Term
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Definition
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Term
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Definition
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Term
| Intermediate acting insulin |
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Definition
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Term
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Definition
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Term
| Close K+ channel in beta cell membranes, so cell depolarizes triggering of insulin release via increase calcium influx |
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Definition
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Term
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Definition
Tolbutamide
Chlorpropamide |
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Term
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Definition
Glyburide
glimepiride
Glipizide |
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Term
| Insulin type drugs which cause hypoglycemia |
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Definition
| Insulin, Sulfonylureases 2nd gen, Pramlintide( Mimetic) |
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Term
| Hyperglycemic drug which causes disulfiram like effects |
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Definition
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Term
Sulfonylurease that you have to decrease dose in:
Hepatic dysfxn
Renal dysfxn |
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Definition
Hepatic problems= decrease dose of glipizide
Renal problesm= decrease dose glyburide |
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Term
| Increase gluconeogenesis and increase glycolysis in the liver while increasing peripheral glucose uptake |
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Definition
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Term
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Definition
| Lactic acidosis and wt. gain |
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Term
| Increase insulin sensitivity in peripheral tissues. Fat and muscle |
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Definition
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Term
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Definition
| PPAR-gamma nuclear transcription regulator to change gene expression. Increase insulin receptor #'s |
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Term
| Inhibit intestinal brush boarder alpha-glucosidase by delaying sugar hydrolysis and glucose absorption |
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Definition
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Term
| Hyperglycemic med which only decreases glucagon release |
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Definition
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Term
| These hyperglycemic meds increase insulin release and decrease glucagon release |
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Definition
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Term
| Block peroxidase and inhibiting organification of iodide and coupling of thyroid hormone synthesis |
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Definition
Propylthiouracil
methimazole |
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Term
| Action which propylthiouracil has but methimazole lacks |
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Definition
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Term
| Side effects of Propylthiouracil and Methimazole |
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Definition
Skin rashes
agranulocytosis |
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Term
| Which can be used in pregnancy: Propylthiouracil or methimazole |
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Definition
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Term
| 2 drugs used in hypothyrodism or myxedema |
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Definition
Levothyroxine
Triiodothyronine |
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Term
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Definition
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Term
| Somatotropin is used for (4) |
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Definition
GH deficiency
Turner syndrome
Pituitary dwarfs
Osteoporosis |
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Term
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Definition
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Term
|
Definition
Acromegaly
Carcinoid
Gastrinoma
Glucagonoma |
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Term
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Definition
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Term
| Desmopressin used for what (3) |
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Definition
Pituitary (central) diabetes insipidus
Hemophilia A
Von Willibrand disease |
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Term
| ADH antagonist used in SIADH |
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Definition
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Term
| Inhibits leukotriens and prostaglandins by inhibiting phopholipase A2 + expression of COX2 |
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Definition
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Term
| Side effects of Glucocorticoids |
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Definition
Iatrogenic cushingoid syndrome
hyperglycemia
Osteoporosis
Adrenal Insufficiency |
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Term
| GnRH analog and the two different uses |
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Definition
Leuprolide
Pulsatory: Agonist
Continuous: antagonist |
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Term
| Leuprolide use when pulsatory |
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Definition
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Term
| Leuprolide use when constant |
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Definition
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Term
| Agonist at the androgen receptrors |
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Definition
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Term
|
Definition
Hypogonadism
Promotes secondary sex characteristics
Kleinfelters |
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Term
| 5 alpha reductase inhibitor and use |
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Definition
| Finasteride used for BPH and male pattern baldness |
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Term
| A nonsteroidal competitive inhibitor of androgens at the testosterone receptor |
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Definition
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Term
| Inhibits steroid synthesis |
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Definition
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Term
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Definition
| Spironolactone (aldosterone) |
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Term
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Definition
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Term
| Side effects of estrogen use |
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Definition
| endometrial carcinoma and bleeding |
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Term
| Estrogen use Contraindicated in |
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Definition
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Term
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Definition
Hypogonadism
Ovarian failure
Menstrual abnormalities
Contraception
HRT for post menopausal women
Prostate cancer in men |
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Term
| partial agonist @ estrogen receptors in hypothalamus |
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Definition
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Term
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Definition
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Term
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Definition
| Multiple pregnancies (quadruplets) |
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Term
| Antagonist on breast tissue, agonist at bone tissue, and partial agonist at the endometrium |
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Definition
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Term
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Definition
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Term
| SERM used in osteoporosis |
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Definition
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|
Term
| Tamoxifen can cause what cancer |
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Definition
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Term
| Aromatase (-) used in post menopausal women w/breast cancer |
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Definition
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Term
| Side effects of progestin use |
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Definition
Increase LDL/decrease HDL
androgenic (hirsitism/acne)
antiestrogenic
Glucoseintolerance |
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Term
| Competitive inhibitor of progestins at progesterone receptors |
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Definition
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Term
| Mifepristone used with what for what |
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Definition
| Misoprostel (PGE1) and to terminate pregnancy |
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Term
| Contraindications of OC's |
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Definition
Smoking
>35
Thromboembolism
Stroke
Estrogen-dependent tumor |
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Term
| Estrogen and Progestins MOA in OC's |
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Definition
Estrogen=inhibits LH/FSH and estrogen level is always constant and never surges so decrease ovulation
Progesterone= Thickening of cervical mucus limiting access of sperm and inhibits endometrial proliferation. |
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Term
| B2 agonists that relax the uterus, reduce premature uterine contractions |
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Definition
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Term
| alpha1-antagonist used to treat BPH by inhibiting smooth muscle contraction. Also what alpha receptor is it selective for |
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Definition
| Tamsutosin alpha 1a or 1d receptors |
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Term
| Inhibit cGMP phosphodiesterase, causing smooth muscle relaxation in the corpus cavernosum, Increase blood flow, increase erection |
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Definition
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Term
| Side effects of Sildenafil |
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Definition
Flushing
Blue Green vision
Life threateing Hypotension when given with NITRATES |
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Term
| Synthetic androgen that acts as a partial agonist @ androgen recptors |
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Definition
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Term
|
Definition
Endometriosis
Hereditary angioedema |
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