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Endocrine System
Hormones
57
Health Care
Undergraduate 1
03/16/2014

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Term
endocrine system
Definition
organ + cells
glandular in nature + maintain homeostasis
Term
hormones
Definition
-produced by endocrine cells
-messengers to cause adjustment
-travel through blood to target cells
*absorbed into plasma
*carriers (actually ptn)
Term
water soluble hormones
Definition
hydrophilic, does not require a carrier
Term
lipid soluble hormones
Definition
hydrophobic, requires a carrier, diffuses into plasma
Term
steroid hormones
Definition
bond to nucleus near DNA
Term
Is water soluble in plasma?
Definition
Yes
Term
G protein
Definition
water bonds to this secondary carrier/messenger
Term
Are hormones regulated?
Definition
Yes
Term
negative feedback
Definition
high concentration in blood, cut back production
Term
down regulation
Definition
decrease receptor by target cells
Term
up regulation
Definition
target cells increase receptors
Term
hypothalamus
Definition
base of brain; small area, high concentration of neurotransmitters + neuropeptides
-releasing hormones control the hormones released by the ant pit
-produces ACh, dopamine, norepinephrine, CRH, GHRH, etc
Term
CRH (Corticotropin Releasing Hormone)
Definition
responds to stress by effecting hormones
Term
GHRH (Growth Hormone Releasing Hormone)
Definition
causes release of growth hormone
Term
Pituitary
Definition
small gland at base of skull
Term
anterior pituitary
Definition
portal system of cappilaries from the hypothalamus (glandular) (releaseing hormone)
-respond to chemical (hormonal) messages sent from the hypothalamus

Hormones: ACTH, TSH, Growth Hormone
Term
posterior pituitary
Definition
neurons from the hypothalamus (neural)
-works with kidneys to regulate free water from the urine back to the blood stream

Hormones: Antidiuretic Hormone
Term
ACTH (Adrenocorticotropin Hormone)
Definition
carried to adrenal gland to release molecules manufactured there
Term
TSH
Definition
Thyroid Stimulating Hormone, regulates basal metabolic rate (metabolism)
-mitochondria of the target cells are caused to increase metabolism in order to create more ATP
Term
Growth Hormone
Definition
anabolism (production of ptn that leads to growth and maturation) - build up
Term
Antidiuretic Hormone
Definition
vasoconstrictor, regulates vascular volume and serum concentration (amount of glucose in blood)
Term
serum concentration
Definition
amount of glucose in the blood
Term
Pineal Gland
Definition
melatonin - antioxidant
-sleep
-anti-aging
Term
Calcitonin
Definition
produced in thyroid
if too much Ca in blood...
-bonds w/ osteoclasts to inhibit resorption of Ca from blood
-stop absorbing as much through digestive tract
-kidney decrease recapture of Ca from urine
Term
Parathyroid
Definition
size of pea
produces PTH
reverses effect of calcitonin
-bonds w/ osteoclasts for more resorption
-absorb more Ca through digestive tract
-kidneys increase recapture of Ca from urine
Term
Thymus
Definition
produces thymosin
-maturation of T cells (immune system)
-decrease as we age
Term
Pancreas
Definition
islets of langerhan
insulin
glucagon
glycogenolysis
glycogneogenesis
Term
Islets of Langerhans
Definition
endocrine cells where insulin is produced
Term
insulin
Definition
release triggered by levels of glucose of nervous system, get glucose out of blood and into cells
Term
glucagon
Definition
opposite effects of insulin, get glucose out of cells and into blood
Term
glycogenolysis
Definition
causes release of stored glucose from the liver to the blood, glycogen when stored
Term
glucogneogenesis
Definition
(formation) from liver, increases production of glucose from other molecules (ex: fat, ptn, lactic acid)
Term
adrenal cortex
Definition
-adrenal gland on top of each kidney
-hormones here originate from cholesterol
-aldosterone, cortisol
-released when stressed to put fuel into blood
-produces precursors of sex related hormones
Term
aldosterone
Definition
homeostasis of Na and K in blood
-give up K to gain Na
-in kidneys
Term
cortisol
Definition
-goes to liver and trigger glucose produced from AA
-breaks stored fat into fatty acids for fuel
-anti-inflammatory properties
Term
kidneys
Definition
renin, aldosterone, angiotensinogen, erythropoietin
Term
renin
Definition
restore flow to kidneys, increase blood volume and blood pressure
Term
angiotensinogen
Definition
ptn synthesis in liver, put into blood causes vasoconstriction and release of aldosterone (homeostasis of Na and K in blood)
Term
erythropoietin
Definition
when oxygen in the blood is low, travels to red bone marrow to effect production of more RBCs
-blood doping
Term
pituitary hormones
Definition
-endorphins are released in both short and long term exertion
-bind to same receptor as morphine to relieve pain
-endogenous morphine (opiate)
-growth hormone, antidiuretic hormone (ADH)
Term
GH
Definition
Growth hormone
-released because of exertion
-increase in blood proportional to intensity
-concentration increases immediately and levels remain high approx. 2 hrs after cessation
Term
GH (part II)
Definition
-anabolic steroid
-causes cell to burn fats before glucose to spare the amount of glucose
-epinephrine and norepinephrine partially responsible
Term
ADH
Definition
Antidiuretic Hormone
-exercise causes release
-recaptures free H2O from urine
-H2O is expanded in so may ways during exercise so body wants to hold onto it
a. respiration (H2O vaporizes w/ breath)
b. keeps blood volume regulated
c. sweating
Term
Adrenal Medulla
Definition
produces epinephrine and norepinephrine
-increase HR, vasodiolation, vasoconstriction, "fight or flight"
Term
Adrenal Gland Hormones
Definition
exercise affects adrenal in much the same way as "fight or flight" when sympathetic is triggered
-norepinephrine + epinephrine released early in exercise, benefit performance
Term
Epinephrine + Norepinephrine
(heart)
Definition
regulate increase in heartrate
-act on receptions at the sinoatrial (SA) Node
-increase heartrate + stroke volume
-blood vessels vasodialate and vasoconstrict
-increase inn cardio output
Term
chronotropism
Definition
increase heart rate
epinephrine and norepinephrine
Term
inotropism
Definition
increase in stroke volume
norepinephrine and epinephrine
Term
Respiration Rate
Definition
change affected by epinephrine and norepinephrine action on CNS
may increase 2x
deliver more O2 and eliminate more metabolic wastes
Term
Training
Definition
-long term exercise decreases baseline level of Epi+Norepi
-less epi + norepi + their effects after long term exercise
-adrenal glands ability to increase hormones can respond to demands sooner
-regression of the medulla in producing hormones is rapid after cessation of exercise
Term
Cortisol (Training)
Definition
-@exercise, >50% of VO2Max, cortisol increases in blood
-trigger glugoneogenesis in liver and muscle
-triggers lipolysis (breaks fat into fatty acids)
-aldosterone (from adrenal) recovers Na + H2O from urine in exchange for K
Term
Pancreatic Hormones
Definition
-glucose consumption - blood + cell rises
-as glucose decreases, pancrease lowers insulin
-receptors for insulin are hypersensitive due to hormones
-more blood supply = increase in insulin and glucose
-long term training = decrease in baseline insulin, but increase in sensitivity
-insulin level affected more by duration than intensity
Term
Glucagon
Definition
-also from pancreas
-increase blood concentration of glucose
1. liver glycogen released
2.gluconeogenesis
3. mobilization of fatty acids
-long term training reduces amount of glucagon
Term
Testosterone
Definition
-anabolic hormone that increases muscle mass
-anaerobic activity causes immediate release
-aerobic activity may reduce the amount of testosterone by 50%
Term
Amenorrhea
Definition
-exercise causes an immediate release of estrogen + progesterone
-prolonged training lowers estrogen + progesterone
-may even lead to amenorrhea
-more prominent in females w/ low body fat
-critical factors: stress + low body fat
-22% body fat required to maintain regular cycles
Term
Intestinal Hormones
Definition
-exercise lowers activity in intestines
-ghrelin
-anaerobic activity lowers level of ghrelin
-suppresses appetite
Term
Ghrelin
Definition
affect appetite
-lowered by anaerobic activity
-suppresses appetite
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