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Endocrine Drugs
BLock 2 Final Drug List
71
Medical
Graduate
02/18/2012

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Term
17-beta estradiol
Definition
Naturally occurring estrogen
For primary hypogonadism; Menopausal therapy; Suppression of ovarian fxn (acne, hirsutism, amenorrhea); Contraception
Term
Acarbose
Definition
alpha-glucosidase inhibitor
Reduces conversion of starch to glucose
Reduces postprandial glucose
Term
Aminoglutethimide
Definition
Anti-steroid
Blocks aromatase, p450sc (at high doses)
For Cushing's Syndrome
Causes hypothyroid?
Term
Anastrazole
Definition
Aromatase Inhibitor
For Advanced BRCA in postmenopausal women
Term
Aspart Insulin
Definition
Rapid Acting Insulin
Onset 5-15 min
DUration 3-4 hours
Term
Betamethasone
Definition
Long-acting glucocorticoid
ANti-inflammatory
Term
Bromocriptine
Definition
DA Agonist
For Hyperprolactinemia; Acromegaly; Parkinson's disease
SUppresses PRL and GH
Term
Clomiphene
Definition
SERM - Partial estrogen agonist
Inhibits negative feedback on hypothalamus to increase gonadotropin production
Ovarian stimulation
1st line for ovarian stimulation (PCOS, IVF, infertility)
Term
Conjugated Estrogens
Definition
Naturally occurring estrogen
For primary hypogonadism; Menopausal therapy; Suppression of ovarian fxn (acne, hirsutism, amenorrhea); Contraception
Term
Cosyntropin
Definition
Synthetic ACTH
Use for ACTH stimulation test to diagnose Addison's
Term
Desogestrel
Definition
Synthetic C-19 Progestin
For Contraception; Endometriosis; DYsmenorrhea
Term
Detemir
Definition
Long Acting Insulin
Onset 1-2 hours
Duration 24 hours
Term
Dexamethasone
Definition
Long-acting glucocorticoid
Anti-inflammatory
Suppresses Cortisol by decreasing ACTH
To test for Cushings
Term
Doxazosin
Definition
alpha1 Adrenergic receptor antagonist
For BPH; Urinary Retention; HTN
May cause retograde ejactulation
Term
Drospirenone
Definition
Synthetic C-17 Progestin
For Contraception; Endometriosis; Dysmenorrhea
- Spironolactone analog that acts as aldosterone antagonist
Term
Dutasteride
Definition
5 alpha-reductase Inhibitor
For BPH; Urinary retention
Contraindication: Women and Children
Term
Ethinyl Estradiol
Definition
Synthetic Estrogen
For primary hypogonadism; Menopausal therapy; Suppression of ovarian fxn (acne, hirsutism, amenorrhea); Contraception
Term
Exenatide
Definition
Incretin-based
Analong of GLP-1 to reduce post-meal glucose excursions.
Increases glucose-mediated insulin release, lowers glucagon levels, slows gastric emptying
Term
Finasteride
Definition
5 alpha-reductase Inhibitor
For BPH; Urinary retention
Contraindication: Women and Children
Term
Fludrocortisone
Definition
Synthetic Aldosterone (mineralocorticoid)
Salt-retaining
Term
Flutamide
Definition
Competitive Androgen receptor antagonist
For Prostate Cancer
Reversible hepatic toxicity
Term
Glargine
Definition
Long Acting Insulin
Onset 1-2 hours
Duration 24 hours
Term
Glipizide/Glyburide/Glimepiride
Definition
Sulfonylureas
Insulin Secretagogues (close K/ATP channels)
Pts with functioning Beta cells
Term
GnRH
Definition
SYnthetic GnRH
For Ovarian stimulation/Ovulation in duction; Hypothalmic amenorrhea
Term
Gonadotrophs
Definition
LH Agonists
For Hypogonadotropic Hypogonadism
Term
Goserelin
Definition
GnRH Agonist
For Androgen suppression - Prostate Cancer; Mitigates precocious puberty
Leads to hypogonadism
Term
Hydrocortisone
Definition
Synthetic Cortisol
Term
Insulin Drugs that make you gain Weight
Definition
All synthetic Insulins
Sulfonylureas
TZDs
Term
Iodide
Definition
Tx for hyperthyroidism (to cool patients down)
Inhibits proteolysis of thyroglobulin
Temporary use
Term
Letrozole
Definition
Aromatase Inhibitor
For Advanced BRCA in postmenopausal women
Term
Leuprolide
Definition
GnRH Agonist
For Androgen suppression - Prostate Cancer; Mitigates precocious puberty
Leads to hypogonadism
Term
Levonorgestrel
Definition
Synthetic C-19 Progestin
For Contraception; Endometriosis; DYsmenorrhea
Term
Levothyroxine
Definition
Pure, synthetic T4
DOC for hypothyroidism
Term
Liotrix
Definition
Combination of T4 and T3
For hypothyroidism
Term
Lispro Insulin
Definition
Rapid Acting Insulin
Onset 5-15 min
DUration 3-4 hours
Term
Lyothryonine
Definition
Pure, synthetic T3
For hypothyroidism
Expensive
Term
Medroxyprogesterone Acetate
Definition
Synthetic C-21 Progestin
For Contraception; Palliative Tx of endometrial carcinoma
Term
Megestrol Acetate
Definition
Synthetic C-21 Progestin
For Contraception; Palliative Tx of endometrial carcinoma
Term
Mestranol
Definition
Synthetic Estrogen
For primary hypogonadism; Menopausal therapy; Suppression of ovarian fxn (acne, hirsutism, amenorrhea); Contraception
Term
Metformin
Definition
Biguanide
Reduces gluconeogenesis
No weight gain
Term
Methimazole
Definition
Thinamide
DOC for hyperthyroidism (it's antithyroid)
Blocks tyroid hormone formation
Dont use in 1st trimester
Risk: obstructive jaundice, agranulocytosis, vasculitis, aplastic anemia
Term
Methyltestosterone
Definition
Androgen receptor agonist
For Androgen hormone replacemtnt therapy; Osteoporosis; Growth stimulation in children; Gynecologic disorders
Term
Metyrapone
Definition
Blocks cortisol synthesis
Inhibits p450c11
Use to diagnose adrenal insufficiency
Term
Micronized Progesteron
Definition
Naturally-occurring progestin
For Contraception (thickend cervical mucus, inhibits GnRH secretion)
Term
Mifepristone
Definition
Progesterone Antagonist
For Post-coital contraception; Abortafacient (<7 weeks)
- Prevent ovulation by suppressing LH surge
- Impairs blastocyst implantation
Term
NPH Insulin
Definition
Intermediate acting insulin
Onset 1-3 hours
Duration 16-24 hours
Term
Norethindrone
Definition
Synthetic C-19 Progestin
For Contraception; Endometriosis; DYsmenorrhea
Term
Norgestimate
Definition
Synthetic C-19 Progestin
For Contraception; Endometriosis; DYsmenorrhea
Term
Norgestrel
Definition
Synthetic C-19 Progestin
For Contraception; Endometriosis; DYsmenorrhea
Term
Pioglitizone
Definition
Thiazolidinedione (TZD)
PPAR-gamma gene expression. Reduces insulin resistance. Insulin Sensitizer
Term
Potassium Perchlorate
Definition
Antithyroid
For hyperthyroidism
Ionic inhibitor
Term
Pramlintide
Definition
Amylin Analog - for DM
Reduces post-meal glucose excursions, lowers glucagon levels, slows gastric emptying, decreases appetite
Term
Prazosin
Definition
alpha1 Adrenergic receptor antagonist
For BPH; Urinary Retention; HTN
May cause retograde ejactulation
Term
Prednisone
Definition
Short-medium acting Glucocorticoid
Anti0inflammatory, salt-retaining
Term
Proprylthiouracil (PTU)
Definition
Thionamide
For Hyperthyroidism (It's antithyroid)
BLocks TPO (Oxidation of iodide)
Use in 1st trimester of pregnancy
Risk: agranulocytosis, rashes, hepatitis, vasculitis, aplastic anemia, hepatic necrosis
Term
Radioiodine
Definition
Safe, effective ablative therapy for hyperthyroidism (goiter)
- Onset in 6-12 weeks
- Full effect in 3-6 months
Never use during pregnancy
Term
Raloxifene
Definition
SERM
Prevention of osteoporosis in postmenopausal women; Prophylaxis for breast cancer
Agonist in bone, Antagonist in breast/Endometrium
Risk of DVT
Term
Recombinant FSH
Definition
Gonadotropin - mimics FSH
For ovarian stimulation
Term
Regular Insulin
Definition
Regular Acting Insulin
Onset 30 min
Duration 5-8 hours
Term
Repaglinide
Definition
Glitinide
Insulin secretagogue, increases glycogen/fat/protein formation, gene regulation
No weight gain
Term
Sildenafil/Tadalafi/Vardenafil
Definition
Type 5 PDE Inhibitors
For Erectile Dysfunction and pulmonary HTN
Contraindication: Nitrates
Term
Sitagliptin
Definition
Incretin-based
DPP-4 Inhibitor - BLocks degradation of GLP-1.
Reduced post-meal glucose, increases glucose-mediated insulin release, lowers glucagon levels, slows gastric emptying, decreases appetite
Term
Spironolactone
Definition
Aldosterone receptor blocking agent
For primary hyperaldosteronism
Term
Tamoxifen
Definition
SERM
For ER+ BRCA and prophylaxis
Antagonist in breast, Agonist in uterus
Risk of endometrial hyperplasia and DVT
Term
Tamsulosin
Definition
alpha1A Adrenergic receptor antagonist (Most specific for bladder smooth muscle)
For BPH; Urinary Retention
May cause retograde ejactulation
Term
Terazosin
Definition
alpha1 Adrenergic receptor antagonist
For BPH; Urinary Retention; HTN
May cause retograde ejactulation
Term
Toremiphene
Definition
SERM
For Advanced, metastatic BRCA
Antagonist in breast, Agonist in uterus
Term
Ultralente Insulin
Definition
Very Long ACting Insulin
Onset 4-6 hours
Duration 32+ hours
Term
hCG
Definition
Gonadotropin - mimics LH
For Ovarian stimulation
Term
hMGs
Definition
Gonadotropin - mix of FSH and LH
For Ovarian stimulation
Term
hMGs with hCG
Definition
Gonadotropin - mix of FSH, LH, hCG
For ovarian stimulation
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