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Endocrine Drugs
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33
Pharmacology
Undergraduate 1
02/04/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Rapid-Acting Insulin Drugs
Definition

Taken in morning or before eating.

Can start working to lower blood glucose in 15 minutes.

Therapeutic effects last 2-12 hrs.

Term
Examples of Rapid-Acting Insulin Drugs
Definition

Humulin R:  Recombinant DNA

Novolin R:  Recombinant DNA

Insulin Lispro(Humalog):  Insulin Analog Drug

 

Term
Intermediate-Acting Insulin Drug
Definition

Onset within 1-2 hours.

Theraputic Effects last for 24 hours.

Two types:  NPH Insulin Drugs

Lente Insulin Drugs

Term

Intermediate-Acting Insulin Drug

NPH Insulin Drugs

Definition

Insulin Drug with Protamine and Zinc.

Humulin N

Novolin N

Term

Intermediate-Acting Insulin Drugs

Lente Insulin Drug

Definition

Lente Iletin II:

slows down the onset action of insulin

Term

Rapid-Acting Insulin Drugs

Derived from pig pancreas

Definition
Regular Iletin II
Term

Rapid-Acting Insulin Drug

Insulin Analog Drug

Definition

Lente Insulin Drugs

Different size insulin crystals

Insulin Aspart(Novolin R)

Insulin Glulisine(Apidra)

Insulin Lispro(Humalog)

Term

Long-Acting Insulin Drugs

(Ultralente Insulin)

Definition

Large insulin crystals containing added zinc.

Theraputic effects do not take effect for an hour.

Therapeutic effects lasts a full 24 hours with one dose.

Term

Long-Acting Insulin Drug

Insulin Analog Drugs

 

Definition

Insulin Detemir(Levemir)

Insulin Glargine(Lantus)

Term

Combination Insulin Drugs

 

Definition

Mixture of Intermediate-Acting Drugs

(NPH Insulin Drug or Insulin Analog Drug)

And

(Rapid-Acting Insulin Drug)

Term
Combination Insulin Drugs
Definition

Humalog Mix 75/25

Humulin 50/50

Humulin 70/30

Novolin 70/30

NovoLog mix 70/30

 

Term
Oral Antidiabetic Drug
Definition

Stimulates the beta cells of the pancreas to produce more insulin

Increases the number of insulin receptors making cells non-resistant to the effects of insulin

Term

Sulfonylurea Oral Antidiabetic Drug

 

Definition

Stimulates the beta cells of the pancreas to produce more insulin

1st generation:  1950's

generic name suffix:  amide 

2nd generation:  1970's

Generic name suffix: ide

Term
Thiazolidinedione Oral Antidiabetic Drug
Definition

Maintains normal levels of blood glucose without increasing insulin production.

pioglitazone(Actos)

rosiglitazone (Avandia)

Term
Sulfonylurea oral Antidiabetic Drug
Definition

Chlorpropamide(Diabinese)

Glimepiride(Amaryl)

Glipizide(Glucotrol, Glucotrol XL)

Glyburide(DiaBeta, Micronase)

Tolazamide

Tolbutamide(Orinase)

Term
Meglitinide Oral Antidiabetic Drugs
Definition

Stimulates the beta cells of the pancreas to produce more insulin.

Naeglinide(Starlix)

Repaglinide(Prandin)

 

Term
Alpha-Glucosidase Inhibitor Oral Antidiabetic Drugs
Definition

Inhibits certain enzymes that digest carbohydrates

Less glucose enters the blood keeping blood glucose levels low.

Acarbose(Precose)

Miglitol(Glyset)

 

Term
Biguanide Oral Antidiabetic Drugs
Definition

Decreases absorption of glucose from Intestines

Suppresses stored glucose from liver

Improves ability of cells to use pancreas produced insulin

No risk of developing Hypoglycemia

Term
Biguanide Oral Antidiabetic Drugs
Definition

Metformin

(Glucophage, Glucophage XR)

Term
DPP-4 Inhibitor Oral Antidiabetic Drugs
Definition

Prolongs action of hormones that normally stimulates the beta cells to produce more insulin.

Sitagliptin (Januvia)

Term
Combination oral Antidiabetic Drug
Definition
Avandamet (Metformin, Rodiglitazone)
Term
Incretin mimetic Antidiabetic Drug
Definition

Stimulates beta cells of pancreas to produce insulin when blood glucose levels are high.

Given by Subcutaneous injection.

Derived from Gila Monster Saliva.

Exenatide (Byetta)

Term
Amylin Analog Antidiabetic Drug
Definition

Slows the rate of food leaving stomach

Suppresses the release of stored glucose from liver

Decreases appetite

Treats Type 1 and Type 2 Diabetes

Pramlintide (Symlin)

Term
Bile Acid Sequestrant Antidiabetic Drug
Definition

Improves Blood Glucose control in Type 2

Treats elevated levels of cholestrol

Colesevelam (WelChol) 

Term
Drugs for Hyperthyroidism
Definition

Inhibits production of  T3 and T4 in Thyroid gland.

Distroys  benign & Cancerous Tyroid tissue.

Iodine (ThyroShield)

Methimazole (Tapazole)

Propylthiouracil

Sodium Iodide 131 (Iodotope)

 

Term
Drugs for Hypothyroidism
Definition

Decrease levels of T3 and T4 Hormones

Supplements existing hormones snythetically

T3 only:  Liothyronine (Cytomel, Triostat)

T4 only:  Levothyroxine (Levothroid, Synthroid)

Both T3 and T4: Desiccated Thyroid

Liotrix (Thyrolar)

Term
Growth Hormone
Definition

Decreases amount of Growth hormone.

Antibodies against Growth hormone.

Decreases amount of insulin.

Mecasermin(Increlex, Iplex)

Sermorelin (Geref)

Somatropin (Humatrope, Nutropin)

Somatrem (protropin)

Term
Drugs for Acromegaly
Definition

Decreases the production of growth hormone in anterior pituitary gland.

Bromocriptine (Parlodel)

Lanreotide (Somatuline Depot)

Octreotide (Sandostatin)

Pegvisomant (Somavert)

Term
Drugs for Diabetes Insipidus
Definition

Replaces levels of ADH.

Desmonpressin (DDAVP)

Vasopressin (Pitressin)

Term
Drugs for Cushing's Syndrome
Definition

Inhibits Pregnenolone.

Aminoglutethimide (Cytadren)

Term

Corticosteroid Drug

Glucocorticoids

Definition

Replaces Cortisol.

Treats Addison's Disease, MS, Lupus and RA.

Cortisone

Fludrocortisone (Florinef)

hydrocortisone (Cortef)

Decadron, Solu-Medrol

Deltasone

Term
Anabolic Steroid Drug
Definition

Changes the balance between Anabolism and Catabolism in the body.

Counteracts loss of muscle mass in Aids patients.

Treats bone pain in Osteoporosis.
Treats lack of growth in Turner Syndrome.

Schedule III Drug

Oxandrolone (Oxandrin)

Oxymetholone (Anadrol-50)

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