Term
| What are some challenges to the screening of endocrine disorders? |
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Definition
Sensitivity to pick up the small levels of hormones
Specificity to prevent cross reactivity
Multiple Hormone forms from Post-trans Mod
Bound vs Free Forms
Homone Fluctuations
Multiple levels causes same clinical disease |
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Term
| What is the most commonly used endocrine testing |
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Definition
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Term
| How is thyroid screening assessed? |
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Definition
TSH levels, If abnormal do FT4
T3, If TSH low and FT4 normal
Anti-Thyroid substances, If TSH elevated
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Term
| How is Adrenocortical Hyperfunctioning assessed? |
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Definition
24 hr free Cortisol
Primary: if low ACTH and High Cortisol
Secondary: if high ACTH and High Cortisol
Ectopic ACTH production does not respond to dexamethasone |
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Term
| What are some common casues of Hypercalcemia |
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Definition
Vit D Intoxication
Primary and Secondary Hyperparathyroid
Sarcoid
Myloma
Excessive Intake
Hyperthyroid
Immobilization |
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Term
| What are some causes of Hypocalcemia |
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Definition
Hypoparathyroidism
Vit D Deficiency
Malabsorption
Pancreatitis
Transfusion |
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Term
| How do you screen for a Pheochromocytoma? |
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Definition
| Urinalysis for Norepinephrine, Epinephrine, VMA levels |
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Term
| What are some common factors that alter catecholamine production? |
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Definition
Caffeine, Nuts, Bananas
MAO-Inhibitors
Alpha-Methyldopa
Dopamine
Stress
Isoproterenol
Quinidine
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