Term
crystalloid isotonic solution |
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Definition
initial fluid of choice for volume resuscitation |
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Term
crystalloid hypotonic solution |
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Definition
fluid of choice for maintenance fluids |
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Term
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Definition
fluid of choice for intravascular volume resuscitation |
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Term
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Definition
normal lab value range for K |
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Term
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Definition
normal lab value range for Mg |
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Term
PO route not preferred for replacement due to: amount of replacement needed usually not tolerated PO due to ADRs (diarrhea) saburable GI absorption -> limits amount that can be given in one PO dose slow onset of action |
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Definition
identify dose limiting ADRs of oral Mg therapy |
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Term
1 g/hr or slower the slower the rate of Mg administration the more that is absorbed by the kidneys the kidneys respond to changes in serum concentrations - if rapid increase in [Mg] the kidneys will excrete more Mg in response |
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Definition
specify the ideal rate for administering IV Mg |
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Term
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Definition
specify normal lab value range for phosphorus |
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Term
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Definition
specify normal lab value range for Ca (unionized) |
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Term
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Definition
hallmark sign of hypocalcemia |
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Term
corrected calcium = serum Ca + 0.8(4-albumin) |
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Definition
corrected calcium equation |
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Term
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Definition
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Term
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Definition
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Term
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Definition
normal range for bicarbonate |
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Term
anion gap = Na - (Cl + HCO3) anion gap > 12 = anion gap acidosis |
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Definition
equation to calculate anion gap |
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Term
total body water = 0.6 x actual body weight |
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Definition
equation for total body water |
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Term
crystalloid isotonic solution |
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Definition
initial fluid of choice for volume resuscitation expands the extracellular fluid |
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Term
crystalloid hypotonic solution |
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Definition
good for maintenance fluids good for IV medication admixtures distributes into extracellular and intracellular compartments not useful for rapid intracellular volume expansion due to greater distribution into intracellular fluid compartments more than isotonic fluids |
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Term
crystalloid hypertonic solution |
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Definition
limited use due to risk of excessive increase in plasma sodium concentration leading to osmotic demyelination stays in ECF and pulls water from the ICF used for - symptomatic hyponatremia and a treatment to decrease intracranial pressure |
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Term
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Definition
most rapid intravascular volume expansion remains primarily in the intravascular fluid compartment and pulls additional fluid into the intravascular space by oncotic pressure |
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Term
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Definition
indication -> intravascular volume resuscitation ADRs: pulmonary edema, hypocalcemia, anaphylaxis |
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Term
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Definition
indication -> shift fluid from intracellular and interstitial compartments to the intravascular space used in patients with hypovolemia with interstitial edema (hypotention during hemodyalysis, CHF) |
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Term
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Definition
indication -> volume resuscitation least used colloid due to ADRs: dose related bleeding tendencies, acute renal failure |
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Term
mild-moderate hypovolemia: 1-3 x basal fluid requirements severe or hemodynamic instability: 500-1000 ml boluses until the patient is stable, then 2-3 x maintenance rate |
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Definition
fluid replacement rates for mild-moderate hypovolemia and severe or hemodynamic instability |
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Term
general: N/V, constipation, muscular weakness, myalgias, cramps cardiac: EKG changes, life-threatening arrhythmias, heart block, ventricular fibrillation, lowered threshold for digoxin toxicity paralysis, respiratory depression, rhabdomyolysis |
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Definition
signs/symptoms of hypokalemia |
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Term
general: N/V, constipation, muscular weakness, myalgias, cramps, muscle twitching cardiac: EKG changes, life-threatening arrhythmias ascending paralysis |
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Definition
signs/symptoms of hyperkalemia |
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Term
increased GI elimination: vomiting, NG emptying enhanced fecal elimination: diarrhea, oral sorbitol, sodium polystyrene sulfate enhanced renal elimination: diuretics (loops>thiazides), hypomagnesemia, aminoglycosides, high dose penicillins, amphotericin B (damages renal tubules), corticosteroids, platinum based chemotherapy intracellular shift of K: insulin, metabolic alkalosis, beta-agonists, theophylline |
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Definition
etiologies of hypokalemia |
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Term
increased GI intake: dietary, K supplements, IV fluids with K, TPN extracellular shift: metabolic acidosis, beta-blockers, digoxin overdose, succinyl choline, muscle injury, hemolysis decreased urinary excretion: RENAL FAILURE, K sparing diuretics, NSAIDs, hypoaldosteronism, ACEi/ARBs, trimethoprim |
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Definition
etiologies of hyperkalemia |
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Term
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Definition
10 mEq of K = how much increase in serum K? |
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Term
10 mEq/hr / 10 mEq/hr 10 mEq/hr / 40 mEq/hr |
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Definition
max rate for peripheral/central IV K, not on EKG = ? max rate for peripheral/central IV K, on EKG = ? |
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Term
MOA: stabilizes myocardium by antagonizing cardiac conduction abnormalities onset: 1-2 minutes |
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Definition
MOA and onset of action of IV calcium used for cardioprotection when hyperkalemic |
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Term
MOA: increases pH (metabolic alkalosis) and causes K to shift intracellularly onset: 30 minutes good for patients who also have metabolic acidosis |
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Definition
MOA and onset of sodium bicarbonate used for intracellular shift of K when hyperkalemic. |
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Term
MOA: insulin shifts K into cells and dextrose prevents hypoglycemia and increases natural insulin release onset: 15-45 minutes should be given by IV route |
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Definition
MOA and onset of insulin +/- dextrose used for intracellular shift of K when hyperkalemic |
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Term
MOA: stimulates Na/K/ATPase pump to pump K into cell onset: 30 minutes |
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Definition
MOA and onset of albuterol used for intracellular shift of K when hyperkalemic |
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Term
MOA: increase K excretion in urine onset: 5-15 minutes |
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Definition
MOA and onset of loop diuretics used for increase K excretion when hyperkalemic |
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Term
MOA: binds to K in the GI tract and removes it in the feces onset: 1 hour |
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Definition
MOA and onset of sodium polystyrene sulfonate (Kayexalate) used for increased K excretion when hyperkalemic |
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Term
reduced intake: alcoholism (Mg is a cofactor in alcohol metabolism, malnutrition), malnutrition decreased GI absorption: pancreatic insufficiency, short bowel syndrome, malabsorption syndrome increased GI losses: vomiting, excessive laxative use, NG suctioning, prolonged diarrhea enhanced renal elimination: loop diuretics, amphotericin b (damage tubules), cisplatin (damage tubules), nephrotic syndrome, renal tubule acidosis, hyperthyroidism, aldosteronism intracellular shift: diabetic ketoacidosis, glucose, insulin |
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Definition
etiologies of hypomagnesemia |
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Term
renal insufficiency excess Mg intake - PO, IV, medications, TPN |
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Definition
etiologies of hypermagnesemia |
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Term
neuromuscular: muscle weakness, muscle twitching, paresthesias, tetany, depression, hyperreflexia, psychosis, seizures cardiovascular: EKG changes, TORSADES DE POINTS, sensitivity to digoxin |
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Definition
signs/symptoms of hypomagnesemia |
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Term
weak, lethargic, tired, body slows down Mg 4-6 mg/dL: hypotension, lethargy, bradycardia, drowsiness, EKG abnormalities Mg 6-10 mg/dL: hyporeflexia, coma, drowsiness, hypocalcemia Mg > 10 mg/dL: respiratory depression, heart block, asystole |
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Definition
signs/symptoms of hypermagnesemia |
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Term
amount of replacement needed usually not tolerated PO due to ADRs -> diarrhea saturable GI absorption -> limits amount that can be given in one PO dose slow onset of action |
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Definition
dose limiting ADRs of oral Mg |
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Term
1 g/hr or slower the slower the rate, the more that is absorbed by the kidneys the kidneys respond to rapid changes in serum [Mg] (kidneys will excrete Mg in response to elevated serum levels) |
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Definition
ideal rate for IV administration of Mg |
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Term
MOA: used to stabilize cardiac and neuro membranes; temporary treatment, does not decrease Mg levels |
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Definition
MOA of IV calcium gluconate used for cardioprotection when hypermagnesemic |
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Term
MOA: dilutes serum Mg and may stimulate renal elimination if ARF due to hypovolemia |
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Definition
MOA of volume expansion with 0.9% NaCl used for cardioprotection and increased Mg excretion when hypermagnesemic |
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Term
MOA: increased renal elimination of Mg and may stimulate urine output in oliguric renal failure |
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Definition
MOA of loop diuretics used for increased Mg excretion when hypermagnesemic |
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Term
oral: MgCl, magnesium oxide (more elemental Mg), MgOH (milk of magnesia); considerations - diarrhea, divided doses IV: magnesium sulfate; give IV slowly to avoid spike in concentration |
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Definition
oral and IV products for hypomagnesemia |
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Term
decreased GI absorption: phosphate-binding medications, chronic diarrhea, sucralfate (phos binder), steaorrhea (fatty diarrhea), vitamin D deficiency, calcium carbonate increased urinary excretion: hyperparathyroidism, metabolic acidosis, sodium bicarbonate, diuretics, volume expansion, renal transplant, burn recovery, malignant neoplasms, glucocorticoids internal redistribution: refeeding syndrome, chronic alcoholism, respiratory alkalosis, insulin, recovery from diabetic ketoacidosis, sepsis |
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Definition
etiologies for hypophosphatemia |
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Term
patients with renal insufficiency, especially CKD are at high risk increased GI intake: dietary including TPN, vitamin D intoxication, phosphate-containing enemas extracellular shift: tumor lysis syndrome, rhabdomyolysis, bowel infarction, hemolysis, diabetic ketoacidosis (prior to treatment) decreased urinary excretion: RENAL FAILURE, hypoparathyroid, bisphosphonates, hypomagnesemia |
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Definition
etiologies of hyperphosphatemia |
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Term
general: muscle weakness, irritability, dysphagia, ileus, confusion, numbness severe: impaired diaphragm contractility and acute respiratory failure, paralysis, cardiac arrhythmias and decreased cardiac contractility, seizures and neurological dysfunction, tissue hypoxia and rhabdomyolysis, hemolytic anemia |
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Definition
signs/symptoms of hypophosphatemia |
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Term
most patients are asymptomatic unless rapid onset soft tissue calcifications when Ca x Phos > 55 chronically moderate-severe: N/V/D, lethargy, seizures, renal failure due to ca-phos precipitations in kidney |
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Definition
signs/symptoms of hyperphosphatemia |
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Term
dairy products are high in phos many products contain K, must also assess patients K levels common ADR = diarrhea divided daily doses TID or QID choose products based on restriction of K or Na common initial dose = 30-60 mmol phos po divided doses |
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Definition
oral phosphate products considerations |
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Term
3 mmol phos and 4.4 mEq K per mL |
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Definition
ratio of K to phos in potassium phosphate IV (used for hypophosphatemia when patient has hypokalemia) |
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Term
3 mmol phos and 4 mmol Na per mL |
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Definition
ratio of Na and phos in sodium phosphate IV (used for hypophosphatemia if patient is at risk for developming hyperkalemia) |
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Term
treat/reverse underlying cause IV Ca to resolve symptoms of hypocalcemia if Ca not resolving symptoms then hemodialysis is required |
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Definition
treatment of acute hyperphosphatemia with symptoms of hypocalemia |
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Term
disease states: hypoparathyroidism, malignancies, rhabdomyolysis, chronic renal insufficiency, hyperphosphatemia, hypomagnesemia, acute pancreatitis, sepsis, vitamin D deficiency medications: phenytoin, phenobarbital, cholestyramine, laxatives others: blood products - due to citrate anticoagulant binding Ca |
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Definition
etiologies of hypocalcemia |
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Term
disease states: hyperparathyroidism, malignancies, immobilization, thyroxoicosis, vitamin D intoxication, renal failure, renal transplant, adrenal insufficiency medications: thiazide diuretics, calcium supplements, lithium, Al/Mg antacids, theophylline, tamoxifene, estrogens |
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Definition
etiologies of hypercalcemia |
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Term
acute: muscle cramps and paresthesias, laryngeal spasms, bradycardia, hypotension, arrhythmias, seizures, TETANY = HALLMARK SIGN OF HYPOCALCEMIA chronic: depression, anxiety, memory loss, confusion, hair loss, grooved/brittle nails, exzema, dermatitis |
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Definition
signs/symptoms of hypocalcemia |
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Term
acute: constipation, N/V, anorexia, PUD, oliguric renal failure, nephrolithiasis/obstruction, mild drowsiness, progressing weakness, depression, lethargy, stupor, coma, ventricular arrhythmias chronic: metastatic calcifications, nephrolithiasis (kidney stone), chronic renal insufficiency |
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Definition
signs/symptoms of hypercalcemia |
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Term
corrected Ca = serum Ca + 0.8(4-albumin) |
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Definition
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Term
CaCl = central line only (extravasation risk) Ca gluconate = safer than Cl, contains less elemental Ca than Cl, can be used in peripheral or central line |
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Definition
compare/contrast CaCl and Ca gluconate |
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Term
corticosteroids and IV bisphosphonates not calcitonin |
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Definition
what treatments for hypercalcemia can be used in cases of malignancy? |
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Term
central stimulation of respiration (hyperventilation): pain, anxiety, fever, brain tumors, stroke/TIA, head trauma, pregnancy peripheral stimulation of respiration: pulmonary embolism, CHF, altitude, asthma, pulmonary shunts, hypotension, pneumonia, poor lung compliance (stiff lungs) medications: salicylates, nicotine, thyroid hormone, catecholamines other: mechanical hyperventilation, hepatic cirrhosis, gram-negative sepsis |
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Definition
etiologies of respiratory alkalosis |
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Term
acute: impaired profusion - massive pulmonary embolism, cardiac arrest impaired ventilation - severe pulmonary edema, severe pneumonia (muscles worn out) CNS depression - medications (opioids, benzodiazepines, alcohol), trauma, stroke chronic: impaired ventilation - COPD, chest muscle wall problems CNS - obstructive sleep apnea, tumors, stroke |
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Definition
etiologies for respiratory acidosis |
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Term
sodium chloride sensitive (urine Cl < 10 mmol/L) - Cl is a base, if Cl gets low the body holds on to bicarbonate instead and leads to alkalosis: GI losses, diuretics (get rid of K and Na and Cl follows), cystic fibrosis, excessive bicarbonate therapy sodium chloride resistant (urine Cl > 10 mmol/L): excessive mineralocorticoid activity (hyperaldosteronism, Cushing's), excessive black licorice intake other: alkali administration, massive blood transfusion (due to citrate), carbohydrate refeeding after starvation, large doses or penicillin |
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Definition
etiologies of metabolic alkalosis |
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Term
non-anion gap: due to excessive loss of bicarbonate accompanied by an increase in renal reabsorption of Cl, diarrhea, GI fistula, ileostomy, carbonic anhydrase inhibitors, renal tubular acidosis anion gap: due to excessive organic acid accumulation, MUDPILES, methanol, uremia, diabetic ketoacidosis, polyethylene glycol, ischemia, lactic acidosis, ethylene glycol, salicylate intoxication, 3 main causes - lactic acidosis, ketoacidosis, renal failure |
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Definition
etiologies of metabolic acidosis |
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Term
hypophosphatemia hypocalcemia hypokalemia |
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Definition
electrolyte disorders that accompany respiratory alkalosis |
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Term
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Definition
electrolyte disorders that accompany respiratory acidosis |
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Term
hypophosphatemia hypocalcemia hypokalemia |
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Definition
electrolyte disorders that accompany metabolic alkalosis |
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Term
hyperkalemia hyperglycemia |
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Definition
electrolyte disorders that accompany metabolic acidosis |
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Term
anion gap: treat the underlying cause. DO NOT ADMINISTER SODIUM BICARBONATE acute non anion gap: GOAL - to increase bicarbonate, not to normalize pH; calculate base deficit, start by replacing 50% of base deficit with IV sodium bicarbonate over > 30 minutes, 1 amp bicarb = 50 mEq NaHCO3 (3 amps in D5W = 150 mEq Na = isotonic) |
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Definition
how to treat anion gap and non anion gap metabolic acidosis |
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