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Endocrine Disorders
Uh endocrine disorders duh
28
Medical
Professional
03/07/2013

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Term
Grave's Disease
Definition
Elevated Thyroid Hormone
Decreased TSH
Term
Thyroid Storm
Definition
Precipitated by Stress
Anxiety, Cardiac Failure, Hypotension
Term
Hashimoto's Thyroiditis
Definition
Goiter
Hypothyroidism with bouts of Hyperthyroidism
Autoimmune T-cell Disease
Term
Hypothyroidism
Definition
#1 Cause is damage to the gland
Secondary: pituitary/hypothalamic disease
Term
Congenital Hypothyroidism (Cretinism)
Definition
Jaundice, Hypotonia, Enlarged Tongue, CNS damage
Term
Clinical Hypothyroidism
Definition
Lethargy, Cold Intolerance, Cramping, Weight Gain, Hypotension.
Myxedema: mucopolysaccharides in tissues (puffiness)
Term
Myxedema Coma
Definition
Extreme Hypothyroidism
BP and HR get low
Term
MEN-1
Definition
Pituitary, Parathyroid, Pancreas-Islet
Adenomas
Term
MEN-2A
Definition
Younger Individuals
Thyroid Medullary Carcinoma, Pleochromatacytoma, Parathyroid Adenoma
Term
MEN-2B
Definition
Thyroid Medullary Carcinoma, Pleochromatacytoma, Parathyroid Adenoma
*with presentation of neuromas on lips and tongue
Term
Primary Adrenal Insufficiency
Definition
Autoimmune or Infection of Adrenals
Term
Secondary Adrenal Insufficiency
Definition
Hypothalamus or Pituitary Problems with ACTH
Long Term corticosteroid use
Term
Addison's Disease
Definition
Autoimmune destruction of Adrenal Cortex
Lack Glucocorticoids and Meneralcorticoids
Hypotension, Dehydration, Decreased Blood Glucose, Hyperpigmentation
Term
Cushing's
Definition
ACTH secreting Tumor/Chronic corticosteroid use
Moon Face, Buffalo Hump, Fat deposits
Poor Wound Healing, Osteoporosis
Term
Chronic Stress
Definition
Osteoporosis and Metabolic Syndrome
Inhibitory effects on sex steroids and GH
(GH inhibited by somatostatin and cortisol)
Cortisol Blocks T4->T3
Term
Stress Hyper-activation
Definition
Depression, Anorexia, OCD, Panic, Alcoholism
Term
Stress Hypo-activation
Definition
Seasonal Depression, Chronic Fatigue, Fibromyalgia
Term
Pleochromocytoma
Definition
Tumor that secretes Epi and Norepi (chromaffin cells)
Panic, Anxiety, Palpitations
Term
KleinFelter's
Definition
XXY
Low Testosterone, High FSH and LH
Gynecomastia
Term
McCune-Albright Syndrome
Definition
Start releasing LH and FSH at an early age
Bone Deformities
Early Puberty
Term
Turner's Syndrome
Definition
Females with one X
Cognitive Defects, Ovary dysfunction, Heart Disease
Term
Granulomatous Disease
Definition
Increased Synthesis of active Vitamin D
Macrophages express 1-alpha-hydroxylase
Term
Hypercalcemia (parathyroid tumor)
Definition
Stones, Bones, Groans, and Psychic Moans
Kidney Stones, Bone pain, myopathies, CNS(fatigue, confusion)
Above 15 mg/dl can cause coma and cardiac arrest
Term
Primary Hyperparathyroidism
Definition
Tumor
Increased Ca+
Decreased PO4
Term
Secondary Hyperparathyroidism
Definition
Kidney Damage
Elevated PO4
Decreased Ca+
Increased PTH
Diabetes is main Cause
Term
Hypocalcemia
Definition
Low Ca+, High PO4
Decreased Cardiac contractility
Tetany (paresthesia of lips, fingers, toes)
Trousseau's Sign: carpal spasm w/ BP cuff
Chvostek's Sign: Facial Contraction tapping on facial nerve
Term
Psuedohypoparathyroidism
Albright's hereditary osteodystrophy
Definition
Lack of response to hormone
Hypocalcemia, hyperphosphatemia
Term
Vitamin D deficiency (Ricket's, Osteomalacia)
Definition
Enamel Hypoplasia, Osteoporosis
Loss of collagen and mineral in bone.
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