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organ + cells glandular in nature + maintain homeostasis |
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-produced by endocrine cells -messengers to cause adjustment -travel through blood to target cells *absorbed into plasma *carriers (actually ptn) |
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hydrophilic, does not require a carrier |
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hydrophobic, requires a carrier, diffuses into plasma |
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Is water soluble in plasma? |
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water bonds to this secondary carrier/messenger |
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high concentration in blood, cut back production |
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decrease receptor by target cells |
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target cells increase receptors |
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base of brain; small area, high concentration of neurotransmitters + neuropeptides -releasing hormones control the hormones released by the ant pit -produces ACh, dopamine, norepinephrine, CRH, GHRH, etc |
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CRH (Corticotropin Releasing Hormone) |
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responds to stress by effecting hormones |
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GHRH (Growth Hormone Releasing Hormone) |
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causes release of growth hormone |
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small gland at base of skull |
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portal system of cappilaries from the hypothalamus (glandular) (releaseing hormone) -respond to chemical (hormonal) messages sent from the hypothalamus
Hormones: ACTH, TSH, Growth Hormone |
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neurons from the hypothalamus (neural) -works with kidneys to regulate free water from the urine back to the blood stream
Hormones: Antidiuretic Hormone |
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ACTH (Adrenocorticotropin Hormone) |
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carried to adrenal gland to release molecules manufactured there |
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Thyroid Stimulating Hormone, regulates basal metabolic rate (metabolism) -mitochondria of the target cells are caused to increase metabolism in order to create more ATP |
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anabolism (production of ptn that leads to growth and maturation) - build up |
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vasoconstrictor, regulates vascular volume and serum concentration (amount of glucose in blood) |
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amount of glucose in the blood |
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melatonin - antioxidant -sleep -anti-aging |
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produced in thyroid if too much Ca in blood... -bonds w/ osteoclasts to inhibit resorption of Ca from blood -stop absorbing as much through digestive tract -kidney decrease recapture of Ca from urine |
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size of pea produces PTH reverses effect of calcitonin -bonds w/ osteoclasts for more resorption -absorb more Ca through digestive tract -kidneys increase recapture of Ca from urine |
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produces thymosin -maturation of T cells (immune system) -decrease as we age |
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islets of langerhan insulin glucagon glycogenolysis glycogneogenesis |
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endocrine cells where insulin is produced |
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release triggered by levels of glucose of nervous system, get glucose out of blood and into cells |
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opposite effects of insulin, get glucose out of cells and into blood |
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causes release of stored glucose from the liver to the blood, glycogen when stored |
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(formation) from liver, increases production of glucose from other molecules (ex: fat, ptn, lactic acid) |
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-adrenal gland on top of each kidney -hormones here originate from cholesterol -aldosterone, cortisol -released when stressed to put fuel into blood -produces precursors of sex related hormones |
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homeostasis of Na and K in blood -give up K to gain Na -in kidneys |
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-goes to liver and trigger glucose produced from AA -breaks stored fat into fatty acids for fuel -anti-inflammatory properties |
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renin, aldosterone, angiotensinogen, erythropoietin |
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restore flow to kidneys, increase blood volume and blood pressure |
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ptn synthesis in liver, put into blood causes vasoconstriction and release of aldosterone (homeostasis of Na and K in blood) |
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when oxygen in the blood is low, travels to red bone marrow to effect production of more RBCs -blood doping |
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-endorphins are released in both short and long term exertion -bind to same receptor as morphine to relieve pain -endogenous morphine (opiate) -growth hormone, antidiuretic hormone (ADH) |
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Growth hormone -released because of exertion -increase in blood proportional to intensity -concentration increases immediately and levels remain high approx. 2 hrs after cessation |
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-anabolic steroid -causes cell to burn fats before glucose to spare the amount of glucose -epinephrine and norepinephrine partially responsible |
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Antidiuretic Hormone -exercise causes release -recaptures free H2O from urine -H2O is expanded in so may ways during exercise so body wants to hold onto it a. respiration (H2O vaporizes w/ breath) b. keeps blood volume regulated c. sweating |
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produces epinephrine and norepinephrine -increase HR, vasodiolation, vasoconstriction, "fight or flight" |
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exercise affects adrenal in much the same way as "fight or flight" when sympathetic is triggered -norepinephrine + epinephrine released early in exercise, benefit performance |
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Epinephrine + Norepinephrine (heart) |
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regulate increase in heartrate -act on receptions at the sinoatrial (SA) Node -increase heartrate + stroke volume -blood vessels vasodialate and vasoconstrict -increase inn cardio output |
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increase heart rate epinephrine and norepinephrine |
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increase in stroke volume norepinephrine and epinephrine |
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change affected by epinephrine and norepinephrine action on CNS may increase 2x deliver more O2 and eliminate more metabolic wastes |
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-long term exercise decreases baseline level of Epi+Norepi -less epi + norepi + their effects after long term exercise -adrenal glands ability to increase hormones can respond to demands sooner -regression of the medulla in producing hormones is rapid after cessation of exercise |
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-@exercise, >50% of VO2Max, cortisol increases in blood -trigger glugoneogenesis in liver and muscle -triggers lipolysis (breaks fat into fatty acids) -aldosterone (from adrenal) recovers Na + H2O from urine in exchange for K |
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-glucose consumption - blood + cell rises -as glucose decreases, pancrease lowers insulin -receptors for insulin are hypersensitive due to hormones -more blood supply = increase in insulin and glucose -long term training = decrease in baseline insulin, but increase in sensitivity -insulin level affected more by duration than intensity |
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-also from pancreas -increase blood concentration of glucose 1. liver glycogen released 2.gluconeogenesis 3. mobilization of fatty acids -long term training reduces amount of glucagon |
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-anabolic hormone that increases muscle mass -anaerobic activity causes immediate release -aerobic activity may reduce the amount of testosterone by 50% |
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-exercise causes an immediate release of estrogen + progesterone -prolonged training lowers estrogen + progesterone -may even lead to amenorrhea -more prominent in females w/ low body fat -critical factors: stress + low body fat -22% body fat required to maintain regular cycles |
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-exercise lowers activity in intestines -ghrelin -anaerobic activity lowers level of ghrelin -suppresses appetite |
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affect appetite -lowered by anaerobic activity -suppresses appetite |
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