involves the brain (sexuality, stress + other factors), the pituitary (where GnRH is used to make FSH + LH), the testes (where FSH + LH are used to make androgen + for spermatogenis) and the genetalia (where testosterone is made/used)
Term
negative feedback
Definition
drop below set point, induce, go above a set point, inhibit = thermostat. This is how the brain stops or starts release of GnRH
Term
testosterone activity
Definition
people who win have testosterone go up: stressful events make testosterone goes down
Term
Estrodial
Definition
this is the main estrogen in humans, main sex hormone in females.
Term
positive feedback
Definition
exceed a certain point, the system turns on. In women, a high level of estradiol leads to a surge in GnRH which = a surge in FSH + LH (so egg can be released)
Term
Female reproductive system
Definition
As the follicule develops, the uterial endometrium (uterus wall) is growing, getting ready to form the placenta. At ovulation, the egg is released, there is a surge in LH and a slight increase in FSH right after. Eventually, menses
Term
sexuality vs. sex
Definition
social construction vs. male/female
Term
Reproduction
Definition
social behavior for survival of species
Term
Sexually Dimorphic
Definition
this referes to behaviors that are diff't in males and females
Term
organizational effect
Definition
the affect of a hormone that results in a permanent change (breasts)
Term
activational effect
Definition
the effect of a hormone that is dependent on the hormone being present/ temporary effect
Term
Chromosomal pair
Definition
this number 23 is determined at fertilization
Term
Which gonads dev't....
Definition
....is controlled by chromosomal sex
Term
anti-mullerian hormone
Definition
this hormone is secreted by the testes during fetal dev't. It inhibits the mullerian ducts, the female set of tubes heading towards the gonads. It is said that this hormone has a determinizing effect
Term
Woffian duct
Definition
these male tubes which connect to gonads won't dev't unless encouraged by androgens (like testosterone). This involves a critical period.
Term
urethra
Definition
XX => urethra stays open
XY => urethra stays closed
Term
male testes secrete
Definition
anti-mullerian hormone + 2 Androgens: testosterone & dihydrotestosterone
Term
masculinization & defeminization
Definition
these are describing the actions of anti-mullerian hormone & androgens, respectively in how an XY system makes the female bits wither away.
Term
Ambiguous genetalia
Definition
less androgen = less genital masculinization
Term
XX with high androgen
Definition
ambiguous genitalia
Term
XY with low androgen
Definition
ambiguous genitalia
Term
Testicular Feminization
Definition
in order for a hormone to have an effect it must have a receptor: this effect is when, although the testes put out testosterone, the woffian ducts don 't develop...have testes, but external female genitals
Term
androgen receptor defect
Definition
peudohermaphrodite/ testicular feminization
Term
no hair under arms @ puberty, never menstruates
Definition
testicular feminization/ androgen receptor defect/ pseudohermaphrodite
Term
XXY
Definition
Klinefelter's Syndrome : male genitals, generally small
Term
XO
Definition
Turner's Syndrome: female genitals, ovaries don't dev't, puberty fails
Term
XX/XY
Definition
also known as "true hermaphrodite" with both sets of genetalia (one on each side), usually two gonadal cells that fuse
Term
XXX
Definition
Triple-X, normally female but w/extra learning disability
Term
XYY
Definition
Supernuerary Y: male dev't: tall, impulsive w/ some learning disabilites (think prison)
Term
sexual behavior is induced by...
Definition
hormone activity (adding testosterone or estradiol) induces...
Term
Sexual differences in behaviors
Definition
play, aggresive behavior, parental behavior, maze learning, taste preferences
Term
Sexually-Dimorphic Nucleus of Pre-Optic-Area (SDN of POA)
Definition
this area of the brain is affected by hormones: a female version of the SDN POA will dev't in males if they're castrated at birth
Term
humans are treated...
Definition
consistent with their biology, and therefore, it is hard to measure diff'ce in male/female brains. We're treated differently from birth
Term
XX Children with (CAH) Congential Adrenal Hyperplasia
Definition
these females have masculinization of external genetalia b/c their adrenal gland starts producing androgens (testosterone). They have reconstrcutive surgery but have a higher incidence of being "tom boys"
Term
5a reductase deficiency (DHT not made) or "huevo a los doce"
Definition
this disorder is like in MIDDLESEX: XY born with ambiguous genitalia are raised as girls, eventually identify as boys
Term
oxytocin
Definition
contributes to smooth muscle contraction in orgasm in males & females - sometimes referred to as a neurotransmitter. Also contributes to monagamous pair bonding.
Term
Prolactin (think: I am pro this 'cause I don't want to be ejaculated on)
Definition
this hormone has an anti-sexual effect, released during ejaculation + may mediate sexual refractory period
Term
dynorphin (think I'm dying with how pleased I am)
Definition
this endogenous opiod may contribute to male sexual satiety
Term
Medial Pre optic Area (MPoA)
Definition
this area has testosterone receptors, and if a little bit of testosterone is placed here, it brings back the sex drive in castrated animals. Electrical stimulation of this area induces copulation. It also receives input from the amygdala. Lastly, it has outputs to the brainstem and to motor control (thrusting)
Term
Ventral Tegmental Area
Definition
during Orgasm there is brain activity in this region
Term
Ventromedial Hypothalamus (VMH)
Definition
this part of the brain mediates effect of hormone in female sex activity: small amount of estradiol in VMH = initiate activity. Estradiol increases number of progesterone receptors
Term
XX individuals who secrete more testosterone than normal (CAH exposure)
Definition
are slightly more likely to identify as tomboys and be gay.
Term
Inject gay, straight men and straight women with estrogen
Definition
gay men have feedback halfway inbetween straight men and women
Term
Sexually Diamorphic Nucleus of the PoA
Definition
homosexual men have same size as women
Term
Pheromone
Definition
Chemicals that transmit a message from one animal to another
Term
Lee-Boot effect
Definition
esterus cycle stops when groups of female mice are housed together (a lot of booty in one place at one time = no menstruation!)
Term
Whitten Effect
Definition
the esterous cycle starts in synchrony when a group of female mice are exposed to urine of male mouse (wheee!)
Term
Bruce effect
Definition
failure of a pregnancy when a recently impregnated mouse is exposed to a normal male mouse (think how bruce's voice could give me an abortion)
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